CPSF4 - cleavage and polyadenylation specific factor 4 Gene

Also Known as NAR; NEB1; NEB-1; CPSF30

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 10898

About CPSF4

Cytogenetic location: 7q22.1 Genomic coordinates (GRCh38): 7:99,438,943-99,457,373 (from NCBI)

This gene has 13 transcripts (splice variants), 208 orthologues and 2 paralogues. Ubiquitous expression in testis (RPKM 7.2), lymph node (RPKM 4.8) and 25 other tissues.

Summary

Inhibition of the nuclear export of poly(A)-containing mRNAs caused by the influenza A virus NS1 protein requires its effector domain. The NS1 effector domain functionally interacts with the cellular 30 kDa subunit of cleavage and polyadenylation specific factor 4, an essential component of the 3' end processing machinery of cellular pre-mRNAs. In influenza virus-infected cells, the NS1 protein is physically associated with cleavage and polyadenylation specific factor 4, 30kD subunit. Binding of the NS1 protein to the 30 kDa protein in vitro prevents CPSF binding to the RNA substrate and inhibits 3' end cleavage and polyadenylation of host pre-mRNAs. Thus the NS1 protein selectively inhibits the nuclear export of cellular, and not viral, mRNAs. Multiple alternatively spliced transcript variants that encode different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

CPSF4 Products (5)

mRNA Protein Name
NM_001081559.3 NP_001075028.1 cleavage and polyadenylation specificity factor subunit 4 isoform 2
NM_001318160.2 NP_001305089.1 cleavage and polyadenylation specificity factor subunit 4 isoform 3
NM_001318161.2 NP_001305090.1 cleavage and polyadenylation specificity factor subunit 4 isoform 4
NM_001318162.2 NP_001305091.1 cleavage and polyadenylation specificity factor subunit 4 isoform 5
NM_006693.4 NP_006684.1 cleavage and polyadenylation specificity factor subunit 4 isoform 1

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
16189514 GOA
enables sequence-specific double-stranded DNA binding IDA
IDA: Inferred from direct assay
28473536 GOA
Cellular Component GO Annotation Evidence References Source
part of mRNA cleavage and polyadenylation specificity factor complex IDA
IDA: Inferred from direct assay
21102410 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CPSF4 Protein Structure

zf-CCCH

zf-CCCH: Zinc finger C-x8-C-x5-C-x3-H type (and similar) (64 - 86)

zf-CCCH

zf-CCCH: Zinc finger C-x8-C-x5-C-x3-H type (and similar) (144 - 168)

zf-CCHC

zf-CCHC: Zinc knuckle (244 - 260)

  • 0
  • 100
  • 200
  • 269 a.a.
Protein Preferred Names Protein Names

cleavage and polyadenylation specificity factor subunit 4

  • CPSF 30 kDa subunit

CPSF4 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
CPSF4 O95639 FIP1L1 Homo sapiens Q6UN15
Anti Tag CoIP
33961781
Intra
CPSF4 O95639 FIP1L1 Homo sapiens Q6UN15
Y2H Pooling
16189514
Intra
CPSF4 O95639 MEOX2 Homo sapiens P50222
Validated Y2H
25416956
Intra
CPSF4 O95639 MEOX2 Homo sapiens P50222
Y2H Array
25416956
Intra
CPSF4 O95639 CDC73 Homo sapiens Q6P1J9
Anti Bait CoIP
19136632
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Influenza

  • Flu

  • Influenza With Non-Respiratory Manifestation

  • Influenza With Other Manifestations

  • Influenza, Human

  • Influenza, Susceptibility To

  • Seasonal Influenza, Virus Identified
Median Neuropathy
Epidermolysis Bullosa Simplex 1a, Generalized Severe

  • Epidermolysis Bullosa Simplex, Dowling-Meara Type

  • Epidermolysis Bullosa Herpetiformis, Dowling-Meara Type

  • EBS1A

  • Ebsdm

  • Epidermolysis Bullosa Simplex Dowling-Meara Type

  • Epidermolysis Bullosa Simplex, Herpetiformis

  • Ebs-Dm

  • Epidermolysis Bullosa Simplex 1a, Dowling-Meara Type

  • Ebs-Gen Sev

  • Epidermolysis Bullosa Herpetiformis Dowling-Meara Type

  • Generalized Severe Epidermolysis Bullosa Simplex

  • Dowling-Meara Type Epidermolysis Bullosa Simplex

  • Autosomal Dominant Generalized Epidermolysis Bullosa Simplex, Severe Form

  • Autosomal Dominant Generalized Ebs, Severe Form

  • Epidermolysis Bullosa Simplex Herpetiformis

  • Dm-Ebs

  • Epidermolysis Bullosa Simplex, Generalized Severe

  • Epidermolysis Bullosa Herpetiformis, Dowling-Meara

  • Epidermolysis Bullosa Herpetiformis Dowling-Meara
Gestational Ovarian Choriocarcinoma
Corpus Luteum Cyst

  • Cystic Corpus Luteum

  • Luteal Cystic Ovary Disease

  • Lutein Cyst

  • Granulosa Lutein Cyst
Swine Influenza

  • Influenza Due To Influenza A Virus Subtype H1n1
Avian Influenza

  • Bird Flu

  • Influenza In Birds

  • Avian Flu
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS03119 CPSF4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris CPSF4 VGNC VGNC:39576
Bos taurus CPSF4 VGNC VGNC:27673
Macaca mulatta CPSF4 VGNC VGNC:71474
Rattus norvegicus CPSF4 RGD RGD:620440
Mus musculus CPSF4 MGD MGI:1861602
Felis catus CPSF4 VGNC VGNC:61142