POLI - DNA polymerase iota Gene

Also Known as eta2; RAD30B; RAD3OB

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 11201

About POLI

Cytogenetic location: 18q21.2 Genomic coordinates (GRCh38): 18:54,269,479-54,321,266 (from NCBI)

This gene has 16 transcripts (splice variants), 184 orthologues and 5 paralogues. Ubiquitous expression in thyroid (RPKM 9.1), testis (RPKM 7.6) and 25 other tissues.

Summary

The protein encoded by this gene is an error-prone DNA Polymerase involved in DNA repair. The encoded protein promotes DNA synthesis across lesions in the template DNA, which Other polymerases cannot do. The encoded polymerase inserts deoxynucleotides across lesions and then relies on DNA Polymerase zeta to extend the nascent DNA strand to bypass the lesion. [provided by RefSeq, May 2017]

POLI Products (14)

mRNA	Protein	Name
NM_001351610.1	NP_001338539.1	DNA polymerase iota isoform b
NM_001351611.2	NP_001338540.1	DNA polymerase iota isoform c
NM_001351612.2	NP_001338541.1	DNA polymerase iota isoform c
NM_001351613.1	NP_001338542.1	DNA polymerase iota isoform d
NM_001351614.2	NP_001338543.1	DNA polymerase iota isoform e
NM_001351615.2	NP_001338544.1	DNA polymerase iota isoform e
NM_001351616.1	NP_001338545.1	DNA polymerase iota isoform f
NM_001351617.2	NP_001338546.1	DNA polymerase iota isoform g precursor
NM_001351618.2	NP_001338547.1	DNA polymerase iota isoform g precursor
NM_001351619.2	NP_001338548.1	DNA polymerase iota isoform g precursor
NM_001351620.2	NP_001338549.1	DNA polymerase iota isoform h
NM_001351621.1	NP_001338550.1	DNA polymerase iota isoform i
NM_001351632.2	NP_001338561.1	DNA polymerase iota isoform a (short)
NM_007195.3	NP_009126.2	DNA polymerase iota isoform a (long)

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

POLI Protein Structure

IMS

IMS_C

0
200
400
600
740 a.a.

