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LASP1 - LIM and SH3 protein 1 Gene

Also Known as MLN50; Lasp-1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 3927

About LASP1

Cytogenetic location: 17q12 Genomic coordinates (GRCh38): 17:38,870,058-38,921,770 (from NCBI)

This gene has 9 transcripts (splice variants), 263 orthologues, 4 paralogues and is associated with 52 phenotypes. Ubiquitous expression in small intestine (RPKM 79.0), duodenum (RPKM 59.7) and 25 other tissues.

Summary

This gene encodes a member of a subfamily of LIM proteins, characterized by a LIM motif and a domain of Src homology region 3, and also a member of the nebulin family of actin-binding proteins. The encoded protein is a cAMP and cGMP dependent signaling protein and binds to the actin Cytoskeleton at extensions of the cell membrane. The encoded protein has been linked to metastatic breast Cancer, hematopoetic tumors such as B-cell lymphomas, and colorectal Cancer. [provided by RefSeq, Oct 2012]

LASP1 Products (2)

mRNA	Protein	Name
NM_001271608.2	NP_001258537.1	LIM and SH3 domain protein 1 isoform b
NM_006148.4	NP_006139.1	LIM and SH3 domain protein 1 isoform a

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	25468996	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LASP1 Protein Structure

LIM

Nebulin

SH3_9

0
100
200
261 a.a.

Protein Preferred Names	Protein Names
LIM and SH3 domain protein 1	metastatic lymph node gene 50 protein

LASP1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	LASP1	Q14847	KRTAP4-2	Homo sapiens	Q9BYR5	Y2H Prey Pooling	25416956
Intra	LASP1	Q14847	TJP2	Homo sapiens	Q9UDY2	Far-WB	22665060
Intra	LASP1	Q14847	TJP2	Homo sapiens	Q9UDY2	PLA	22665060
Intra	LASP1	Q14847	TJP2	Homo sapiens	Q9UDY2	Pull Down	22665060
Intra	LASP1	Q14847	REL	Homo sapiens	Q04864	Y2H Prey Pooling	25416956
Intra	LASP1	Q14847	PSMA3	Homo sapiens	P25788	Validated Y2H	25416956
Intra	LASP1	Q14847	TRIP13	Homo sapiens	Q15645	Validated Y2H	25416956
Intra	LASP1	Q14847	TRIP13	Homo sapiens	Q15645	Y2H Pooling	16189514
Intra	LASP1	Q14847	TRIP13	Homo sapiens	Q15645	Y2H	21516116
Intra	LASP1	Q14847	RHOXF2	Homo sapiens	Q9BQY4	Y2H Array	25416956
Intra	LASP1	Q14847	ZBTB9	Homo sapiens	Q96C00	Y2H Array	31515488
Intra	LASP1	Q14847	ZBTB9	Homo sapiens	Q96C00	Validated Y2H	25416956
Intra	LASP1	Q14847	ZBTB9	Homo sapiens	Q96C00	Y2H Array	25416956
Intra	LASP1	Q14847	ZBTB9	Homo sapiens	Q96C00	Y2H Prey Pooling	25416956
Intra	LASP1	Q14847	SH2D2A	Homo sapiens	Q9NP31	Lumier	25814554
Intra	LASP1	Q14847	TCF4	Homo sapiens	P15884	Y2H Array	25416956
Intra	LASP1	Q14847	TCF4	Homo sapiens	P15884	Y2H Prey Pooling	25416956
Intra	LASP1	Q14847	ZC2HC1A	Homo sapiens	Q96GY0	Y2H Array	25416956
Intra	LASP1	Q14847	ZC2HC1A	Homo sapiens	Q96GY0	Validated Y2H	25416956
Intra	LASP1	Q14847	GOLGA2	Homo sapiens	Q08379	Y2H Prey Pooling	25416956
Intra	LASP1	Q14847	TRIM27	Homo sapiens	P14373	Validated Y2H	25416956
Intra	LASP1	Q14847	MDFI	Homo sapiens	Q99750	Y2H Array	19060904
Intra	LASP1	Q14847	MDFI	Homo sapiens	Q99750	Y2H Pooling	19060904
Intra	LASP1	Q14847	SEPTIN3	Homo sapiens	Q9UH03	Y2H Prey Pooling	25416956
Intra	LASP1	Q14847	ARHGEF15	Homo sapiens	O94989	Validated Y2H	25416956
Intra	LASP1	Q14847	ARHGEF15	Homo sapiens	O94989	Y2H Array	25416956
Intra	LASP1	Q14847	ARHGEF15	Homo sapiens	O94989	Y2H Prey Pooling	25416956
Intra	LASP1	Q14847	LZTS2	Homo sapiens	Q9BRK4	Validated Y2H	25416956
Intra	LASP1	Q14847	THAP1	Homo sapiens	Q9NVV9	Y2H Array	25416956
Intra	LASP1	Q14847	SPRY2	Homo sapiens	O43597	Y2H Prey Pooling	25416956
Intra	LASP1	Q14847	SPRY2	Homo sapiens	O43597	Validated Y2H	25416956
Intra	LASP1	Q14847	SPRY2	Homo sapiens	O43597	Y2H Array	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

LASP1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P89783	LASP-1 Antibody (YA9127)	WB, IP, ELISA	human

Related Diseases

Diseases	Alias
Breast Cancer	Breast Carcinoma Male Breast Cancer Breast Cancer, Familial Malignant Neoplasm Of Breast Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Medulloblastoma	MDB Cpnet Localized Primitive Neuroectodermal Tumor Classic Medulloblastoma Medulloblastoma Predisposition Syndrome Medulloblastoma, Somatic Brain Medulloblastoma Cns Pnet Infratentorial Primitive Neuroectodermal Tumor Neuroectodermal Tumors, Primitive Medulloblastomas Desmoplastic Medulloblastoma Medulloblastoma, With Extensive Nodularity Medulloblastoma Of Unspecified Site Medullomyoblastoma Of Unspecified Site

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P11596	NOTA-Asp2-αvβ6L		/	Unkown
HY-RS07535	LASP1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22606	Lasp1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS29121	Lasp1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	LASP1	MGD	MGI:109656
Rattus norvegicus	LASP1	RGD	RGD:68408
Macaca mulatta	LASP1	VGNC	VGNC:74237
Bos taurus	LASP1	VGNC	VGNC:30798
Felis catus	LASP1	VGNC	VGNC:99182
Canis familiaris	LASP1	VGNC	VGNC:42595
Others	LASP1	NCBI