SYTL4 - synaptotagmin like 4 Gene

Homo sapiens

Also known as SLP4

Gene ID: 94121 | Gene type: protein coding

About SYTL4

Cytogenetic location: Xq22.1 Genomic coordinates (GRCh38): X:100,674,491-100,732,121 (from NCBI)

This gene has 6 transcripts (splice variants), 204 orthologues and 31 paralogues. Broad expression in ovary (RPKM 19.6), endometrium (RPKM 12.8) and 19 other tissues.

Summary

This gene encodes a member of the synaptotagmin like protein family. Members of this family are characterized by an N-terminal Rab27 binding domain and C-terminal tandem C2 domains. The encoded protein binds specific small Rab GTPases and is involved in intracellular membrane trafficking. This protein binds Rab27 and may be involved in inhibiting dense core vesicle exocytosis. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Mar 2010]

SYTL4 Products(13)

mRNA	Protein	Name
NM_001129896.3	NP_001123368.1	synaptotagmin-like protein 4 isoform 1
NM_001174068.2	NP_001167539.1	synaptotagmin-like protein 4 isoform 1
NM_001370160.1	NP_001357089.1	synaptotagmin-like protein 4 isoform 1
NM_001370161.1	NP_001357090.1	synaptotagmin-like protein 4 isoform 1
NM_001370162.1	NP_001357091.1	synaptotagmin-like protein 4 isoform 2
NM_001370163.1	NP_001357092.1	synaptotagmin-like protein 4 isoform 1
NM_001370164.1	NP_001357093.1	synaptotagmin-like protein 4 isoform 1
NM_001370165.1	NP_001357094.1	synaptotagmin-like protein 4 isoform 1
NM_001370166.1	NP_001357095.1	synaptotagmin-like protein 4 isoform 1
NM_001370167.1	NP_001357096.1	synaptotagmin-like protein 4 isoform 1
NM_001370168.1	NP_001357097.1	synaptotagmin-like protein 4 isoform 1
NM_001370169.1	NP_001357098.1	synaptotagmin-like protein 4 isoform 1
NM_080737.3	NP_542775.2	synaptotagmin-like protein 4 isoform 1

SYTL4 Protein Structure

FYVE_2

0
200
400
600
671 a.a.

Protein Preferred Names

Protein Names

synaptotagmin-like protein 4

exophilin-2

Related Diseases

Diseases

Alias

Early Infantile Epileptic Encephalopathy

Early Infantile Epileptic Encephalopathy With Burst-Suppression	Early Infantile Epileptic Encephalopathy With Suppression Bursts
Eiee	Early Infantile Epileptic Encephalopathy With Suppression-Bursts
Ohtahara Syndrome	Encephalopathy, Epileptic, Early Infantile

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14125	SYTL4 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	SYTL4	VGNC	VGNC:47053
Macaca mulatta	SYTL4	VGNC	VGNC:78124
Mus musculus	SYTL4	MGD	MGI:1351606
Rattus norvegicus	SYTL4	RGD	RGD:620204
Felis catus	SYTL4	VGNC	VGNC:65907
Bos taurus	SYTL4	VGNC	VGNC:35548

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