C1orf116 - chromosome 1 open reading frame 116 Gene

Also Known as SARG

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 79098

About C1orf116

Cytogenetic location: 1q32.1 Genomic coordinates (GRCh38): 1:207,018,522-207,032,756 (from NCBI)

This gene has 2 transcripts (splice variants) and 248 orthologues. Biased expression in lung (RPKM 46.8), esophagus (RPKM 46.0) and 10 other tissues.

Summary

Located in cytosol and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

C1orf116 Products (2)

mRNA	Protein	Name
NM_001083924.2	NP_001077393.1	specifically androgen-regulated gene protein isoform 2
NM_023938.6	NP_076427.2	specifically androgen-regulated gene protein isoform 1

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	19447967	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	15525603	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

C1orf116 Protein Structure

SARG

0
100
200
300
400
500
601 a.a.

Protein Preferred Names	Protein Names
specifically androgen-regulated gene protein	specifically androgen-regulated protein

C1orf116 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	SARG	Q9BW04	HOMER1	Homo sapiens	Q86YM7	Y2H Prey Pooling	25416956
Intra	SARG	Q9BW04	HOMER1	Homo sapiens	Q86YM7	Y2H Array	25416956
Intra	SARG	Q9BW04	HOMER3	Homo sapiens	Q9NSC5	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Fibrosarcomatous Osteosarcoma	Fibroblastic Osteosarcoma Fibrosarcomatous Osteogenic Sarcoma
Lymph Node Carcinoma	Lymph Node Cancer Lymph Node Neoplasm Neoplasm Of Lymph Node
Diaphyseal Medullary Stenosis With Malignant Fibrous Histiocytoma	DMSMFH Bone Dysplasia With Medullary Fibrosarcoma Bdmf Bone Dysplasia With Malignant Fibrous Histiocytoma Hardcastle Syndrome Diaphyseal Medullary Stenosis-Bone Malignancy Syndrome Myopathy, Limb-Girdle, With Bone Fragility Bone Dysplasia-Medullary Fibrosarcoma Syndrome Diaphyseal Medullary Stenosis-Malignant Fibrous Histiocytoma Syndrome Dms-Mfh Limb-Girdle Myopathy With Bone Fragility Stenosis, Medullary, Diaphyseal, With Malignant Fibrous Histiocytoma
Meninges Sarcoma	Meningeal Sarcoma Sarcoma Of Meninges Meningothelial Sarcoma Leptomeningeal Sarcoma
Bone Osteosarcoma	Osteosarcoma Of Bone Primary Osteosarcoma Of Bone

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01711	C1orf116 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	C1orf116	RGD	RGD:1565034
Macaca mulatta	C1orf116	VGNC	VGNC:70427
Mus musculus	C1orf116	MGD	MGI:2138143
Bos taurus	C1orf116	VGNC	VGNC:52641
Others	C1orf116	NCBI