ZNRF1 - zinc and ring finger 1 Gene

Also Known as NIN283

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 84937

About ZNRF1

Cytogenetic location: 16q23.1 Genomic coordinates (GRCh38): 16:74,999,024-75,110,994 (from NCBI)

This gene has 11 transcripts (splice variants), 203 orthologues and 2 paralogues. Ubiquitous expression in testis (RPKM 4.3), thyroid (RPKM 4.3) and 25 other tissues.

Summary

This gene encodes an E3 ubiquitin-protein Ligase that plays a role in neural-cell differentiation. Overexpression of this gene causes neurite-like elongation. The encoded protein contains both a zinc finger and a RING finger motif and is localized in the endosome/lysosome compartment, indicating that it may be involved in ubiquitin-mediated protein modification, and in synaptic vessicle membranes in neurons. [provided by RefSeq, Feb 2012]

ZNRF1 Products (1)

mRNA	Protein	Name
NM_032268.5	NP_115644.1	E3 ubiquitin-protein ligase ZNRF1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	19549727	GOA
enables ubiquitin protein ligase activity	IDA IDA: Inferred from direct assay	22797923	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in positive regulation of autophagosome-lysosome fusion	IGI IGI: Inferred from genetic interaction	38360932	GOA
involved in positive regulation of toll-like receptor 4 signaling pathway	IDA IDA: Inferred from direct assay	28593998	GOA

Cellular Component GO Annotation	Evidence	References	Source
is active in cytoplasm	IDA IDA: Inferred from direct assay	22797923	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	38360932	GOA
located in cytosol	IDA IDA: Inferred from direct assay	22797923	GOA
located in membrane	IDA IDA: Inferred from direct assay	22797923	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ZNRF1 Protein Structure

zf-RING_2

0
100
200
227 a.a.

Protein Preferred Names	Protein Names
E3 ubiquitin-protein ligase ZNRF1	RING-type E3 ubiquitin transferase ZNRF1

ZNRF1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	ZNRF1	Q8ND25	UBE2V1	Homo sapiens	Q13404	Y2H Array	19549727
Intra	ZNRF1	Q8ND25	UBE2N	Homo sapiens	P61088	Y2H Array	19549727
Intra	ZNRF1	Q8ND25	UBE2N	Homo sapiens	P61088	Anti Tag CoIP	33961781
Intra	ZNRF1	Q8ND25	UBE2N	Homo sapiens	P61088	Y2H	19549727
Intra	ZNRF1	Q8ND25	UBE2D2	Homo sapiens	P62837	Y2H Array	19690564
Intra	ZNRF1	Q8ND25	UBE2D3	Homo sapiens	P61077	Y2H Array	19690564
Intra	ZNRF1	Q8ND25	UBE2E1	Homo sapiens	P51965	Y2H Array	19549727
Intra	ZNRF1	Q8ND25	UBE2D1	Homo sapiens	P51668	Enzymatic Study	19549727
Intra	ZNRF1	Q8ND25	UBE2D1	Homo sapiens	P51668	Y2H Array	19549727
Intra	ZNRF1	Q8ND25	UBE2D1	Homo sapiens	P51668	Y2H	19549727
Intra	ZNRF1	Q8ND25	UBE2D4	Homo sapiens	Q9Y2X8	Y2H Array	19549727
Intra	ZNRF1	Q8ND25	UBE2D4	Homo sapiens	Q9Y2X8	Y2H	19549727
Intra	ZNRF1	Q8ND25	UBE2D4	Homo sapiens	Q9Y2X8	Validated Y2H	32296183
Intra	ZNRF1	Q8ND25	UBE2D4	Homo sapiens	Q9Y2X8	Y2H Array	19690564

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Intermittent Explosive Disorder	Explosive Personality Disorder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS16183	ZNRF1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	ZNRF1	VGNC	VGNC:79140
Felis catus	ZNRF1	VGNC	VGNC:67371
Rattus norvegicus	ZNRF1	RGD	RGD:1592195
Canis familiaris	ZNRF1	VGNC	VGNC:48839
Bos taurus	ZNRF1	VGNC	VGNC:37363
Mus musculus	ZNRF1	MGD	MGI:2177308
Others	ZNRF1	NCBI