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  2. UBE2E1 - ubiquitin conjugating enzyme E2 E1 Gene

UBE2E1 - ubiquitin conjugating enzyme E2 E1 Gene

Homo sapiens

Also known as UBCH6

Gene ID: 7324 | Gene type: protein coding

About UBE2E1

Cytogenetic location: 3p24.2 Genomic coordinates (GRCh38): 3:23,805,955-23,891,640 (from NCBI)

This gene has 11 transcripts (splice variants), 148 orthologues and 12 paralogues. Ubiquitous expression in lymph node (RPKM 26.5), brain (RPKM 25.3) and 25 other tissues.

Summary

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating Enzyme family. Three alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jan 2011]

UBE2E1 Products(3)

mRNA Protein Name
NM_001202476.2 NP_001189405.1 ubiquitin-conjugating enzyme E2 E1 isoform 3
NM_003341.5 NP_003332.1 ubiquitin-conjugating enzyme E2 E1 isoform 1
NM_182666.3 NP_872607.1 ubiquitin-conjugating enzyme E2 E1 isoform 2

UBE2E1 Protein Structure

UQ_con

UQ_con: Ubiquitin-conjugating enzyme (51 - 187)

  • 0
  • 100
  • 193 a.a.
Protein Preferred Names Protein Names

ubiquitin-conjugating enzyme E2 E1

(E3-independent) E2 ubiquitin-conjugating enzyme E1

Recombinant UBE2E1 Proteins

Cat. No. Product Name Accession Purity
HY-P79450 UbcH6/UBE2E1 Protein, Human (His) P51965 ≥95%

Related Diseases

Diseases Alias
Limb-Girdle Muscular Dystrophy

Lgmd

Limb Girdle Muscular Dystrophy

Muscular Dystrophies, Limb-Girdle

Erb'S Muscular Dystrophy

Leyden-Mbius Muscular Dystrophy

Limb-Girdle Syndrome

Myopathic Limb-Girdle Syndrome

Limb Girdle

Muscular Dystrophy Limb-Girdle

Dystrophy, Muscular, Limb-Girdle

Lgmd - [Limb-Girdle Muscular Dystrophy]

Limb Girdle Muscle Dystrophy

Limb-Girdle Myopathy

Immunodeficiency 33

IMD33

X-Linked Mendelian Susceptibility To Mycobacterial Diseases Due To Ikbkg Deficiency

X-Linked Mendelian Susceptibility To Mycobacterial Diseases Due To Nemo Deficiency

X-Linked Msmd Due To Ikbkg Deficiency

X-Linked Msmd Due To Nemo Deficiency

Invasive Pneumococcal Disease, Recurrent Isolated, 2

Invasive Pneumococcal Disease, Recurrent Isolated, 2, Formerly

Ipd2, Formerly

Nf-Kappa B Essential Modulator Deficiency

Familial X-Linked 1 Atypical Mycobacteriosis

Nemo Deficiency Syndrome

Amcbx1

Familial, X-Linked, Atypical Mycobacteriosis 1

Ipd2

Recurrent Isolated Invasive Pneumococcal Disease 2

X-Linked Disseminated Atypical Mycobacterial Infection Type 1

X-Linked Immunodeficiency 33, Mycobacteriosis

X-Linked Susceptibility To Mycobacterial Disease Type 1

Invasive Pneumococcal Disease, Recurrent Isolated, Type 2

Atypical Mycobacteriosis, Familial, X-Linked 1

Spinocerebellar Ataxia 1

Spinocerebellar Ataxia Type 1

SCA1

Olivopontocerebellar Atrophy I

Opca1

Opca4

Menzel Type Opca

Schut-Haymaker Type Opca

Spinocerebellar Atrophy I

Opca I

Olivopontocerebellar Atrophy Iv

Opca Iv

Cerebelloparenchymal Disorder I

Cpd1

Olivopontocerebellar Atrophy 1

Cerebelloparenchymal Disorder 1

Olivopontocerebellar Atrophy 4

Spinocerebellar Atrophy 1

Type 1 Spinocerebellar Ataxia

Spinocerebellar Ataxia-1

Ataxia, Spinocerebellar, Type 1

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Canis familiaris UBE2E1 VGNC VGNC:52908
Rattus norvegicus UBE2E1 RGD RGD:2324438
Bos taurus UBE2E1 VGNC VGNC:107009
Mus musculus UBE2E1 MGD MGI:107411
Macaca mulatta UBE2E1 VGNC VGNC:78694
Felis catus UBE2E1 VGNC VGNC:102860
Others UBE2E1 NCBI