HOMER3 - homer scaffold protein 3 Gene
Also Known as VESL3; HOMER-3
Species: Homo sapiens
About HOMER3
This gene has 12 transcripts (splice variants), 206 orthologues and 2 paralogues. Broad expression in spleen (RPKM 29.6), kidney (RPKM 6.7) and 19 other tissues.
Summary
This gene encodes a member of the HOMER family of postsynaptic density scaffolding proteins that share a similar domain structure consisting of an N-terminal Enabled/vasodilator-stimulated phosphoprotein homology 1 domain which mediates protein-protein interactions, and a carboxy-terminal coiled-coil domain and two leucine zipper motifs that are involved in self-oligomerization. The encoded protein binds numerous Other proteins including group I Metabotropic Glutamate Receptors, inositol 1,4,5-trisphosphate receptors and amyloid precursor proteins and has been implicated in diverse biological functions such as Neuronal Signaling, T-cell activation and trafficking of amyloid beta peptides. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Mar 2009]
HOMER3 Products (4)
| mRNA | Protein | Name |
|---|---|---|
| NM_001145721.1 | NP_001139193.1 | homer protein homolog 3 isoform 2 |
| NM_001145722.2 | NP_001139194.1 | homer protein homolog 3 isoform 1 |
| NM_001145724.1 | NP_001139196.1 | homer protein homolog 3 isoform 3 |
| NM_004838.4 | NP_004829.3 | homer protein homolog 3 isoform 1 |
| Molecular Function GO Annotation | Evidence | References | Source |
|---|---|---|---|
| enables identical protein binding |
IPI
IPI: Inferred from physical interaction
|
25416956 | GOA |
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
16189514 | GOA |
| Biological Process GO Annotation | Evidence | References | Source |
|---|---|---|---|
| involved in negative regulation of calcineurin-NFAT signaling cascade |
IMP
IMP: Inferred from mutant phenotype
|
18218901 | GOA |
| involved in negative regulation of interleukin-2 production |
IMP
IMP: Inferred from mutant phenotype
|
18218901 | GOA |
HOMER3 Protein Structure
WH1: WH1 domain (6 - 109)
- 0
- 100
- 200
- 300
- 361 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
homer protein homolog 3 |
|
HOMER3 Protein-protein interaction Information
|
Type
|
Protein Name | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | References |
|---|---|---|---|---|---|---|---|
|
Intra
|
HOMER3 | Q9NSC5 | RUNX1T1 | Homo sapiens | Q06455-4 | 25416956 | |
|
Intra
|
HOMER3 | Q9NSC5 | KRTAP19-7 | Homo sapiens | Q3SYF9 | 32296183 | |
|
Intra
|
HOMER3 | Q9NSC5 | KRTAP19-7 | Homo sapiens | Q3SYF9 | 32296183 | |
|
Intra
|
HOMER3 | Q9NSC5 | SLAIN1 | Homo sapiens | Q8ND83 | 32296183 | |
|
Intra
|
HOMER3 | Q9NSC5 | SLAIN1 | Homo sapiens | Q8ND83 | 32296183 | |
|
Intra
