ZBTB4 - zinc finger and BTB domain containing 4 Gene

Also Known as ZNF903; KAISO-L1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 57659

About ZBTB4

Cytogenetic location: 17p13.1 Genomic coordinates (GRCh38): 17:7,459,378-7,484,249 (from NCBI)

This gene has 2 transcripts (splice variants), 1 gene allele, 191 orthologues and 2 paralogues. Ubiquitous expression in ovary (RPKM 24.8), thyroid (RPKM 20.6) and 25 other tissues.

Summary

Enables several functions, including DNA-binding transcription repressor activity, RNA polymerase II-specific; methyl-CpNpG binding activity; and sequence-specific DNA binding activity. Involved in cellular response to DNA damage stimulus and negative regulation of transcription by RNA polymerase II. Located in cytosol and nuclear body. [provided by Alliance of Genome Resources, Apr 2022]

ZBTB4 Products (2)

mRNA Protein Name
NM_001128833.2 NP_001122305.1 zinc finger and BTB domain-containing protein 4
NM_020899.4 NP_065950.2 zinc finger and BTB domain-containing protein 4

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
16354688 GOA
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
16354688 GOA
enables methyl-CpG binding IDA
IDA: Inferred from direct assay
16354688 GOA
enables methyl-CpNpG binding IDA
IDA: Inferred from direct assay
20403812 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
16354688 GOA
enables protein homodimerization activity IDA
IDA: Inferred from direct assay
16354688 GOA
enables protein kinase binding IPI
IPI: Inferred from physical interaction
19448668 GOA
enables sequence-specific DNA binding IDA
IDA: Inferred from direct assay
20403812 GOA
Biological Process GO Annotation Evidence References Source
involved in DNA damage response IDA
IDA: Inferred from direct assay
19448668 GOA
involved in negative regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
16354688 GOA
involved in negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
16354688 GOA
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
16354688 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ZBTB4 Protein Structure

BTB

BTB: BTB/POZ domain (20 - 61)

zf-C2H2_4

zf-C2H2_4: C2H2-type zinc finger (235 - 256)

zf-C2H2

zf-C2H2: Zinc finger, C2H2 type (309 - 331)

zf-C2H2_4

zf-C2H2_4: C2H2-type zinc finger (726 - 748)

zf-C2H2_4

zf-C2H2_4: C2H2-type zinc finger (765 - 783)

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  • 800
  • 1013 a.a.
Protein Preferred Names Protein Names

zinc finger and BTB domain-containing protein 4

  • KAISO-like zinc finger protein 1

ZBTB4 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
ZBTB4 Q9P1Z0 CCDC57 Homo sapiens Q2TAC2-2
Y2H Prey Pooling
32296183
Intra
ZBTB4 Q9P1Z0 CCDC57 Homo sapiens Q2TAC2-2
Y2H Array
32296183
Intra
ZBTB4 Q9P1Z0 BANP Homo sapiens Q8N9N5-2
Y2H Array
32296183
Intra
ZBTB4 Q9P1Z0 BANP Homo sapiens Q8N9N5-2
Y2H Prey Pooling
32296183
Intra
ZBTB4 Q9P1Z0 TP53BP2 Homo sapiens Q05BL1
Y2H Prey Pooling
32296183
Intra
ZBTB4 Q9P1Z0 TP53BP2 Homo sapiens Q05BL1
Y2H Array
32296183
Intra
ZBTB4 Q9P1Z0 POU6F2 Homo sapiens P78424
Y2H Array
32296183
Intra
ZBTB4 Q9P1Z0 POU6F2 Homo sapiens P78424
Y2H Prey Pooling
32296183
Intra
ZBTB4 Q9P1Z0 PIBF1 Homo sapiens Q4G0R1
Y2H Array
32296183
Intra
ZBTB4 Q9P1Z0 PIBF1 Homo sapiens Q4G0R1
Y2H Prey Pooling
32296183
Intra
ZBTB4 Q9P1Z0 CYSRT1 Homo sapiens A8MQ03
Y2H Prey Pooling
32296183
Intra
ZBTB4 Q9P1Z0 CYSRT1 Homo sapiens A8MQ03
Y2H Array
32296183
Intra
ZBTB4 Q9P1Z0 GOLGA2 Homo sapiens Q08379
Y2H Prey Pooling
32296183
Intra
ZBTB4 Q9P1Z0 GOLGA2 Homo sapiens Q08379
Y2H Array
32296183
Intra
ZBTB4 Q9P1Z0 CALCOCO2 Homo sapiens Q13137
Y2H Array
32296183
Intra
ZBTB4 Q9P1Z0 CALCOCO2 Homo sapiens Q13137
Y2H Prey Pooling
32296183
Intra
ZBTB4 Q9P1Z0 CEP70 Homo sapiens Q8NHQ1
Y2H Prey Pooling
32296183
Intra
ZBTB4 Q9P1Z0 CEP70 Homo sapiens Q8NHQ1
Y2H Array
32296183
Intra
ZBTB4 Q9P1Z0 TRIM23 Homo sapiens P36406
Y2H Prey Pooling
32296183
Intra
ZBTB4 Q9P1Z0 TRIM23 Homo sapiens P36406
Y2H Array
32296183
Intra
ZBTB4 Q9P1Z0 KLHL12 Homo sapiens Q53G59
Y2H Prey Pooling
32296183
Intra
ZBTB4 Q9P1Z0 KLHL12 Homo sapiens Q53G59
Y2H Array
32296183
Intra
ZBTB4 Q9P1Z0 CEP76 Homo sapiens Q8TAP6
Y2H Array
32296183
Intra
ZBTB4 Q9P1Z0 CEP76 Homo sapiens Q8TAP6
Y2H Prey Pooling
32296183
Intra
ZBTB4 Q9P1Z0 HOMER3 Homo sapiens Q9NSC5
Y2H Prey Pooling
32296183
Intra
ZBTB4 Q9P1Z0 HOMER3 Homo sapiens Q9NSC5
Y2H Array
32296183
Intra
ZBTB4 Q9P1Z0 PDE4DIP Homo sapiens Q5VU43-2
Y2H Prey Pooling
32296183
Intra
ZBTB4 Q9P1Z0 PDE4DIP Homo sapiens Q5VU43-2
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Immunodeficiency-Centromeric Instability-Facial Anomalies Syndrome

  • Icf Syndrome

  • Immunodeficiency Syndrome, Variable

  • Ciid

  • Centromeric Instability, Immunodeficiency Syndrome

  • Immune Deficiency, Variable, With Centromeric Instability Of Chromosomes 1, 9, And 16

  • Icf
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS15974 ZBTB4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta ZBTB4 VGNC VGNC:79414
Canis familiaris ZBTB4 VGNC VGNC:53483
Rattus norvegicus ZBTB4 RGD RGD:1307184
Felis catus ZBTB4 VGNC VGNC:99577
Bos taurus ZBTB4 VGNC VGNC:37078
Mus musculus ZBTB4 MGD MGI:1922830
Others ZBTB4 NCBI