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SYTL4 - synaptotagmin like 4 Gene

Also Known as SLP4

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 94121

About SYTL4

Cytogenetic location: Xq22.1 Genomic coordinates (GRCh38): X:100,674,491-100,732,121 (from NCBI)

This gene has 6 transcripts (splice variants), 204 orthologues and 31 paralogues. Broad expression in ovary (RPKM 19.6), endometrium (RPKM 12.8) and 19 other tissues.

Summary

This gene encodes a member of the synaptotagmin like protein family. Members of this family are characterized by an N-terminal Rab27 binding domain and C-terminal tandem C2 domains. The encoded protein binds specific small Rab GTPases and is involved in intracellular membrane trafficking. This protein binds Rab27 and may be involved in inhibiting dense core vesicle exocytosis. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Mar 2010]

SYTL4 Products (13)

mRNA	Protein	Name
NM_001129896.3	NP_001123368.1	synaptotagmin-like protein 4 isoform 1
NM_001174068.2	NP_001167539.1	synaptotagmin-like protein 4 isoform 1
NM_001370160.1	NP_001357089.1	synaptotagmin-like protein 4 isoform 1
NM_001370161.1	NP_001357090.1	synaptotagmin-like protein 4 isoform 1
NM_001370162.1	NP_001357091.1	synaptotagmin-like protein 4 isoform 2
NM_001370163.1	NP_001357092.1	synaptotagmin-like protein 4 isoform 1
NM_001370164.1	NP_001357093.1	synaptotagmin-like protein 4 isoform 1
NM_001370165.1	NP_001357094.1	synaptotagmin-like protein 4 isoform 1
NM_001370166.1	NP_001357095.1	synaptotagmin-like protein 4 isoform 1
NM_001370167.1	NP_001357096.1	synaptotagmin-like protein 4 isoform 1
NM_001370168.1	NP_001357097.1	synaptotagmin-like protein 4 isoform 1
NM_001370169.1	NP_001357098.1	synaptotagmin-like protein 4 isoform 1
NM_080737.3	NP_542775.2	synaptotagmin-like protein 4 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in lysosome localization	IMP IMP: Inferred from mutant phenotype	2732579	GOA
involved in multivesicular body sorting pathway	IMP IMP: Inferred from mutant phenotype	19966785	GOA
involved in plasma membrane repair	IDA IDA: Inferred from direct assay	27325790	GOA
involved in positive regulation of exocytosis	IMP IMP: Inferred from mutant phenotype	19966785	GOA
involved in positive regulation of protein secretion	IMP IMP: Inferred from mutant phenotype	19966785	GOA
involved in regulation of plasma membrane repair	IMP IMP: Inferred from mutant phenotype	2732579	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in endosome	IDA IDA: Inferred from direct assay	19966785	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SYTL4 Protein Structure

FYVE_2

0
200
400
600
671 a.a.

Protein Preferred Names	Protein Names
synaptotagmin-like protein 4	exophilin-2

SYTL4 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	SYTL4	Q96C24	OSBPL3	Homo sapiens	Q9H4L5	Y2H Prey Pooling	32296183
Intra	SYTL4	Q96C24	OSBPL3	Homo sapiens	Q9H4L5	Validated Y2H	32296183
Intra	SYTL4	Q96C24	OSBPL3	Homo sapiens	Q9H4L5	Y2H Array	32296183
Intra	SYTL4	Q96C24	FCHO1	Homo sapiens	A0A0C3SFZ9	Y2H Prey Pooling	32296183
Intra	SYTL4	Q96C24	FCHO1	Homo sapiens	A0A0C3SFZ9	Y2H Array	32296183
Intra	SYTL4	Q96C24	LZTS1	Homo sapiens	Q9Y250	Y2H Prey Pooling	32296183
Intra	SYTL4	Q96C24	LZTS1	Homo sapiens	Q9Y250	Validated Y2H	32296183
Intra	SYTL4	Q96C24	LZTS1	Homo sapiens	Q9Y250	Y2H Array	32296183
Intra	SYTL4	Q96C24	ROPN1	Homo sapiens	Q9HAT0	Validated Y2H	32296183
Intra	SYTL4	Q96C24	ROPN1	Homo sapiens	Q9HAT0	Y2H Prey Pooling	32296183
Intra	SYTL4	Q96C24	ROPN1	Homo sapiens	Q9HAT0	Y2H Array	32296183
Intra	SYTL4	Q96C24	KIFC3	Homo sapiens	Q9BVG8-5	Y2H Prey Pooling	32296183
Intra	SYTL4	Q96C24	KIFC3	Homo sapiens	Q9BVG8-5	Validated Y2H	32296183
Intra	SYTL4	Q96C24	KIFC3	Homo sapiens	Q9BVG8-5	Y2H Array	32296183
Intra	SYTL4	Q96C24	TBC1D1	Homo sapiens	Q86TI0	Y2H Array	32296183
Intra	SYTL4	Q96C24	TBC1D1	Homo sapiens	Q86TI0	Y2H Prey Pooling	32296183
Intra	SYTL4	Q96C24	PRKAR1B	Homo sapiens	P31321	Y2H Array	32296183
Intra	SYTL4	Q96C24	PRKAR1B	Homo sapiens	P31321	Y2H Prey Pooling	32296183
Intra	SYTL4	Q96C24	ZBTB9	Homo sapiens	Q96C00	Y2H Prey Pooling	32296183
Intra	SYTL4	Q96C24	ZBTB9	Homo sapiens	Q96C00	Y2H Array	32296183
Intra	SYTL4	Q96C24	ZRANB1	Homo sapiens	Q9UGI0	Y2H Prey Pooling	32296183
Intra	SYTL4	Q96C24	ZRANB1	Homo sapiens	Q9UGI0	Validated Y2H	32296183
Intra	SYTL4	Q96C24	ZRANB1	Homo sapiens	Q9UGI0	Y2H Array	32296183
Intra	SYTL4	Q96C24	TRIM41	Homo sapiens	Q8WV44	Y2H Array	32296183
Intra	SYTL4	Q96C24	TRIM41	Homo sapiens	Q8WV44	Y2H Prey Pooling	32296183
Intra	SYTL4	Q96C24	CEP70	Homo sapiens	Q8NHQ1	Y2H Prey Pooling	25416956
Intra	SYTL4	Q96C24	DVL3	Homo sapiens	Q92997	Y2H Array	32296183
Intra	SYTL4	Q96C24	ZBTB7B	Homo sapiens	O15156	Validated Y2H	25416956
Intra	SYTL4	Q96C24	ZBTB7B	Homo sapiens	O15156	Y2H Prey Pooling	25416956
Intra	SYTL4	Q96C24	FXR2	Homo sapiens	P51116	Y2H Prey Pooling	32296183
Intra	SYTL4	Q96C24	FXR2	Homo sapiens	P51116	Y2H Array	32296183
Intra	SYTL4	Q96C24	HMG20A	Homo sapiens	Q9NP66	Y2H Prey Pooling	25416956
Intra	SYTL4	Q96C24	HMG20A	Homo sapiens	Q9NP66	Validated Y2H	25416956
Intra	SYTL4	Q96C24	HMG20A	Homo sapiens	Q9NP66	Y2H Prey Pooling	32296183
Intra	SYTL4	Q96C24	HMG20A	Homo sapiens	Q9NP66	Validated Y2H	32296183
Intra	SYTL4	Q96C24	HMG20A	Homo sapiens	Q9NP66	Y2H Array	32296183
Intra	SYTL4	Q96C24	TRIM37	Homo sapiens	O94972	Y2H Prey Pooling	32296183
Intra	SYTL4	Q96C24	TRIM37	Homo sapiens	O94972	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Early Infantile Epileptic Encephalopathy	Early Infantile Epileptic Encephalopathy With Burst-Suppression Early Infantile Epileptic Encephalopathy With Suppression Bursts Eiee Early Infantile Epileptic Encephalopathy With Suppression-Bursts Ohtahara Syndrome Encephalopathy, Epileptic, Early Infantile

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14125	SYTL4 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	SYTL4	VGNC	VGNC:47053
Macaca mulatta	SYTL4	VGNC	VGNC:78124
Mus musculus	SYTL4	MGD	MGI:1351606
Rattus norvegicus	SYTL4	RGD	RGD:620204
Felis catus	SYTL4	VGNC	VGNC:65907
Bos taurus	SYTL4	VGNC	VGNC:35548
Others	SYTL4	NCBI