SKIC8 - SKI8 subunit of superkiller complex Gene
Also Known as SKI8; REC14; WDR61
Species: Homo sapiens
Gene Type: protein coding
Gene ID: 80349
Summary
WDR61 is a subunit of the human PAF and SKI complexes, which function in transcriptional regulation and are involved in events downstream of RNA synthesis, such as RNA surveillance (Zhu et al., 2005 [PubMed 16024656]).[supplied by OMIM, Mar 2008]
Ubiquitous expression in thyroid (RPKM 14.1), testis (RPKM 13.6) and 25 other tissues.
SKIC8 Products (3)
| mRNA | Protein | Name |
|---|---|---|
| NM_001303247.2 | NP_001290176.1 | superkiller complex protein 8 isoform a |
| NM_001303248.2 | NP_001290177.1 | superkiller complex protein 8 isoform b |
| NM_025234.3 | NP_079510.1 | superkiller complex protein 8 isoform a |
| Molecular Function GO Annotation | Evidence | References | Source |
|---|---|---|---|
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
16024656 | GOA |
| Biological Process GO Annotation | Evidence | References | Source |
|---|---|---|---|
| involved in negative regulation of myeloid cell differentiation |
IDA
IDA: Inferred from direct assay
|
20541477 | GOA |
| involved in nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay |
IDA
IDA: Inferred from direct assay
|
32006463 | GOA |
| involved in rescue of stalled ribosome |
IDA
IDA: Inferred from direct assay
|
32006463 | GOA |
| involved in transcription elongation by RNA polymerase II |
IDA
IDA: Inferred from direct assay
|
20178742 | GOA |
| Cellular Component GO Annotation | Evidence | References | Source |
|---|---|---|---|
| part of Cdc73/Paf1 complex |
IDA
IDA: Inferred from direct assay
|
20178742 | GOA |
| part of Ski complex |
IDA
IDA: Inferred from direct assay
|
16024656 | GOA |
| located in cytoplasm |
IDA
IDA: Inferred from direct assay
|
16024656 | GOA |
| located in euchromatin |
IDA
IDA: Inferred from direct assay
|
16024656 | GOA |
| located in nucleus |
IDA
IDA: Inferred from direct assay
|
16024656 | GOA |
EXP: Inferred from Experiment
IDA: Inferred from direct assay
IPI: Inferred from physical interaction
IMP: Inferred from mutant phenotype
IGI: Inferred from genetic interaction
IEP: Inferred from expression pattern
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SKIC8 Protein-protein interaction Information
|
Type
|
Protein Name | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | References |
|---|---|---|---|---|---|---|---|
|
Intra
|
SKIC8 | Q9GZS3 | CTR9 | Homo sapiens | Q6PD62 | 33961781 | |
|
Intra
|
SKIC8 | Q9GZS3 | CTR9 | Homo sapiens | Q6PD62 | 16024656 | |
|
Intra
|
SKIC8 | Q9GZS3 | CTR9 | Homo sapiens | Q6PD62 | 20178742 | |
|
Intra
|
SKIC8 | Q9GZS3 | JPH3 | Homo sapiens | Q8WXH2 | 32814053 | |
|
Intra
|
SKIC8 | Q9GZS3 | JPH3 | Homo sapiens | Q8WXH2 | 32814053 | |
|
Intra
|
SKIC8 | Q9GZS3 | JPH3 | Homo sapiens | Q8WXH2 | 32814053 | |
|
Intra
|
SKIC8 | Q9GZS3 | RAB7A | Homo sapiens | P51149 | 32814053 | |
|
Intra
|
SKIC8 | Q9GZS3 | RAB7A | Homo sapiens | P51149 | 32814053 | |
|
Intra
|
SKIC8 | Q9GZS3 | RAB7A | Homo sapiens | P51149 | 32814053 | |
|
Intra
|
SKIC8 | Q9GZS3 | PSEN1 | Homo sapiens | P49768-2 | 32814053 | |
|
Intra
|
SKIC8 | Q9GZS3 | PSEN1 | Homo sapiens | P49768-2 | 32814053 | |
|
Intra
|
SKIC8 | Q9GZS3 | PSEN1 | Homo sapiens | P49768-2 | 32814053 | |
|
Intra
|
SKIC8 | Q9GZS3 | SETX | Homo sapiens | Q7Z333 | 32814053 | |
|
Intra
|
SKIC8 | Q9GZS3 | SETX | Homo sapiens | Q7Z333 | 32814053 | |
|
Intra
|
SKIC8 | Q9GZS3 | SETX | Homo sapiens | Q7Z333 | 32814053 | |
|
Intra
|
SKIC8 | Q9GZS3 | APP | Homo sapiens | P05067-2 | 32814053 | |
|
Intra
|
SKIC8 | Q9GZS3 | APP | Homo sapiens | P05067-2 | 32814053 | |
|
Intra
|
SKIC8 | Q9GZS3 | APP | Homo sapiens | P05067-2 | 32814053 | |
|
Intra
|
SKIC8 | Q9GZS3 | GLE1 | Homo sapiens | Q53GS7 | 32814053 | |
|
Intra
|
SKIC8 | Q9GZS3 | GLE1 | Homo sapiens | Q53GS7 | 32814053 | |
|
Intra
|
SKIC8 | Q9GZS3 | GLE1 | Homo sapiens | Q53GS7 | 32814053 | |
|
Intra
|
SKIC8 | Q9GZS3 | DCTN1 | Homo sapiens | Q14203-5 | 32814053 | |
|
Intra
|
SKIC8 | Q9GZS3 | DCTN1 | Homo sapiens | Q14203-5 | 32814053 | |
|
Intra
|
SKIC8 | Q9GZS3 | DCTN1 | Homo sapiens | Q14203-5 | 32814053 | |
|
Intra
|
SKIC8 | Q9GZS3 | q9p1n4_human | Homo sapiens | Q9P1N4 | 32814053 | |
|
Intra
|
SKIC8 | Q9GZS3 | q9p1n4_human | Homo sapiens | Q9P1N4 | 32814053 | |
|
Intra
|
SKIC8 | Q9GZS3 | q9p1n4_human | Homo sapiens | Q9P1N4 | 32814053 | |
|
Intra
|
SKIC8 | Q9GZS3 | ALS2 | Homo sapiens | A0A0S2Z5Q7 | 32814053 | |
|
Intra
|
SKIC8 | Q9GZS3 | ALS2 | Homo sapiens | A0A0S2Z5Q7 | 32814053 | |
|
Intra
|
SKIC8 | Q9GZS3 | ALS2 | Homo sapiens | A0A0S2Z5Q7 | 32814053 | |
|
Intra
|
SKIC8 | Q9GZS3 | PANK2 | Homo sapiens | Q9BZ23-2 | 32814053 | |
|
Intra
|
SKIC8 | Q9GZS3 | PANK2 | Homo sapiens | Q9BZ23-2 | 32814053 | |
|
Intra
|
SKIC8 | Q9GZS3 | PANK2 | Homo sapiens | Q9BZ23-2 | 32814053 | |
|
Intra
|
SKIC8 | Q9GZS3 | TTBK2 | Homo sapiens | Q6IQ55-3 | 32814053 | |
|
Intra
|
SKIC8 | Q9GZS3 | TTBK2 | Homo sapiens | Q6IQ55-3 | 32814053 | |
|
Intra
|
SKIC8 | Q9GZS3 | TTBK2 | Homo sapiens | Q6IQ55-3 | 32814053 | |
|
Intra
|
SKIC8 | Q9GZS3 | LMNA | Homo sapiens | P02545-2 | 32814053 | |
|
Intra
|
SKIC8 | Q9GZS3 | LMNA | Homo sapiens | P02545-2 | 32814053 | |
|
Intra
|
SKIC8 | Q9GZS3 | LMNA | Homo sapiens | P02545-2 | 32814053 | |
|
Intra
|
SKIC8 | Q9GZS3 | RNF11 | Homo sapiens | Q9Y3C5 | 32814053 | |
|
Intra
|
SKIC8 | Q9GZS3 | RNF11 | Homo sapiens | Q9Y3C5 | 32814053 | |
|
Intra
|
SKIC8 | Q9GZS3 | RNF11 | Homo sapiens | Q9Y3C5 | 32814053 | |
|
Intra
|
SKIC8 | Q9GZS3 | SPRED1 | Homo sapiens | Q7Z699 | 32814053 | |
|
Intra
|
SKIC8 | Q9GZS3 | SPRED1 | Homo sapiens | Q7Z699 | 32814053 | |
|
Intra
|
SKIC8 | Q9GZS3 | SPRED1 | Homo sapiens | Q7Z699 | 32814053 | |
|
Intra
|
SKIC8 | Q9GZS3 | ATXN10 | Homo sapiens | Q9UBB4 | 32814053 | |
|
Intra
|
SKIC8 | Q9GZS3 | ATXN10 | Homo sapiens | Q9UBB4 | 32814053 | |
|
Intra
|
SKIC8 | Q9GZS3 | ATXN10 | Homo sapiens | Q9UBB4 | 32814053 | |
|
Intra
|
SKIC8 | Q9GZS3 | NDUFV2 | Homo sapiens | P19404 | 32814053 | |
|
Intra
|
SKIC8 | Q9GZS3 | NDUFV2 | Homo sapiens | P19404 | 32814053 | |
|
Intra
|
SKIC8 | Q9GZS3 | NDUFV2 | Homo sapiens | P19404 | 32814053 | |
|
Intra
|
SKIC8 | Q9GZS3 | SNCB | Homo sapiens | Q16143 | 32814053 | |
|
Intra
|
SKIC8 | Q9GZS3 | SNCB | Homo sapiens | Q16143 | 32814053 | |
|
Intra
|
SKIC8 | Q9GZS3 | SNCB | Homo sapiens | Q16143 | 32814053 | |
|
Intra
|
SKIC8 | Q9GZS3 | GFAP | Homo sapiens | P14136 | 32814053 | |
|
Intra
|
SKIC8 | Q9GZS3 | GFAP | Homo sapiens | P14136 | 32814053 | |
|
Intra
|
SKIC8 | Q9GZS3 | GFAP | Homo sapiens | P14136 | 32814053 | |
|
Intra
|
SKIC8 | Q9GZS3 | DBH | Homo sapiens | P09172 | 32814053 | |
|
Intra
|
SKIC8 | Q9GZS3 | DBH | Homo sapiens | P09172 | 32814053 | |
|
Intra
|
SKIC8 | Q9GZS3 | DBH | Homo sapiens | P09172 | 32814053 | |
|
Intra
|
SKIC8 | Q9GZS3 | PEX1 | Homo sapiens | O43933 | 32814053 | |
|
Intra
|
SKIC8 | Q9GZS3 | PEX1 | Homo sapiens | O43933 | 32814053 | |
|
Intra
|
SKIC8 | Q9GZS3 | PEX1 | Homo sapiens | O43933 | 32814053 |
Cross: Cross-species interaction
Intra: Intraspecies interaction