MORF4L1 - mortality factor 4 like 1 Gene

Homo sapiens

Also known as Eaf3; MEAF3; MRG15; FWP006; S863-6; HsT17725; MORFRG15

Gene ID: 10933 | Gene type: protein coding

About MORF4L1

Cytogenetic location: 15q25.1 Genomic coordinates (GRCh38): 15:78,872,890-78,898,139 (from NCBI)

This gene has 23 transcripts (splice variants), 280 orthologues and 2 paralogues. Ubiquitous expression in testis (RPKM 192.5), brain (RPKM 119.7) and 25 other tissues.

Summary

Enables protein N-terminus binding activity. Involved in double-strand break repair via homologous recombination and histone modification. Located in nuclear speck. Part of NuA4 Histone Acetyltransferase complex and Sin3 complex. [provided by Alliance of Genome Resources, Apr 2022]

MORF4L1 Products(5)

mRNA	Protein	Name
NM_001265603.2	NP_001252532.1	mortality factor 4-like protein 1 isoform 3
NM_001265604.2	NP_001252533.1	mortality factor 4-like protein 1 isoform 3
NM_001265605.2	NP_001252534.1	mortality factor 4-like protein 1 isoform 3
NM_006791.4	NP_006782.1	mortality factor 4-like protein 1 isoform 1
NM_206839.3	NP_996670.1	mortality factor 4-like protein 1 isoform 2

MORF4L1 Protein Structure

Tudor-knot

MRG

0
100
200
300
362 a.a.

Protein Preferred Names

Protein Names

mortality factor 4-like protein 1

Esa1p-associated factor 3 homolog

Related Diseases

Diseases

Alias

Paraneoplastic Cerebellar Degeneration

Pcd	Paraneoplastic Cerebellar Ataxia
Rapidely Progressive Cerebellar Syndrome	Subacute Cerebellar Degeneration

Wolf-Hirschhorn Syndrome

Pitt-Rogers-Danks Syndrome	WHS
Chromosome 4p16.3 Deletion Syndrome	Wittwer Syndrome
4p- Syndrome	Pitt Syndrome
4p Deletion Syndrome	Distal Deletion 4p
Distal Monosomy 4p	Telomeric Deletion 4p
Prds	4p Syndrome
Chromosome 4p Syndrome	Microcephaly, Iugr, Hypertelorism, Ptosis, Iris Coloboma, Hooked Nose, External Ear Dysplasia, Psychomotor Retardation
Wolf Syndrome	Chromosome 4p Deletion Syndrome
Chromosome 4p Monosomy	Del Syndrome
Monosomy 4p	Partial Monosomy 4p
Chromosome 4 Short Arm Deletion

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08593	MORF4L1 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	MORF4L1	VGNC	VGNC:56001
Rattus norvegicus	MORF4L1	RGD	RGD:1307938
Felis catus	MORF4L1	VGNC	VGNC:97512
Mus musculus	MORF4L1	MGD	MGI:1096551
Macaca mulatta	MORF4L1	VGNC	VGNC:84396

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