TCEA3 - transcription elongation factor A3 Gene

Also Known as TFIIS; TFIIS.H

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 6920

About TCEA3

Cytogenetic location: 1p36.12 Genomic coordinates (GRCh38): 1:23,380,909-23,424,748 (from NCBI)

This gene has 6 transcripts (splice variants), 1 gene allele, 221 orthologues and 3 paralogues. Ubiquitous expression in colon (RPKM 19.3), ovary (RPKM 18.5) and 23 other tissues.

Summary

Predicted to enable DNA binding activity and zinc ion binding activity. Predicted to be involved in regulation of transcription, DNA-templated and transcription, DNA-templated. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]

TCEA3 Products (1)

mRNA	Protein	Name
NM_003196.3	NP_003187.1	transcription elongation factor A protein 3

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TCEA3 Protein Structure

Med26

TFIIS_M

TFIIS_C

0
100
200
300
348 a.a.

Protein Preferred Names	Protein Names
transcription elongation factor A protein 3	rhabdomyosarcoma antigen MU-RMS-40.22

TCEA3 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	TCEA3	O75764	LEO1	Homo sapiens	Q8WVC0	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Spastic Paraplegia 24, Autosomal Recessive	SPG24 Spastic Paraplegia 24 Hereditary Spastic Paraplegia 24 Autosomal Recessive Spastic Paraplegia Type 24 Autosomal Recessive Spastic Paraplegia 24
Cockayne Syndrome	Cockayne'S Syndrome Dwarfism-Retinal Atrophy-Deafness Syndrome Neill-Dingwall Syndrome Progeria-Like Syndrome Progeroid Nanism Cs
Endocervical Adenocarcinoma	Endocervical Carcinoma
Rhabdomyosarcoma
De Sanctis-Cacchione Syndrome	Xerodermic Idiocy Xeroderma Pigmentosum With Neurologic Manifestation DSC Xerodermic Idiocy Of De Sanctis And Cacchione
Uv-Sensitive Syndrome	Uvss Uv Sensitive Syndrome Ultraviolet Sensitive Syndrome
Cockayne Syndrome B	Cockayne Syndrome Type 2 Cockayne Syndrome, Type B Cockayne Syndrome Type Ii CSB Cockayne Syndrome 2 Cockayne Syndrome Type B Ckn2 Cockayne Syndrome, Type Ii
Xeroderma Pigmentosum, Variant Type	Xeroderma Pigmentosum XPV Xeroderma Pigmentosum Variant Type Xeroderma Pigmentosum With Normal Dna Repair Rates Photosensitivity With Defective Dna Synthesis Xp De Sanctis-Cacchione Syndrome Desanctis-Cacchione Syndrome Xeroderma Pigmentosa Xerodermic Idiocy Xeroderma Pigmentosum Variant Xp - [Xeroderma Pigmentosum] Atrophoderma Pigmentosum

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14293	TCEA3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22848	Tcea3 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS29362	Tcea3 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	TCEA3	VGNC	VGNC:78281
Mus musculus	TCEA3	MGD	MGI:1196908
Rattus norvegicus	TCEA3	RGD	RGD:1311369
Canis familiaris	TCEA3	VGNC	VGNC:47184
Bos taurus	TCEA3	VGNC	VGNC:35681
Felis catus	TCEA3	VGNC	VGNC:66016
Others	TCEA3	NCBI