CPSF4 - cleavage and polyadenylation specific factor 4 Gene

Homo sapiens

Also known as NAR; NEB1; NEB-1; CPSF30

Gene ID: 10898 | Gene type: protein coding

About CPSF4

Cytogenetic location: 7q22.1 Genomic coordinates (GRCh38): 7:99,438,943-99,457,373 (from NCBI)

This gene has 13 transcripts (splice variants), 208 orthologues and 2 paralogues. Ubiquitous expression in testis (RPKM 7.2), lymph node (RPKM 4.8) and 25 other tissues.

Summary

Inhibition of the nuclear export of poly(A)-containing mRNAs caused by the influenza A virus NS1 protein requires its effector domain. The NS1 effector domain functionally interacts with the cellular 30 kDa subunit of cleavage and polyadenylation specific factor 4, an essential component of the 3' end processing machinery of cellular pre-mRNAs. In influenza virus-infected cells, the NS1 protein is physically associated with cleavage and polyadenylation specific factor 4, 30kD subunit. Binding of the NS1 protein to the 30 kDa protein in vitro prevents CPSF binding to the RNA substrate and inhibits 3' end cleavage and polyadenylation of host pre-mRNAs. Thus the NS1 protein selectively inhibits the nuclear export of cellular, and not viral, mRNAs. Multiple alternatively spliced transcript variants that encode different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

CPSF4 Products(5)

mRNA	Protein	Name
NM_001081559.3	NP_001075028.1	cleavage and polyadenylation specificity factor subunit 4 isoform 2
NM_001318160.2	NP_001305089.1	cleavage and polyadenylation specificity factor subunit 4 isoform 3
NM_001318161.2	NP_001305090.1	cleavage and polyadenylation specificity factor subunit 4 isoform 4
NM_001318162.2	NP_001305091.1	cleavage and polyadenylation specificity factor subunit 4 isoform 5
NM_006693.4	NP_006684.1	cleavage and polyadenylation specificity factor subunit 4 isoform 1

CPSF4 Protein Structure

zf-CCCH

zf-CCHC

0
100
200
269 a.a.

Protein Preferred Names

Protein Names

cleavage and polyadenylation specificity factor subunit 4

CPSF 30 kDa subunit

Related Diseases

Diseases

Alias

Influenza

Flu	Influenza With Non-Respiratory Manifestation
Influenza With Other Manifestations	Influenza, Human
Influenza, Susceptibility To	Seasonal Influenza, Virus Identified

Median Neuropathy

Epidermolysis Bullosa Simplex 1a, Generalized Severe

Epidermolysis Bullosa Simplex, Dowling-Meara Type	Epidermolysis Bullosa Herpetiformis, Dowling-Meara Type
EBS1A	Ebsdm
Epidermolysis Bullosa Simplex Dowling-Meara Type	Epidermolysis Bullosa Simplex, Herpetiformis
Ebs-Dm	Epidermolysis Bullosa Simplex 1a, Dowling-Meara Type
Ebs-Gen Sev	Epidermolysis Bullosa Herpetiformis Dowling-Meara Type
Generalized Severe Epidermolysis Bullosa Simplex	Dowling-Meara Type Epidermolysis Bullosa Simplex
Autosomal Dominant Generalized Epidermolysis Bullosa Simplex, Severe Form	Autosomal Dominant Generalized Ebs, Severe Form
Epidermolysis Bullosa Simplex Herpetiformis	Dm-Ebs
Epidermolysis Bullosa Simplex, Generalized Severe	Epidermolysis Bullosa Herpetiformis, Dowling-Meara
Epidermolysis Bullosa Herpetiformis Dowling-Meara

Gestational Ovarian Choriocarcinoma

Corpus Luteum Cyst

Cystic Corpus Luteum	Luteal Cystic Ovary Disease
Lutein Cyst	Granulosa Lutein Cyst

Swine Influenza

Influenza Due To Influenza A Virus Subtype H1n1

Avian Influenza

Bird Flu	Influenza In Birds
Avian Flu

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03119	CPSF4 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	CPSF4	VGNC	VGNC:39576
Bos taurus	CPSF4	VGNC	VGNC:27673
Macaca mulatta	CPSF4	VGNC	VGNC:71474
Rattus norvegicus	CPSF4	RGD	RGD:620440
Mus musculus	CPSF4	MGD	MGI:1861602
Felis catus	CPSF4	VGNC	VGNC:61142

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