PYGO1 - pygopus family PHD finger 1 Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 26108

About PYGO1

Cytogenetic location: 15q21.3 Genomic coordinates (GRCh38): 15:55,538,884-55,588,971 (from NCBI)

This gene has 3 transcripts (splice variants), 148 orthologues and 1 paralogue. Broad expression in thyroid (RPKM 4.1), endometrium (RPKM 3.0) and 20 other tissues.

Summary

Enables methylated histone binding activity. Predicted to be involved in kidney development and spermatid nucleus differentiation. Predicted to act upstream of or within several processes, including hematopoietic progenitor cell differentiation; protein localization to nucleus; and spermatid development. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]

PYGO1 Products (3)

mRNA Protein Name
NM_001330326.2 NP_001317255.1 pygopus homolog 1 isoform 2
NM_001367806.1 NP_001354735.1 pygopus homolog 1 isoform 2
NM_015617.3 NP_056432.1 pygopus homolog 1 isoform 1

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables methylated histone binding IDA
IDA: Inferred from direct assay
18498752 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
18498752 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PYGO1 Protein Structure

PHD

PHD: PHD-finger (343 - 397)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 419 a.a.
Protein Preferred Names Protein Names

pygopus homolog 1

  • pygopus-like protein 1

PYGO1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
PYGO1 Q9Y3Y4 NEK7 Homo sapiens Q8TDX7
Validated Y2H
32814053
Intra
PYGO1 Q9Y3Y4 NEK7 Homo sapiens Q8TDX7
Y2H Array
32814053
Intra
PYGO1 Q9Y3Y4 NEK7 Homo sapiens Q8TDX7
Y2H Pooling
32814053
Intra
PYGO1 Q9Y3Y4 BCL9 Homo sapiens O00512
TAP
24981860
Intra
PYGO1 Q9Y3Y4 BCL9 Homo sapiens O00512
X-Ray Diffraction
18498752
Intra
PYGO1 Q9Y3Y4 BCL9 Homo sapiens O00512
GMS
18498752
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Eccrine Acrospiroma

  • Acrospiroma

  • Poroma

  • Eccrine Hidradenoma

  • Eccrine Hidradenoma Of Skin

  • Hidradenoma

  • Adenoma, Sweat Gland

  • Benign Neoplasm Of Sweat Gland

  • Eccrine Poroma
Eccrine Sweat Gland Neoplasm

  • Eccrine Skin Neoplasm

  • Eccrine Tumor

  • Eccrine Neoplasm

  • Malignant Eccrine Neoplasm
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS11491 PYGO1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus PYGO1 VGNC VGNC:33590
Canis familiaris PYGO1 VGNC VGNC:49878
Rattus norvegicus PYGO1 RGD RGD:1594620
Felis catus PYGO1 VGNC VGNC:64452
Mus musculus PYGO1 MGD MGI:1919385
Others PYGO1 NCBI