Protein Preferred Names	Protein Names
DNA polymerase iota	RAD30 homolog B

POLI Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	POLI	Q9UNA4	LMO3	Homo sapiens	Q8TAP4-4	Validated Y2H	32814053
Intra	POLI	Q9UNA4	LMO3	Homo sapiens	Q8TAP4-4	Y2H Pooling	32814053
Intra	POLI	Q9UNA4	LMO3	Homo sapiens	Q8TAP4-4	Y2H Array	32814053
Intra	POLI	Q9UNA4	PRKCA	Homo sapiens	P17252	Y2H Pooling	32814053
Intra	POLI	Q9UNA4	PRKCA	Homo sapiens	P17252	Validated Y2H	32814053
Intra	POLI	Q9UNA4	PRKCA	Homo sapiens	P17252	Y2H Array	32814053
Intra	POLI	Q9UNA4	UBC	Homo sapiens	P0CG48	Y2H	16763556
Intra	POLI	Q9UNA4	UBC	Homo sapiens	P0CG48	Pull Down	16763556
Intra	POLI	Q9UNA4	TRAF6	Homo sapiens	Q9Y4K3	Y2H Array	25416956
Intra	POLI	Q9UNA4	TRAF6	Homo sapiens	Q9Y4K3	Y2H Prey Pooling	25416956
Intra	POLI	Q9UNA4	YWHAG	Homo sapiens	P61981	Y2H Pooling	32814053
Intra	POLI	Q9UNA4	YWHAG	Homo sapiens	P61981	Validated Y2H	32814053
Intra	POLI	Q9UNA4	YWHAG	Homo sapiens	P61981	Y2H Array	32814053
Intra	POLI	Q9UNA4	KAT5	Homo sapiens	Q92993	Validated Y2H	32814053
Intra	POLI	Q9UNA4	KAT5	Homo sapiens	Q92993	Y2H Array	32814053
Intra	POLI	Q9UNA4	KAT5	Homo sapiens	Q92993	Y2H Pooling	32814053
Intra	POLI	Q9UNA4	ZBTB44	Homo sapiens	Q8NCP5	Y2H Prey Pooling	25416956
Intra	POLI	Q9UNA4	ZBTB44	Homo sapiens	Q8NCP5	Y2H Array	25416956
Intra	POLI	Q9UNA4	DAZAP2	Homo sapiens	Q15038	Y2H Array	19060904
Intra	POLI	Q9UNA4	DAZAP2	Homo sapiens	Q15038	Y2H Pooling	19060904
Intra	POLI	Q9UNA4	TRIM39	Homo sapiens	Q9HCM9	Y2H Array	25416956
Intra	POLI	Q9UNA4	TRIM39	Homo sapiens	Q9HCM9	Y2H Prey Pooling	25416956
Intra	POLI	Q9UNA4	TRIM39	Homo sapiens	Q9HCM9	Y2H	21516116
Intra	POLI	Q9UNA4	HOMER3	Homo sapiens	Q9NSC5	Y2H Prey Pooling	32296183
Intra	POLI	Q9UNA4	HOMER3	Homo sapiens	Q9NSC5	Y2H Array	32296183
Intra	POLI	Q9UNA4	PCNA	Homo sapiens	Q6FI35	Pull Down	16763556
Intra	POLI	Q9UNA4	SETDB1	Homo sapiens	Q15047-2	Validated Y2H	32814053
Intra	POLI	Q9UNA4	SETDB1	Homo sapiens	Q15047-2	Y2H Pooling	32814053
Intra	POLI	Q9UNA4	SETDB1	Homo sapiens	Q15047-2	Y2H Array	32814053
Intra	POLI	Q9UNA4	XRCC1	Homo sapiens	P18887	Anti Tag CoIP	18923427
Intra	POLI	Q9UNA4	TMEM239	Homo sapiens	Q8WW34	Y2H Array	25416956
Intra	POLI	Q9UNA4	TMEM239	Homo sapiens	Q8WW34	Y2H Prey Pooling	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Xeroderma Pigmentosum, Variant Type	Xeroderma Pigmentosum XPV Xeroderma Pigmentosum Variant Type Xeroderma Pigmentosum With Normal Dna Repair Rates Photosensitivity With Defective Dna Synthesis Xp De Sanctis-Cacchione Syndrome Desanctis-Cacchione Syndrome Xeroderma Pigmentosa Xerodermic Idiocy Xeroderma Pigmentosum Variant Xp - [Xeroderma Pigmentosum] Atrophoderma Pigmentosum
Acrofacial Dysostosis, Cincinnati Type	Acrofacial Dysostosis Cincinnati Type AFDCIN Dysostosis, Acrofacial, Cincinnati Type
Epithelial-Stromal Tgfbi Dystrophy
Lattice Corneal Dystrophy	Familial Amyloid Neuropathy, Finnish Type Familial Amyloid Polyneuropathy, Type V
Mouth Disease	Mouth Diseases Mouth Disorders
Multiple Personality Disorder	Dissociative Identity Disorder Multiple Personality
Rapp-Hodgkin Syndrome	RHS Anhidrotic Ectodermal Dysplasia With Cleft Lip/Palate Ectodermal Dysplasia, Rapp-Hodgkin Type Rapp-Hodgkin Ectodermal Dysplasia Syndrome Ectodermal Dysplasia, Anhidrotic, With Cleft Lip/Palate Ectodermal Dysplasia Syndrome, Rapp-Hodgkin Type Edrh Rapp-Hodgkin Ectodermal Dysplasia Orofacial Cleft 8
Sleeping Sickness	African Trypanosomiasis African Sleeping Sickness Trypanosomiasis, Human East-African Trypanosomiasis, East African Trypanosomiasis African Trypanosomiasis, African Human African Trypanosomiasis
Tremor, Hereditary Essential, 2	ETM2 Essential Tremor 2 Essential Tremor, Hereditary, 2 Hereditary Essential Tremor 2 Tremor Hereditary Essential, 2
Oppositional Defiant Disorder	Disorder Oppositional Defiance Behavioural Disorder Oppositional Defiance Disruptive Mood Dysregulation Disorder
Immunodeficiency 25	Immunodeficiency Due To Defect In Cd3-Zeta IMD25 Immunodeficiency, Type 25
Prosopagnosia
Alexithymia
Developmental Coordination Disorder	Motor Skills Disorders
Treacher Collins Syndrome 1	Treacher Collins Syndrome Mandibulofacial Dysostosis Treacher Collins-Franceschetti Syndrome Tcof Tcs Mfd1 Franceschetti-Klein Syndrome TCS1 Franceschetti Syndrome Franceschetti-Zwahlen-Klein Syndrome Zygoauromandibular Dysplasia Treacher-Collins Syndrome Mandibulofacial Dysostosis Without Limb Anomalies Bilateral And Symmetric Oto-Mandibular Dysplasia
