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MORF4L1 - mortality factor 4 like 1 Gene

Also Known as Eaf3; MEAF3; MRG15; FWP006; S863-6; HsT17725; MORFRG15

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 10933

About MORF4L1

Cytogenetic location: 15q25.1 Genomic coordinates (GRCh38): 15:78,872,890-78,898,139 (from NCBI)

This gene has 23 transcripts (splice variants), 280 orthologues and 2 paralogues. Ubiquitous expression in testis (RPKM 192.5), brain (RPKM 119.7) and 25 other tissues.

Summary

Enables protein N-terminus binding activity. Involved in double-strand break repair via homologous recombination and histone modification. Located in nuclear speck. Part of NuA4 Histone Acetyltransferase complex and Sin3 complex. [provided by Alliance of Genome Resources, Apr 2022]

MORF4L1 Products (5)

mRNA	Protein	Name
NM_001265603.2	NP_001252532.1	mortality factor 4-like protein 1 isoform 3
NM_001265604.2	NP_001252533.1	mortality factor 4-like protein 1 isoform 3
NM_001265605.2	NP_001252534.1	mortality factor 4-like protein 1 isoform 3
NM_006791.4	NP_006782.1	mortality factor 4-like protein 1 isoform 1
NM_206839.3	NP_996670.1	mortality factor 4-like protein 1 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	12963728	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in double-strand break repair via homologous recombination	IDA IDA: Inferred from direct assay	20332121	GOA
involved in positive regulation of double-strand break repair via homologous recombination	IDA IDA: Inferred from direct assay	27153538	GOA
involved in regulation of cell cycle	IMP IMP: Inferred from mutant phenotype	27153538	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of NuA4 histone acetyltransferase complex	IDA IDA: Inferred from direct assay	14966270	GOA
part of Sin3-type complex	IDA IDA: Inferred from direct assay	14966270	GOA
part of nucleosome	IDA IDA: Inferred from direct assay	27153538	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MORF4L1 Protein Structure

Tudor-knot

MRG

0
100
200
300
362 a.a.

Protein Preferred Names	Protein Names
mortality factor 4-like protein 1	Esa1p-associated factor 3 homolog

