RBM22 - RNA binding motif protein 22 Gene

Also Known as Cwc2; ZC3H16; fSAP47

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 55696

About RBM22

Cytogenetic location: 5q33.1 Genomic coordinates (GRCh38): 5:150,690,792-150,701,062 (from NCBI)

This gene has 8 transcripts (splice variants) and 235 orthologues. Ubiquitous expression in bone marrow (RPKM 24.5), lymph node (RPKM 14.8) and 25 other tissues.

Summary

This gene encodes an RNA binding protein. The encoded protein may play a role in cell division and may be involved in pre-mRNA splicing. Related pseudogenes exist on chromosomes 6, 7, 9, 13, 16, 18, and X. [provided by RefSeq, Mar 2009]

RBM22 Products (1)

mRNA Protein Name
NM_018047.3 NP_060517.1 pre-mRNA-splicing factor RBM22

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables U6 snRNA binding IDA
IDA: Inferred from direct assay
22246180 GOA
enables calcium-dependent protein binding IPI
IPI: Inferred from physical interaction
17045351 GOA
enables pre-mRNA binding IDA
IDA: Inferred from direct assay
22246180 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
Biological Process GO Annotation Evidence References Source
involved in cellular response to xenobiotic stimulus IDA
IDA: Inferred from direct assay
21122810 GOA
involved in mRNA cis splicing, via spliceosome IDA
IDA: Inferred from direct assay
22246180 GOA
involved in positive regulation of RNA splicing IDA
IDA: Inferred from direct assay
22246180 GOA
involved in positive regulation of protein export from nucleus IDA
IDA: Inferred from direct assay
21122810 GOA
involved in positive regulation of protein import into nucleus IDA
IDA: Inferred from direct assay
21122810 GOA
Cellular Component GO Annotation Evidence References Source
part of U2-type catalytic step 2 spliceosome IDA
IDA: Inferred from direct assay
28076346 GOA
part of catalytic step 2 spliceosome IDA
IDA: Inferred from direct assay
11991638 GOA
located in cytoplasm IDA
IDA: Inferred from direct assay
21122810 GOA
located in nucleus IDA
IDA: Inferred from direct assay
17045351 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RBM22 Protein Structure

RRM_1

RRM_1: RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) (234 - 298)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 420 a.a.
Protein Preferred Names Protein Names

pre-mRNA-splicing factor RBM22

  • functional spliceosome-associated protein 47

RBM22 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
RBM22 Q9NW64 NCKIPSD Homo sapiens Q9NZQ3-3
Y2H Prey Pooling
32296183
Intra
RBM22 Q9NW64 NCKIPSD Homo sapiens Q9NZQ3-3
Validated Y2H
32296183
Intra
RBM22 Q9NW64 NCKIPSD Homo sapiens Q9NZQ3-3
Y2H Array
32296183
Intra
RBM22 Q9NW64 CYSRT1 Homo sapiens A8MQ03
Y2H Prey Pooling
32296183
Intra
RBM22 Q9NW64 CYSRT1 Homo sapiens A8MQ03
Y2H Array
32296183
Intra
RBM22 Q9NW64 GOLGA2 Homo sapiens Q08379
Y2H Prey Pooling
32296183
Intra
RBM22 Q9NW64 GOLGA2 Homo sapiens Q08379
Y2H Array
32296183
Intra
RBM22 Q9NW64 CEP55 Homo sapiens Q53EZ4
Y2H Prey Pooling
25416956
Intra
RBM22 Q9NW64 CEP55 Homo sapiens Q53EZ4
Y2H Prey Pooling
32296183
Intra
RBM22 Q9NW64 CEP55 Homo sapiens Q53EZ4
Y2H Array
32296183
Intra
RBM22 Q9NW64 HOMER3 Homo sapiens Q9NSC5
Y2H Prey Pooling
32296183
Intra
RBM22 Q9NW64 HOMER3 Homo sapiens Q9NSC5
Y2H Array
32296183
Intra
RBM22 Q9NW64 GIGYF1 Homo sapiens O75420
Y2H Array
32296183
Intra
RBM22 Q9NW64 GIGYF1 Homo sapiens O75420
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Pontocerebellar Hypoplasia

  • Pch

  • Congenital Pontocerebellar Hypoplasia

  • Opch

  • Hypoplasia, Pontocerebellar

  • Pontoneocerebellar Hypoplasia

  • Nonsyndromic Pontocerebellar Hypoplasia
Microcephaly

  • Microencephaly

  • Microcephalus

  • Microcephalic

  • Nanocephaly

  • Congenital Microcephaly

  • Brain Hypoplasia

  • Brain Nondevelopment

  • Cephalic Hypoplasia

  • Undeveloped Cerebrum

  • Undeveloped Brain

  • Micrencephalon

  • Micrencephaly
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS11740 RBM22 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21724 Rbm22 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28242 Rbm22 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus RBM22 MGD MGI:1914060
Rattus norvegicus RBM22 RGD RGD:1305770
Macaca mulatta RBM22 VGNC VGNC:76535
Canis familiaris RBM22 VGNC VGNC:45415
Felis catus RBM22 VGNC VGNC:64525
Bos taurus RBM22 VGNC VGNC:33792
Others RBM22 NCBI