LEO1 - LEO1 homolog, Paf1/RNA polymerase II complex component Gene

Also Known as RDL

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 123169

About LEO1

Cytogenetic location: 15q21.2 Genomic coordinates (GRCh38): 15:51,938,025-51,971,778 (from NCBI)

This gene has 3 transcripts (splice variants) and 203 orthologues. Ubiquitous expression in colon (RPKM 10.8), urinary bladder (RPKM 9.3) and 25 other tissues.

Summary

LEO1, parafibromin (CDC73; MIM 607393), CTR9 (MIM 609366), and PAF1 (MIM 610506) form the PAF protein complex that associates with the RNA polymerase II subunit POLR2A (MIM 180660) and with a Histone Methyltransferase complex (Rozenblatt-Rosen et al., 2005 [PubMed 15632063]).[supplied by OMIM, Mar 2008]

LEO1 Products (4)

mRNA	Protein	Name
NM_001286430.2	NP_001273359.1	RNA polymerase-associated protein LEO1 isoform 2
NM_001323903.2	NP_001310832.1	RNA polymerase-associated protein LEO1 isoform 3
NM_001323904.2	NP_001310833.1	RNA polymerase-associated protein LEO1 isoform 4
NM_138792.4	NP_620147.1	RNA polymerase-associated protein LEO1 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	15923622	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in mRNA 3'-end processing	IMP IMP: Inferred from mutant phenotype	21329879	GOA
involved in negative regulation of myeloid cell differentiation	IDA IDA: Inferred from direct assay	20541477	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	16307923	GOA
involved in stem cell population maintenance	IDA IDA: Inferred from direct assay	19345177	GOA
involved in transcription elongation by RNA polymerase II	IDA IDA: Inferred from direct assay	20178742	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of Cdc73/Paf1 complex	IDA IDA: Inferred from direct assay	16307923	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LEO1 Protein Structure

Leo1

0
200
400
600
666 a.a.

Protein Preferred Names	Protein Names
RNA polymerase-associated protein LEO1	Leo1 Paf1/RNA polymerase II complex component

LEO1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	LEO1	Q8WVC0	GPRASP3	Homo sapiens	Q6PI77	Y2H Array	32296183
Intra	LEO1	Q8WVC0	GPRASP3	Homo sapiens	Q6PI77	Y2H Prey Pooling	32296183
Intra	LEO1	Q8WVC0	PAF1	Homo sapiens	Q8N7H5	Anti Tag CoIP	20178742
Intra	LEO1	Q8WVC0	PAF1	Homo sapiens	Q8N7H5	Anti Tag CoIP	26496610
Intra	LEO1	Q8WVC0	PAF1	Homo sapiens	Q8N7H5	Y2H Array	25416956
Intra	LEO1	Q8WVC0	PAF1	Homo sapiens	Q8N7H5	Anti Tag CoIP	16024656
Intra	LEO1	Q8WVC0	TCEA3	Homo sapiens	O75764	Y2H Prey Pooling	32296183
Intra	LEO1	Q8WVC0	TCEA3	Homo sapiens	O75764	Y2H Array	32296183
Intra	LEO1	Q8WVC0	CTNNB1	Homo sapiens	P35222	Anti Bait CoIP	16630820
Intra	LEO1	Q8WVC0	CDC73	Homo sapiens	Q6P1J9	Anti Tag CoIP	26496610
Intra	LEO1	Q8WVC0	CDC73	Homo sapiens	Q6P1J9	Anti Tag CoIP	16024656
Intra	LEO1	Q8WVC0	CDC73	Homo sapiens	Q6P1J9	Anti Tag CoIP	20178742

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Malignant Fibrous Histiocytoma Of Bone	Malignant Fibrous Histiocytoma Of The Bone
Chiasmal Syndrome	Chiasma Syndrome Disorder Of Optic Chiasm Optic Chiasm Disorder Chiasmal Optic Disorder Disease Of Optic Chiasm Chiasmal Lesion Intrachiasmal Lesion Prechiasmal Lesion
Hereditary Wilms' Tumor	Hereditary Wilms Tumor Hereditary Wilms Tumour Hereditary Wilms' Tumour Wt1
Branchiootorenal Syndrome 1	Melnick-Fraser Syndrome BOR1 Branchiootorenal Dysplasia Branchiootorenal Syndrome 1, With Or Without Cataracts Bor Syndrome 1 Branchiootorenal Dysplasia 1 Branchio-Oto-Renal Dysplasia 1 Branchio-Oto-Renal Syndrome Type 1 Branchiootorenal Syndrome, With/Without Cataract, Type 1 Branchio-Oto-Renal Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07592	LEO1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22216	Leo1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28738	Leo1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	LEO1	MGD	MGI:2685031
Rattus norvegicus	LEO1	RGD	RGD:1549772
Canis familiaris	LEO1	VGNC	VGNC:59117
Felis catus	LEO1	VGNC	VGNC:63214
Bos taurus	LEO1	VGNC	VGNC:30841
Others	LEO1	NCBI