MORF4L1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	MORF4L1	Q9UBU8	FLJ13057	Homo sapiens	Q53SE7	Validated Y2H	25416956
Intra	MORF4L1	Q9UBU8	FAM9B	Homo sapiens	Q8IZU0	Y2H Array	25416956
Intra	MORF4L1	Q9UBU8	FAM9B	Homo sapiens	Q8IZU0	Validated Y2H	25416956
Intra	MORF4L1	Q9UBU8	BEND7	Homo sapiens	Q8N7W2-2	Y2H Array	25416956
Intra	MORF4L1	Q9UBU8	HMBOX1	Homo sapiens	Q6NT76-2	Y2H Array	25416956
Intra	MORF4L1	Q9UBU8	ZBTB10	Homo sapiens	Q96DT7	Y2H Prey Pooling	25416956
Intra	MORF4L1	Q9UBU8	ZBTB10	Homo sapiens	Q96DT7	Y2H Array	25416956
Intra	MORF4L1	Q9UBU8	CAMK2B	Homo sapiens	Q13554	Validated Y2H	25416956
Intra	MORF4L1	Q9UBU8	CAMK2B	Homo sapiens	Q13554	Y2H Prey Pooling	25416956
Intra	MORF4L1	Q9UBU8	HMBOX1	Homo sapiens	Q6NT76	Y2H Array	25416956
Intra	MORF4L1	Q9UBU8	HMBOX1	Homo sapiens	Q6NT76	Validated Y2H	25416956
Intra	MORF4L1	Q9UBU8	MEOX1	Homo sapiens	P50221	Validated Y2H	25416956
Intra	MORF4L1	Q9UBU8	ARRDC3	Homo sapiens	Q96B67	Y2H Prey Pooling	25416956
Intra	MORF4L1	Q9UBU8	ARRDC3	Homo sapiens	Q96B67	Y2H Array	25416956
Intra	MORF4L1	Q9UBU8	TNIP1	Homo sapiens	Q15025	Y2H Array	31515488
Intra	MORF4L1	Q9UBU8	ZBTB9	Homo sapiens	Q96C00	Y2H Array	31515488
Intra	MORF4L1	Q9UBU8	MRGBP	Homo sapiens	Q9NV56	TAP	24981860
Intra	MORF4L1	Q9UBU8	MRGBP	Homo sapiens	Q9NV56	Anti Tag CoIP	33961781
Intra	MORF4L1	Q9UBU8	GOLGA2	Homo sapiens	Q08379	Y2H Prey Pooling	25416956
Intra	MORF4L1	Q9UBU8	GOLGA2	Homo sapiens	Q08379	Y2H Array	25416956
Intra	MORF4L1	Q9UBU8	RACGAP1	Homo sapiens	Q9H0H5	Validated Y2H	25416956
Intra	MORF4L1	Q9UBU8	RACGAP1	Homo sapiens	Q9H0H5	Y2H Array	25416956
Intra	MORF4L1	Q9UBU8	TFCP2	Homo sapiens	Q12800	Y2H Prey Pooling	25416956
Intra	MORF4L1	Q9UBU8	TFCP2	Homo sapiens	Q12800	Y2H Array	25416956
Intra	MORF4L1	Q9UBU8	TFCP2	Homo sapiens	Q12800	Validated Y2H	25416956
Intra	MORF4L1	Q9UBU8	TNNT1	Homo sapiens	P13805	Y2H Prey Pooling	25416956
Intra	MORF4L1	Q9UBU8	TNNT1	Homo sapiens	P13805	Validated Y2H	25416956
Intra	MORF4L1	Q9UBU8	FXR2	Homo sapiens	P51116	Y2H Array	25416956
Intra	MORF4L1	Q9UBU8	FXR2	Homo sapiens	P51116	Y2H Prey Pooling	25416956
Intra	MORF4L1	Q9UBU8	PBXIP1	Homo sapiens	Q96AQ6	Validated Y2H	25416956
Intra	MORF4L1	Q9UBU8	LZTS2	Homo sapiens	Q9BRK4	Validated Y2H	25416956
Intra	MORF4L1	Q9UBU8	LZTS2	Homo sapiens	Q9BRK4	Y2H Array	25416956
Intra	MORF4L1	Q9UBU8	NAV2	Homo sapiens	Q8IVL1	Validated Y2H	25416956
Intra	MORF4L1	Q9UBU8	THAP1	Homo sapiens	Q9NVV9	Validated Y2H	25416956
Intra	MORF4L1	Q9UBU8	IKZF1	Homo sapiens	Q13422	Y2H Prey Pooling	25416956
Intra	MORF4L1	Q9UBU8	MRFAP1L1	Homo sapiens	Q96HT8	Y2H Prey Pooling	25416956
Intra	MORF4L1	Q9UBU8	MRFAP1L1	Homo sapiens	Q96HT8	MAPPIT	25416956
Intra	MORF4L1	Q9UBU8	MRFAP1L1	Homo sapiens	Q96HT8	Validated Y2H	25416956
Intra	MORF4L1	Q9UBU8	MRFAP1L1	Homo sapiens	Q96HT8	Y2H Pooling	16189514
Intra	MORF4L1	Q9UBU8	MRFAP1L1	Homo sapiens	Q96HT8	Anti Tag CoIP	33961781
Intra	MORF4L1	Q9UBU8	MRFAP1L1	Homo sapiens	Q96HT8	TAP	24981860
Intra	MORF4L1	Q9UBU8	MRFAP1	Homo sapiens	Q9Y605	Anti Tag CoIP	33961781
Intra	MORF4L1	Q9UBU8	MRFAP1	Homo sapiens	Q9Y605	Validated Y2H	25416956
Intra	MORF4L1	Q9UBU8	MRFAP1	Homo sapiens	Q9Y605	Y2H Array	25416956
Intra	MORF4L1	Q9UBU8	MRFAP1	Homo sapiens	Q9Y605	Y2H Prey Pooling	25416956
Intra	MORF4L1	Q9UBU8	MRFAP1	Homo sapiens	Q9Y605	TAP	24981860

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Paraneoplastic Cerebellar Degeneration	Pcd Paraneoplastic Cerebellar Ataxia Rapidely Progressive Cerebellar Syndrome Subacute Cerebellar Degeneration
Wolf-Hirschhorn Syndrome	Pitt-Rogers-Danks Syndrome WHS Chromosome 4p16.3 Deletion Syndrome Wittwer Syndrome 4p- Syndrome Pitt Syndrome 4p Deletion Syndrome Distal Deletion 4p Distal Monosomy 4p Telomeric Deletion 4p Prds 4p Syndrome Chromosome 4p Syndrome Microcephaly, Iugr, Hypertelorism, Ptosis, Iris Coloboma, Hooked Nose, External Ear Dysplasia, Psychomotor Retardation Wolf Syndrome Chromosome 4p Deletion Syndrome Chromosome 4p Monosomy Del Syndrome Monosomy 4p Partial Monosomy 4p Chromosome 4 Short Arm Deletion

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08593	MORF4L1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	MORF4L1	VGNC	VGNC:56001
Rattus norvegicus	MORF4L1	RGD	RGD:1307938
Felis catus	MORF4L1	VGNC	VGNC:97512
Mus musculus	MORF4L1	MGD	MGI:1096551
Macaca mulatta	MORF4L1	VGNC	VGNC:84396
Others	MORF4L1	NCBI