Reading Disorder	Specific Reading Disorder Reading Dyslexia Developmental Reading Disorder
Anauxetic Dysplasia 1	Anauxetic Dysplasia Spondylometaepiphyseal Dysplasia, Menger Type Spondylometaepiphyseal Dysplasia, Anauxetic Type Spondyloepimetaphyseal Dysplasia, Anauxetic Type ANXD1 Anxd Spondylometaepiphyseal Dysplasia Anauxetic Type Spondylometaepiphyseal Dysplasia Menger Type Ad Spondyloepimetaphyseal Dysplasia, Menger Type Dysplasia, Anauxetic, Type 1
Cockayne Syndrome B	Cockayne Syndrome Type 2 Cockayne Syndrome, Type B Cockayne Syndrome Type Ii CSB Cockayne Syndrome 2 Cockayne Syndrome Type B Ckn2 Cockayne Syndrome, Type Ii
Cartilage-Hair Hypoplasia	Metaphyseal Chondrodysplasia, Mckusick Type CHH Mckusick Type Metaphyseal Chondrodysplasia Metaphyseal Dysplasia Without Hypotrichosis Cartilage Hair Hypoplasia Like Syndrome Metaphyseal Chondrodysplasia Mckusick Type Chhv Cartilage-Hair Hypoplasia Variant, Skeletal Manifestations Only Cartilage-Hair Hypoplasia-Like Skeletal Dysplasia Without Hypotrichosis Or Immunodeficiency Cartilage-Hair Syndrome Mckusick'S Metaphyseal Chondrodysplasia Syndrome Metaphyseal Chondrodysplasia, Recessive Type Autosomal Recessive Metaphyseal Chondrodysplasia
Learning Disability	Learning Disabilities Learning Disorders Academic Skill Disorder Learning Disorder
Diamond-Blackfan Anemia	Congenital Pure Red Cell Aplasia Aase Syndrome Erythrogenesis Imperfecta Anemia, Diamond-Blackfan Congenital Hypoplastic Anemia Aase-Smith Ii Syndrome Bds Blackfan-Diamond Anemia Congenital Prca Congenital Hypoplastic Anemia, Blackfan-Diamond Type Dba Blackfan - Diamond Syndrome Chronic Constitutional Pure Red Cell Anaemia Anemia Diamond Blackfan Type Anemia Congenital Erythroid Hypoplastic Aregenerative Anemia Chronic Congenital Blackfan Diamond Syndrome Red Cell Aplasia, Pure Hereditary Aase-Smith Syndrome Ii Bda Blackfan Diamond Anemia Blackfan-Diamond Disease Blackfan-Diamond Syndrome Chronic Congenital Agenerative Anemia Congenital Erythroid Hypoplastic Anemia Congenital Hypoplastic Anemia Of Blackfan And Diamond Congenital Pure Red Cell Anemia Hypoplastic Congenital Anemia Inherited Erythroblastopenia Pure Hereditary Red Cell Aplasia Anemia, Hypoplastic, Congenital Anemia Hypoplastic Congenital Fanconi Anemia Constitutional Aplastic Anemia Diamond-Blackfan Anemia 1 Aase Smith Syndrome 2 Congenital Red Cell Aplasia Red Cell Aplasia Of Infants Pure Red Cell Aplasia Of Infants Congenital Red Cell Aplastic Anaemia Congenital Pure Red Cell Anaemia Congenital Erythroid Hypoplasia Pearson Marrow-Pancreas Syndrome
Specific Language Impairment	Language Impairment, Specific
Stuttering	Stammering Familial Persistent Stuttering Stuttering, Familial Persistent 1
Dyslexia
Hypomyelinating Leukodystrophy	Hld Leukodystrophy, Hypomyelinating
Attention Deficit-Hyperactivity Disorder	Attention Deficit Hyperactivity Disorder ADHD Attention Deficit Disorder Attention Deficit-Hyperactivity Disorder, Susceptibility To Attention Deficit Disorder With Hyperactivity Hyperkinetic Disorder Hyperactivity Of Childhood Attention-Deficit/Hyperactivity Disorder Add Addh Attention Deficit Attention Deficit Disorder Of Childhood With Hyperactivity Attention Deficit Disorder With Hyperactivity Syndrome Hyperkinetic Syndrome Attention-Deficit Hyperactivity Disorder Attention-Deficit/Hyperactivity Disorder, Predominantly Inattentive Type Disturbance Of Activity And Attention Disorder Of Activity And Attention Adhd - [Attention Deficit Hyperactivity Disorder] Hyperkinetic Disorders Disorder Of Activity And Attention With Hyperkinesia Attention Deficit Syndrome With Hyperactivity
Dyskeratosis Congenita	Dyskeratosis Congenita Autosomal Dominant Dc Dkc Zinsser-Engman-Cole Syndrome Dyskeratosis Congenita, Autosomal Dominant Autosomal Dominant Dyskeratosis Congenita Dkca Dyskeratosis Congenita Scoggins Type Zinsser-Cole-Engman Syndrome X-Linked Dyskeratosis Congenita Hoyeraal-Hreidarsson Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-121678	Tetridamine		99.79%	Unkown
HY-RS10832	POLI Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17247	Poli Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23701	Poli Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	POLI	VGNC	VGNC:44784
Felis catus	POLI	VGNC	VGNC:80465
Rattus norvegicus	POLI	RGD	RGD:1305212
Bos taurus	POLI	VGNC	VGNC:33125
Mus musculus	POLI	MGD	MGI:1347081
Macaca mulatta	POLI	VGNC	VGNC:76208
Others	POLI	NCBI