UEV-1
UEV-1 is a ubiquitin-conjugating enzyme variant, the human UEV1A/MMS2 protein, in which the catalytic cysteine of a canonical E2 has been lost during evolution. Instead of transferring ubiquitin itself, UEV-1 heterodimerizes tightly with UBE2N (UBC13), and the duo synthesizes K63-linked polyubiquitin chains that serve as non-proteolytic signaling scaffolds. These chains activate NF-κB through the TAK1 complex and mediate error-free postreplication DNA repair. UEV1A is expressed in proliferating cells and has been linked to cell cycle progression and tumorigenesis when overexpressed. Recombinant UEV-1 is routinely combined with UBE2N to generate K63 chains for signaling and enzyme studies.
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UEV-1 Recombinant Proteins (1)
- Species:
- Source:
Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
