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Cat. No.: HY-161087

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β-catenin/BCL9 PPI-IN-1

β-catenin/BCL9 PPI-IN-1 (compound B4) is a potent inhibitor of β catenin/B-Cell lymphoma 9 protein?protein interaction (β catenin/BCL9 PPI) with the IC₅₀ value of 2.25 μM.

For research use only. We do not sell to patients.

Formula: C₂₂H₁₆O₇
Molecular Weight:392.36

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

β-catenin/BCL9 PPI-IN-1 Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

β-catenin/BCL9 PPI-IN-1 (compound B4) is a potent inhibitor of β catenin/B-Cell lymphoma 9 protein?protein interaction (β catenin/BCL9 PPI) with the IC₅₀ value of 2.25 μM^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
CT26	IC₅₀	1.69 μM Compound: B4	Antiproliferative activity against mouse CT26 cells harboring active Wnt/beta-catenin signal assessed as inhibition of cell proliferation by CCK8 assay Antiproliferative activity against mouse CT26 cells harboring active Wnt/beta-catenin signal assessed as inhibition of cell proliferation by CCK8 assay	[PMID: 38097141]
HCT-116	IC₅₀	1.7 μM Compound: B4	Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell proliferation by CCK8 assay Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell proliferation by CCK8 assay	[PMID: 38097141]

Chemical Information

Molecular Weight 392.36
Formula C₂₂H₁₆O₇
SMILES

OC1=CC(O)=C(C(C(O)=C(C2=CC(O)=C(O)C=C2)O3)=O)C3=C1C4=CC=C(C)C=C4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Xinyan Peng, et al. Design, synthesis, and biological evaluation of novel 8-substituted quercetin derivatives targeting the β‑catenin/B-cell lymphoma 9 interaction. Bioorg Med Chem Lett. 2023 Dec 13:98:129591. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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