|
HOMER3 | Q9NSC5 | FRYL | Homo sapiens | O94915 | 16189514 | |
|
Intra
|
HOMER3 | Q9NSC5 | FRYL | Homo sapiens | O94915 | 33961781 | |
|
Intra
|
HOMER3 | Q9NSC5 | ABI2 | Homo sapiens | Q9NYB9-2 | 32296183 | |
|
Intra
|
HOMER3 | Q9NSC5 | ABI2 | Homo sapiens | Q9NYB9-2 | 32296183 | |
|
Intra
|
HOMER3 | Q9NSC5 | ABI2 | Homo sapiens | Q9NYB9-2 | 32296183 | |
|
Intra
|
HOMER3 | Q9NSC5 | ARL13B | Homo sapiens | Q3SXY8 | 32296183 | |
|
Intra
|
HOMER3 | Q9NSC5 | ARL13B | Homo sapiens | Q3SXY8 | 32296183 | |
|
Intra
|
HOMER3 | Q9NSC5 | MSS51 | Homo sapiens | Q4VC12 | 32296183 | |
|
Intra
|
HOMER3 | Q9NSC5 | MSS51 | Homo sapiens | Q4VC12 | 32296183 | |
|
Intra
|
HOMER3 | Q9NSC5 | FAT1 | Homo sapiens | Q14517 | 16979624 | |
|
Intra
|
HOMER3 | Q9NSC5 | FAT1 | Homo sapiens | Q14517 | 16979624 | |
|
Intra
|
HOMER3 | Q9NSC5 | FAT1 | Homo sapiens | Q14517 | 16979624 | |
|
Intra
|
HOMER3 | Q9NSC5 | ABI1 | Homo sapiens | Q8IZP0-5 | 32296183 | |
|
Intra
|
HOMER3 | Q9NSC5 | ABI1 | Homo sapiens | Q8IZP0-5 | 32296183 | |
|
Intra
|
HOMER3 | Q9NSC5 | PSORS1C2 | Homo sapiens | Q9UIG4 | 32296183 | |
|
Intra
|
HOMER3 | Q9NSC5 | FRYL | Homo sapiens | O94915-2 | 32296183 | |
|
Intra
|
HOMER3 | Q9NSC5 | FRYL | Homo sapiens | O94915-2 | 32296183 | |
|
Intra
|
HOMER3 | Q9NSC5 | LHX2 | Homo sapiens | P50458 | 32296183 | |
|
Intra
|
HOMER3 | Q9NSC5 | LHX2 | Homo sapiens | P50458 | 32296183 | |
|
Intra
|
HOMER3 | Q9NSC5 | PALLD | Homo sapiens | Q8WX93-2 | 32296183 | |
|
Intra
|
HOMER3 | Q9NSC5 | PALLD | Homo sapiens | Q8WX93-2 | 32296183 | |
|
Intra
|
HOMER3 | Q9NSC5 | TOX2 | Homo sapiens | Q96NM4-3 | 32296183 | |
|
Intra
|
HOMER3 | Q9NSC5 | TOX2 | Homo sapiens | Q96NM4-3 | 32296183 | |
|
Intra
|
HOMER3 | Q9NSC5 | PAX7 | Homo sapiens | P23759-2 | 32296183 | |
|
Intra
|
HOMER3 | Q9NSC5 | PAX7 | Homo sapiens | P23759-2 | 32296183 | |
|
Intra
|
HOMER3 | Q9NSC5 | ZNF19 | Homo sapiens | P17023 | 32296183 | |
|
Intra
|
HOMER3 | Q9NSC5 | ZNF19 | Homo sapiens | P17023 | 32296183 | |
|
Intra
|
HOMER3 | Q9NSC5 | MOS | Homo sapiens | P00540 | 25416956 | |
|
Intra
|
HOMER3 | Q9NSC5 | MOS | Homo sapiens | P00540 | 32296183 | |
|
Intra
|
HOMER3 | Q9NSC5 | LSM14B | Homo sapiens | Q9BX40-2 | 32296183 | |
|
Intra
|
HOMER3 | Q9NSC5 | LSM14B | Homo sapiens | Q9BX40-2 | 32296183 | |
|
Cross
|
HOMER3 | Q9NSC5 | yscB | Yersinia pestis | Q56973 | 21911467 | |
|
Cross
|
HOMER3 | Q9NSC5 | a0a3n4b5w9_yerpe | Yersinia pestis | A0A3N4B5W9 | 21911467 | |
|
Intra
|
HOMER3 | Q9NSC5 | MIA3 | Homo sapiens | Q5JRA6 | 32296183 | |
|
Intra
|
HOMER3 | Q9NSC5 | MIA3 | Homo sapiens | Q5JRA6 | 32296183 | |
|
Intra
|
HOMER3 | Q9NSC5 | SARG | Homo sapiens | Q9BW04 | 32296183 | |
|
Intra
|
HOMER3 | Q9NSC5 | SARG | Homo sapiens | Q9BW04 | 32296183 | |
