ARHGEF15 - Rho guanine nucleotide exchange factor 15 Gene

Also Known as E5; ARGEF15; Ephexin5; Vsm-RhoGEF

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 22899

About ARHGEF15

Cytogenetic location: 17p13.1 Genomic coordinates (GRCh38): 17:8,310,241-8,322,511 (from NCBI)

This gene has 9 transcripts (splice variants), 213 orthologues and 6 paralogues. Broad expression in fat (RPKM 15.9), lung (RPKM 13.8) and 19 other tissues.

Summary

Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein-coupled receptors. This gene encodes a protein that functions as a specific guanine nucleotide exchange factor for RhoA. It also interacts with ephrin A4 in vascular smooth muscle cells. Two alternatively spliced transcripts variants that encode the same protein have been found for this gene. [provided by RefSeq, Aug 2010]

ARHGEF15 Products (2)

mRNA	Protein	Name
NM_025014.2	NP_079290.1	rho guanine nucleotide exchange factor 15
NM_173728.4	NP_776089.2	rho guanine nucleotide exchange factor 15

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables guanyl-nucleotide exchange factor activity	IDA IDA: Inferred from direct assay	12775584	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	12775584	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in regulation of catalytic activity	IDA IDA: Inferred from direct assay	12775584	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ARHGEF15 Protein Structure

RhoGEF

0
200
400
600
800
841 a.a.

Protein Preferred Names	Protein Names
rho guanine nucleotide exchange factor 15	Rho guanine nucleotide exchange factor (GEF) 15

ARHGEF15 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	ARHGEF15	O94989	PRKG1	Homo sapiens	Q13976-2	Validated Y2H	32296183
Intra	ARHGEF15	O94989	PIN1	Homo sapiens	Q13526	Y2H Array	25416956
Intra	ARHGEF15	O94989	PIN1	Homo sapiens	Q13526	Y2H Prey Pooling	25416956
Intra	ARHGEF15	O94989	GORASP2	Homo sapiens	Q9H8Y8	Y2H Array	32296183
Intra	ARHGEF15	O94989	GORASP2	Homo sapiens	Q9H8Y8	Validated Y2H	32296183
Intra	ARHGEF15	O94989	GORASP2	Homo sapiens	Q9H8Y8	Y2H Prey Pooling	32296183
Intra	ARHGEF15	O94989	CEP55	Homo sapiens	Q53EZ4	Y2H Array	26871637
Intra	ARHGEF15	O94989	CEP55	Homo sapiens	Q53EZ4	Y2H Array	32296183
Intra	ARHGEF15	O94989	CEP55	Homo sapiens	Q53EZ4	Validated Y2H	26871637
Intra	ARHGEF15	O94989	CEP55	Homo sapiens	Q53EZ4	Validated Y2H	32296183
Intra	ARHGEF15	O94989	CEP55	Homo sapiens	Q53EZ4	Y2H Prey Pooling	25416956
Intra	ARHGEF15	O94989	CEP55	Homo sapiens	Q53EZ4	Y2H Prey Pooling	26871637
Intra	ARHGEF15	O94989	CEP55	Homo sapiens	Q53EZ4	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Developmental And Epileptic Encephalopathy	Encephalopathy, Developmental And Epileptic
Ohtahara Syndrome
Spastic Ataxia, Charlevoix-Saguenay Type	Charlevoix-Saguenay Spastic Ataxia Autosomal Recessive Spastic Ataxia Of Charlevoix-Saguenay Arsacs SACS Spax6 Spastic Ataxia Charlevoix-Saguenay Type Spastic Ataxia 6, Autosomal Recessive Autosomal Recessive Spastic Ataxia Type 6 Spastic Ataxia Of Charlevoix-Saguenay Atx/Hsp-Sacs Ataxia, Spastic, Charlevoix-Saguenay Type
Early Infantile Epileptic Encephalopathy	Early Infantile Epileptic Encephalopathy With Burst-Suppression Early Infantile Epileptic Encephalopathy With Suppression Bursts Eiee Early Infantile Epileptic Encephalopathy With Suppression-Bursts Ohtahara Syndrome Encephalopathy, Epileptic, Early Infantile
Hypophosphatasia, Childhood	Childhood Hypophosphatasia Childhood-Onset Hypophosphatasia HPPC Childhood-Onset Phosphoethanolaminuria Childhood-Onset Rathburn Disease Childhood-Onset Rathbun Disease

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00950	ARHGEF15 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	ARHGEF15	VGNC	VGNC:38076
Macaca mulatta	ARHGEF15	VGNC	VGNC:69832
Rattus norvegicus	ARHGEF15	RGD	RGD:1306961
Bos taurus	ARHGEF15	VGNC	VGNC:26107
Mus musculus	ARHGEF15	MGD	MGI:3045246
Felis catus	ARHGEF15	VGNC	VGNC:59900
Others	ARHGEF15	NCBI