POM121 - POM121 transmembrane nucleoporin Gene

Also Known as P145; POM121A

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 9883

About POM121

Cytogenetic location: 7q11.23 Genomic coordinates (GRCh38): 7:72,879,357-72,951,459 (from NCBI)

This gene has 3 transcripts (splice variants), 210 orthologues and 6 paralogues. Ubiquitous expression in bone marrow (RPKM 16.6), spleen (RPKM 15.4) and 25 other tissues.

Summary

This gene encodes a transmembrane protein that localizes to the inner nuclear membrane and forms a core component of the nuclear pore complex, which mediates transport to and from the nucleus. The encoded protein may anchor this complex to the nuclear envelope. There are multiple related genes and pseudogenes for this gene on chromosomes 5, 7, 15, and 22. Alternatively spliced transcript variants encoding different isoforms have been observed. [provided by RefSeq, Jul 2013]

POM121 Products (23)

mRNA	Protein	Name
NM_001257190.3	NP_001244119.1	nuclear envelope pore membrane protein POM 121 isoform 1
NM_001367610.1	NP_001354539.1	nuclear envelope pore membrane protein POM 121 isoform 3
NM_001387685.1	NP_001374614.1	nuclear envelope pore membrane protein POM 121 isoform 2
NM_001387686.1	NP_001374615.1	nuclear envelope pore membrane protein POM 121 isoform 2
NM_001387687.1	NP_001374616.1	nuclear envelope pore membrane protein POM 121 isoform 2
NM_001387688.1	NP_001374617.1	nuclear envelope pore membrane protein POM 121 isoform 2
NM_001387689.1	NP_001374618.1	nuclear envelope pore membrane protein POM 121 isoform 2
NM_001387691.1	NP_001374620.1	nuclear envelope pore membrane protein POM 121 isoform 4
NM_001387692.1	NP_001374621.1	nuclear envelope pore membrane protein POM 121 isoform 5
NM_001387693.1	NP_001374622.1	nuclear envelope pore membrane protein POM 121 isoform 6
NM_001387694.1	NP_001374623.1	nuclear envelope pore membrane protein POM 121 isoform 7
NM_001387695.1	NP_001374624.1	nuclear envelope pore membrane protein POM 121 isoform 2
NM_001387696.1	NP_001374625.1	nuclear envelope pore membrane protein POM 121 isoform 2
NM_001387697.1	NP_001374626.1	nuclear envelope pore membrane protein POM 121 isoform 2
NM_001387698.1	NP_001374627.1	nuclear envelope pore membrane protein POM 121 isoform 2
NM_001387699.1	NP_001374628.1	nuclear envelope pore membrane protein POM 121 isoform 2
NM_001387700.1	NP_001374629.1	nuclear envelope pore membrane protein POM 121 isoform 2
NM_001387701.1	NP_001374630.1	nuclear envelope pore membrane protein POM 121 isoform 3
NM_001387702.1	NP_001374631.1	nuclear envelope pore membrane protein POM 121 isoform 3
NM_001387703.1	NP_001374632.1	nuclear envelope pore membrane protein POM 121 isoform 3
NM_001387704.1	NP_001374633.1	nuclear envelope pore membrane protein POM 121 isoform 3
NM_001387705.1	NP_001374634.1	nuclear envelope pore membrane protein POM 121 isoform 8
NM_172020.5	NP_742017.1	nuclear envelope pore membrane protein POM 121 isoform 2

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in nuclear envelope	IDA IDA: Inferred from direct assay	24315095	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

POM121 Protein Structure

POM121

0
200
400
600
800
1000
1249 a.a.

Protein Preferred Names	Protein Names
nuclear envelope pore membrane protein POM 121	POM121 membrane glycoprotein

POM121 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	POM121	Q96HA1	PAXIP1	Homo sapiens	Q6ZW49-2	Y2H Prey Pooling	25416956
Intra	POM121	Q96HA1	AGR2	Homo sapiens	O95994	Y2H Pooling	16189514
Intra	POM121	Q96HA1	RBPMS	Homo sapiens	Q93062	Y2H Pooling	16189514
Intra	POM121	Q96HA1	RBPMS	Homo sapiens	Q93062	Validated Y2H	25416956
Intra	POM121	Q96HA1	FXR2	Homo sapiens	P51116	Validated Y2H	25416956
Intra	POM121	Q96HA1	TEX11	Homo sapiens	Q8IYF3	Y2H Pooling	16189514
Intra	POM121	Q96HA1	TEX11	Homo sapiens	Q8IYF3	Y2H Array	25416956
Intra	POM121	Q96HA1	HOMER3	Homo sapiens	Q9NSC5	Validated Y2H	25416956
Intra	POM121	Q96HA1	HOMER3	Homo sapiens	Q9NSC5	Y2H Prey Pooling	25416956
Intra	POM121	Q96HA1	HOMER3	Homo sapiens	Q9NSC5	Y2H Array	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Acute Dacryocystitis	Dacryocystitis - Acute
Trachea Adenoid Cystic Carcinoma	Tracheal Adenoid Cystic Carcinoma Adenoid Cystic Carcinoma Of Trachea

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10864	POM121 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	POM121	MGD	MGI:2137624
Rattus norvegicus	POM121	RGD	RGD:620680