KANK4 - KN motif and ankyrin repeat domains 4 Gene

Also Known as ANKRD38; dJ1078M7.1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 163782

About KANK4

Cytogenetic location: 1p31.3 Genomic coordinates (GRCh38): 1:62,236,165-62,319,434 (from NCBI)

This gene has 4 transcripts (splice variants), 296 orthologues and 3 paralogues. Biased expression in fat (RPKM 7.4), placenta (RPKM 5.9) and 10 other tissues.

Summary

Predicted to be involved in negative regulation of actin filament polymerization. Located in cytosol and microtubule Cytoskeleton. [provided by Alliance of Genome Resources, Apr 2022]

KANK4 Products (2)

mRNA Protein Name
NM_001320269.2 NP_001307198.1 KN motif and ankyrin repeat domain-containing protein 4 isoform 2
NM_181712.5 NP_859063.3 KN motif and ankyrin repeat domain-containing protein 4 isoform 1

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
25961457 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

KANK4 Protein Structure

KN_motif

KN_motif: KN motif (24 - 62)

Ank_2

Ank_2: Ankyrin repeats (3 copies) (815 - 864)

Ank_2

Ank_2: Ankyrin repeats (3 copies) (870 - 951)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 995 a.a.
Protein Preferred Names Protein Names

KN motif and ankyrin repeat domain-containing protein 4

  • ankyrin repeat domain 38

KANK4 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
KANK4 Q5T7N3 CUL5 Homo sapiens Q93034
Validated Y2H
32296183
Intra
KANK4 Q5T7N3 MYLIP Homo sapiens Q8WY64
Validated Y2H
32296183
Intra
KANK4 Q5T7N3 HOMER3 Homo sapiens Q9NSC5
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Nephrotic Syndrome

  • Finnish Congenital Nephrotic Syndrome

  • Ns - [Nephrotic Syndrome]

  • Nephrosis Syndrome

  • Nephrosis Nos

  • Glomerular Lesion Nephrosis
Corneal Endothelial Dystrophy

  • Congenital Hereditary Endothelial Dystrophy Of Cornea

  • Chandler Syndrome

  • CHED

  • Chandler'S Syndrome

  • Endothelial Corneal Dystrophy

  • Ched2

  • Maumenee Corneal Dystrophy

  • Corneal Dystrophy, Congenital Hereditary Endothelial

  • Dystrophy Of Corneal Endothelium

  • Corneal Endothelial Dystrophy 2

  • Corneal Endothelial Dystrophy 2, Autosomal Recessive, Formerly

  • Ched2, Formerly

  • Corneal Endothelial Dystrophy, Autosomal Recessive

  • Endothelial Dystrophy

  • Posterior Membrane Corneal Dystrophy

  • Corneal Endothelial Dystrophy Type 2

  • Congenital Hereditary Endothelial Dystrophy Of The Cornea

  • Congenital Hereditary Endothelial Dystrophy Type Ii

  • Autosomal Recessive Ched

  • Autosomal Recessive Congenital Hereditary Endothelial Dystrophy

  • Chedii

  • Congenital Hereditary Endothelial Dystrophy Type 2

  • Infantile Hereditary Endothelial Dystrophy

  • Congenital Hereditary Endothelial Corneal Dystrophy

  • Corneal Endothelial Dystrophy 2, Autosomal Recessive

  • Iridocorneal Endothelial Syndrome

  • Dystrophy, Corneal, Endothelial

  • Corneal Endothelial Dystrophy 1, Autosomal Dominant
Corneal Dystrophy And Perceptive Deafness

  • Corneal Dystrophy-Perceptive Deafness Syndrome

  • CDPD

  • Harboyan Syndrome

  • Cdpd1

  • Corneal Dystrophy And Sensorineural Deafness

  • Corneal Endothelial Dystrophy And Perceptive Deafness

  • Corneal Dystrophy With Progressive Deafness

  • Congenital Corneal Dystrophy, Progressive Sensorineural Deafness

  • Corneal Dystrophy With Progressive Hearing Loss

  • Corneal Dystrophy-Perceptive Hearing Loss Syndrome

  • Dystrophy, Corneal, Endothelial, And Perceptive Deafness
Fuchs' Endothelial Dystrophy

  • Fuchs Endothelial Corneal Dystrophy

  • Fuchs Endothelial Dystrophy

  • Fuchs Dystrophy

  • Fced

  • Fuchs' Corneal Dystrophy

  • Fuchs' Endothelial Corneal Dystrophy

  • Fuchs Atrophy

  • Fuchs Corneal Dystrophy

  • Endoepithelial Corneal Dystrophy

  • Fecd

  • Late Hereditary Endothelial Dystrophy

  • Corneal Dystrophy, Fuchs Endothelial

  • Dystrophy, Corneal, Fuchs Endothelial

  • Corneal Dystrophy, Fuchs' Endothelial, 1
Hypertensive Encephalopathy

  • Encephalopathy, Hypertensive
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS07066 KANK4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus KANK4 VGNC VGNC:55243
Canis familiaris KANK4 VGNC VGNC:42203
Mus musculus KANK4 MGD MGI:3043381
Rattus norvegicus KANK4 RGD RGD:1307635
Felis catus KANK4 VGNC VGNC:63017
Macaca mulatta KANK4 VGNC VGNC:73916
Others KANK4 NCBI