|
Intra
|
HOMER3 | Q9NSC5 | PPP1R18 | Homo sapiens | Q6NYC8 | 25416956 | |
|
Intra
|
HOMER3 | Q9NSC5 | PPP1R18 | Homo sapiens | Q6NYC8 | 25416956 | |
|
Intra
|
HOMER3 | Q9NSC5 | ZBTB4 | Homo sapiens | Q9P1Z0 | 32296183 | |
|
Intra
|
HOMER3 | Q9NSC5 | RBM22 | Homo sapiens | Q9NW64 | 32296183 | |
|
Intra
|
HOMER3 | Q9NSC5 | MEOX1 | Homo sapiens | P50221 | 32296183 | |
|
Intra
|
HOMER3 | Q9NSC5 | MEOX1 | Homo sapiens | P50221 | 32296183 | |
|
Intra
|
HOMER3 | Q9NSC5 | NEBL | Homo sapiens | O76041 | 25416956 | |
|
Intra
|
HOMER3 | Q9NSC5 | APP | Homo sapiens | P05067-8 | 18387811 | |
|
Intra
|
HOMER3 | Q9NSC5 | WIPF1 | Homo sapiens | O43516 | 25416956 | |
|
Intra
|
HOMER3 | Q9NSC5 | WIPF1 | Homo sapiens | O43516 | 25416956 | |
|
Intra
|
HOMER3 | Q9NSC5 | DYNLL1 | Homo sapiens | P63167 | 32296183 | |
|
Intra
|
HOMER3 | Q9NSC5 | DYNLL1 | Homo sapiens | P63167 | 32296183 | |
|
Intra
|
HOMER3 | Q9NSC5 | EIF3D | Homo sapiens | O15371 | 25416956 | |
|
Intra
|
HOMER3 | Q9NSC5 | EIF3D | Homo sapiens | O15371 | 25416956 | |
|
Intra
|
HOMER3 | Q9NSC5 | SNRPF | Homo sapiens | P62306 | 25416956 | |
|
Intra
|
HOMER3 | Q9NSC5 | SNRPF | Homo sapiens | P62306 | 25416956 | |
|
Intra
|
HOMER3 | Q9NSC5 | SNRPF | Homo sapiens | P62306 | 32296183 | |
|
Intra
|
HOMER3 | Q9NSC5 | SNRPF | Homo sapiens | P62306 | 25416956 | |
|
Intra
|
HOMER3 | Q9NSC5 | SNRPF | Homo sapiens | P62306 | 32296183 | |
|
Intra
|
HOMER3 | Q9NSC5 | PSMA1 | Homo sapiens | P25786 | 32296183 | |
|
Intra
|
HOMER3 | Q9NSC5 | PSMA1 | Homo sapiens | P25786 | 32296183 | |
|
Intra
|
HOMER3 | Q9NSC5 | PSMA1 | Homo sapiens | P25786 | 25416956 | |
|
Intra
|
HOMER3 | Q9NSC5 | SAXO1 | Homo sapiens | Q8IYX7 | 32296183 | |
|
Intra
|
HOMER3 | Q9NSC5 | PKN1 | Homo sapiens | Q16512 | 25416956 | |
|
Intra
|
HOMER3 | Q9NSC5 | PKN1 | Homo sapiens | Q16512 | 21516116 | |
|
Intra
|
HOMER3 | Q9NSC5 | PKN1 | Homo sapiens | Q16512 | 25416956 | |
|
Intra
|
HOMER3 | Q9NSC5 | ZNF655 | Homo sapiens | Q8N720 | 32296183 | |
|
Intra
|
HOMER3 | Q9NSC5 | ZNF655 | Homo sapiens | Q8N720 | 32296183 | |
|
Intra
|
HOMER3 | Q9NSC5 | INCA1 | Homo sapiens | Q0VD86 | 32296183 | |
|
Intra
|
HOMER3 | Q9NSC5 | INCA1 | Homo sapiens | Q0VD86 | 32296183 | |
|
Intra
|
HOMER3 | Q9NSC5 | C4orf17 | Homo sapiens | Q53FE4 | 32296183 | |
|
Intra
|
HOMER3 | Q9NSC5 | WBP2 | Homo sapiens | Q969T9 | 32296183 | |
|
Intra
|
HOMER3 | Q9NSC5 | WBP2 | Homo sapiens | Q969T9 | 32296183 | |
|
Intra
|
HOMER3 | Q9NSC5 | LNX1 | Homo sapiens | Q8TBB1 | 32296183 | |
|
Intra
|
HOMER3 | Q9NSC5 | LNX1 | Homo sapiens | Q8TBB1 | 32296183 | |
|
Intra
|
HOMER3 | Q9NSC5 | FBXO28 | Homo sapiens | Q9NVF7 | 32296183 | |
|
Intra
|
