ZBTB22 - zinc finger and BTB domain containing 22 Gene

Also Known as fru; BING1; ZNF297; ZBTB22A; ZNF297A; fruitless

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 9278

Summary

Enables sequence-specific double-stranded DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in chromatin. [provided by Alliance of Genome Resources, Jul 2025]
Ubiquitous expression in ovary (RPKM 7.3), thyroid (RPKM 7.3) and 25 other tissues.

ZBTB22 Products (2)

mRNA Protein Name
NM_001145338.2 NP_001138810.1 zinc finger and BTB domain-containing protein 22
NM_005453.5 NP_005444.4 zinc finger and BTB domain-containing protein 22

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
enables sequence-specific double-stranded DNA binding IDA
IDA: Inferred from direct assay
28473536 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ZBTB22 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
ZBTB22 O15209 a8ka83_human Homo sapiens A8KA83
Validated Y2H
25416956
Intra
ZBTB22 O15209 GAS8 Homo sapiens O95995
Validated Y2H
32296183
Intra
ZBTB22 O15209 VAPA Homo sapiens Q9P0L0
Validated Y2H
32296183
Intra
ZBTB22 O15209 CCDC13 Homo sapiens Q8IYE1
Validated Y2H
32296183
Intra
ZBTB22 O15209 MEMO1 Homo sapiens Q9Y316
Validated Y2H
32296183
Intra
ZBTB22 O15209 VAPB Homo sapiens O95292
Validated Y2H
32296183
Intra
ZBTB22 O15209 MCRS1 Homo sapiens Q96EZ8
Validated Y2H
32296183
Intra
ZBTB22 O15209 MCRS1 Homo sapiens Q96EZ8
Y2H Array
25416956
Intra
ZBTB22 O15209 MCRS1 Homo sapiens Q96EZ8
Y2H Prey Pooling
25416956
Intra
ZBTB22 O15209 MCRS1 Homo sapiens Q96EZ8
Validated Y2H
25416956
Intra
ZBTB22 O15209 MLLT6 Homo sapiens Q6P2C6
Y2H Array
25416956
Intra
ZBTB22 O15209 MLLT6 Homo sapiens Q6P2C6
Y2H Prey Pooling
25416956
Intra
ZBTB22 O15209 TCEA2 Homo sapiens Q15560
Validated Y2H
32296183
Intra
ZBTB22 O15209 PIN1 Homo sapiens Q13526
Y2H Array
25416956
Intra
ZBTB22 O15209 FXR2 Homo sapiens P51116
Y2H Prey Pooling
25416956
Intra
ZBTB22 O15209 GABARAPL1 Homo sapiens Q9H0R8
Validated Y2H
32296183
Intra
ZBTB22 O15209 GABARAPL1 Homo sapiens Q9H0R8
Complementation
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (9)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS15968 ZBTB20 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS15962 ZBTB12 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS15967 ZBTB2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS15969 ZBTB24 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS15971 ZBTB32 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19758 Zbtb2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21977 Zbtb12 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26255 Zbtb2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28494 Zbtb12 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown