BCL9 - BCL9 transcription coactivator Gene

Also Known as LGS

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 607

About BCL9

Cytogenetic location: 1q21.2 Genomic coordinates (GRCh38): 1:147,541,501-147,626,216 (from NCBI)

This gene has 4 transcripts (splice variants), 221 orthologues, 1 paralogue and is associated with 72 phenotypes. Ubiquitous expression in endometrium (RPKM 9.5), ovary (RPKM 8.1) and 25 other tissues.

Summary

BCL9 is associated with B-cell acute lymphoblastic leukemia. It may be a target of translocation in B-cell malignancies with abnormalities of 1q21. Its function is unknown. The overexpression of BCL9 may be of pathogenic significance in B-cell malignancies. [provided by RefSeq, Jul 2008]

BCL9 Products (1)

mRNA Protein Name
NM_004326.4 NP_004317.2 B-cell CLL/lymphoma 9 protein

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
11955446 GOA
Biological Process GO Annotation Evidence References Source
NOT involved in regulation of transforming growth factor beta receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
19328798 GOA
Cellular Component GO Annotation Evidence References Source
part of beta-catenin-TCF complex IDA
IDA: Inferred from direct assay
28296634 GOA
part of beta-catenin-TCF complex IPI
IPI: Inferred from physical interaction
11955446 GOA
located in cis-Golgi network IDA
IDA: Inferred from direct assay
23386608 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

BCL9 Protein Structure

BCL9

BCL9: B-cell lymphoma 9 protein (350 - 389)

  • 0
  • 300
  • 600
  • 900
  • 1200
  • 1426 a.a.
Protein Preferred Names Protein Names

B-cell CLL/lymphoma 9 protein

  • B cell CLL/lymphoma 9

BCL9 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
BCL9 O00512 PYGO1 Homo sapiens Q9Y3Y4
X-Ray Diffraction
18498752
Intra
BCL9 O00512 PYGO1 Homo sapiens Q9Y3Y4
Pull Down
18498752
Intra
BCL9 O00512 CTNNB1 Homo sapiens P35222
Pull Down
11955446
Intra
BCL9 O00512 CTNNB1 Homo sapiens P35222
X-Ray Diffraction
17052462
Intra
BCL9 O00512 PYGO2 Homo sapiens Q9BRQ0
Anti Tag CoIP
17113272
Intra
BCL9 O00512 PYGO2 Homo sapiens Q9BRQ0
Anti Tag CoIP
21399610
Cross
BCL9 O00512 pygo Drosophila melanogaster Q9V9W8
Y2H
11955446
Cross
BCL9 O00512 arm Drosophila melanogaster P18824
Y2H
11955446
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Leukemia

  • Leukemias

  • Leukaemia, Unspecified, Without Mention Of Remission

  • Aleukemic Leukaemia

  • Chronic Leukaemia

  • Subacute Leukaemia

  • Leukaemia Disorder

  • Leukaemia Nos
Lymphoma

  • Lymphoid Cancer

  • Lymphomas

  • Lymphoid Cancers

  • Lymphoid Neoplasm

  • Lymphoma Nos

  • Nhl - [Non-Hodgkin Lymphoma]

  • Non-Hodgkin Lymphoma

  • Non-Hodgkin Lymphoma, Nos

  • Non-Hodgkin Malignant Lymphoma Nos
B-Cell Lymphoma

  • Lymphoma, B-Cell

  • B-Cell Lymphomas

  • B-Cell Lymphocytic Neoplasm

  • Lymphoma B-Cell

  • B-Cell Lymphoma Nos
Hepatocellular Carcinoma

  • Liver Cancer

  • Primary Liver Cancer

  • HCC

  • Hepatoma

  • Malignant Neoplasm Of Liver

  • Liver Neoplasms

  • Cancer, Hepatocellular

  • Liver Cell Carcinoma

  • Lcc

  • Hepatoblastoma, Somatic

  • Hepatic Cancer

  • Primary Malignant Neoplasm Of Liver

  • Rare Tumor Of Liver And Intrahepatic Biliary Tract

  • Hepatocellular Carcinoma, Somatic

  • Hepatocellular Carcinoma, Childhood Type, Somatic

  • Hepatocellular Cancer, Somatic

  • Ca Liver - Primary

  • Hepatic Neoplasm

  • Malignant Hepato-Biliary Neoplasm

  • Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary

  • Malignant Neoplasm Of Liver, Primary

  • Malignant Tumor Of Liver

  • Neoplasm Of Liver

  • Non-Resectable Primary Hepatic Malignant Neoplasm

  • Resectable Malignant Neoplasm Of Liver

  • Resectable Malignant Neoplasm Of The Liver

  • Primary Liver Carcinoma

  • Primary Malignant Liver Neoplasm

  • Primary Cancer Of Liver

  • Primary Tumor Of The Liver

  • Rare Tumor Of Liver And Ibt

  • Hepatocellular Cancer

  • Neoplasm Of The Liver

  • Carcinoma, Hepatocellular

  • Hepatomas

  • Liver Neoplasm

  • Liver Carcinoma

  • Liver And Intrahepatic Biliary Tract Carcinoma

  • Malignant Hepatobiliary Neoplasm

  • Adult Primary Hepatocellular Carcinoma

  • Hepatoblastoma

  • Carcinoma Of Liver

  • Malignant Liver Tumour

  • Malignant Hepatic Tumour
Retinitis Pigmentosa

  • RP

  • Rod-Cone Dystrophy

  • Autosomal Recessive Retinitis Pigmentosa

  • Non-Syndromic Retinitis Pigmentosa

  • Pericentral Pigmentary Retinopathy

  • Pigmentary Retinopathy

  • Tapetoretinal Degeneration

  • Rcd

  • Retinitis Pigmentosa Autosomal Recessive

  • ARRP

  • Retinitis Pigmentosa, Autosomal Recessive

  • Retinitis Pigmentosa 1
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (13)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-132300 ZW4864 Inhibitor 98.06% Unkown
HY-132300A ZW4864 free base Inhibitor 99.42% Unkown
HY-163768 Antitumor agent-172 Inhibitor 98.51% Unkown
HY-163767 Antitumor agent-171 Inhibitor 98.48% Unkown
HY-148918 E722-2648 Inhibitor / Unkown
HY-148918A E722-2648 TFA Inhibitor 96.33% Unkown
HY-161087 β-catenin/BCL9 PPI-IN-1 Inhibitor / Unkown
HY-RS01443 BCL9 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS01444 BCL9L Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21497 Bcl9l Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22110 Bcl9 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28015 Bcl9l Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28632 Bcl9 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta BCL9 VGNC VGNC:70041
Canis familiaris BCL9 VGNC VGNC:58090
Rattus norvegicus BCL9 RGD RGD:1306934
Bos taurus BCL9 VGNC VGNC:58092
Mus musculus BCL9 MGD MGI:1924828
Felis catus BCL9 VGNC VGNC:60089
Others BCL9 NCBI