HOMER3 | Q9NSC5 | FBXO28 | Homo sapiens | Q9NVF7 | 32296183 | |
|
Intra
|
HOMER3 | Q9NSC5 | FBXO28 | Homo sapiens | Q9NVF7 | 32296183 | |
|
Intra
|
HOMER3 | Q9NSC5 | POLI | Homo sapiens | Q9UNA4 | 32296183 | |
|
Intra
|
HOMER3 | Q9NSC5 | ABI3 | Homo sapiens | Q9P2A4 | 19060904 | |
|
Intra
|
HOMER3 | Q9NSC5 | ABI3 | Homo sapiens | Q9P2A4 | 32296183 | |
|
Intra
|
HOMER3 | Q9NSC5 | ABI3 | Homo sapiens | Q9P2A4 | 32296183 | |
|
Intra
|
HOMER3 | Q9NSC5 | ABI3 | Homo sapiens | Q9P2A4 | 19060904 | |
|
Intra
|
HOMER3 | Q9NSC5 | DYNLL2 | Homo sapiens | Q96FJ2 | 32296183 | |
|
Intra
|
HOMER3 | Q9NSC5 | DYNLL2 | Homo sapiens | Q96FJ2 | 16189514 | |
|
Intra
|
HOMER3 | Q9NSC5 | DYNLL2 | Homo sapiens | Q96FJ2 | 32296183 | |
|
Intra
|
HOMER3 | Q9NSC5 | ABI2 | Homo sapiens | Q9NYB9 | 25416956 | |
|
Intra
|
HOMER3 | Q9NSC5 | ABI2 | Homo sapiens | Q9NYB9 | 25416956 | |
|
Intra
|
HOMER3 | Q9NSC5 | ABI2 | Homo sapiens | Q9NYB9 | 29892012 | |
|
Intra
|
HOMER3 | Q9NSC5 | ABI2 | Homo sapiens | Q9NYB9 | 33961781 | |
|
Intra
|
HOMER3 | Q9NSC5 | HOMER1 | Homo sapiens | Q86YM7 | 32296183 | |
|
Intra
|
HOMER3 | Q9NSC5 | HOMER1 | Homo sapiens | Q86YM7 | 32296183 | |
|
Intra
|
HOMER3 | Q9NSC5 | HOMER1 | Homo sapiens | Q86YM7 | 32296183 | |
|
Intra
|
HOMER3 | Q9NSC5 | HOMER1 | Homo sapiens | Q86YM7 | 33961781 | |
|
Intra
|
HOMER3 | Q9NSC5 | PAX6 | Homo sapiens | P26367 | 32296183 | |
|
Intra
|
HOMER3 | Q9NSC5 | PAX6 | Homo sapiens | P26367 | 16098226 | |
|
Intra
|
HOMER3 | Q9NSC5 | PAX6 | Homo sapiens | P26367 | 32296183 | |
|
Intra
|
HOMER3 | Q9NSC5 | EAF1 | Homo sapiens | Q96JC9 | 21516116 | |
|
Intra
|
HOMER3 | Q9NSC5 | EAF1 | Homo sapiens | Q96JC9 | 25416956 | |
|
Intra
|
HOMER3 | Q9NSC5 | EAF1 | Homo sapiens | Q96JC9 | 25416956 | |
|
Intra
|
HOMER3 | Q9NSC5 | TBC1D22B | Homo sapiens | Q9NU19 | 32296183 | |
|
Intra
|
HOMER3 | Q9NSC5 | OTX2 | Homo sapiens | P32243-2 | 32296183 | |
|
Intra
|
HOMER3 | Q9NSC5 | OTX2 | Homo sapiens | P32243-2 | 32296183 | |
|
Intra
|
HOMER3 | Q9NSC5 | KANK4 | Homo sapiens | Q5T7N3 | 32296183 | |
|
Intra
|
HOMER3 | Q9NSC5 | KANK4 | Homo sapiens | Q5T7N3 | 32296183 |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Deafness, Autosomal Dominant 68 |
|
|
| Spinocerebellar Ataxia, Autosomal Recessive 13 |
|
|
| Schizophrenia 6 |
|
|
| Migraine, Familial Hemiplegic, 1 |
|
|
| Spinocerebellar Ataxia 1 |
|
|
| Autism |
|
|
Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Mus musculus | HOMER3 | MGD | MGI:1347359 |
| Canis familiaris | HOMER3 | VGNC | VGNC:41738 |
| Macaca mulatta | HOMER3 | VGNC | VGNC:97774 |
| Bos taurus | HOMER3 | VGNC | VGNC:29903 |
| Rattus norvegicus | HOMER3 | RGD | RGD:620706 |
| Felis catus | HOMER3 | VGNC | VGNC:101460 |
| Others | HOMER3 | NCBI |