2. Gene
  3. ARHGEF15 - Rho guanine nucleotide exchange factor 15 Gene

ARHGEF15 - Rho guanine nucleotide exchange factor 15 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as E5; ARGEF15; Ephexin5; Vsm-RhoGEF

Gene ID: 22899 | Gene type: protein coding

About ARHGEF15

Cytogenetic location: 17p13.1 Genomic coordinates (GRCh38): 17:8,310,241-8,322,511 (from NCBI)

This gene has 9 transcripts (splice variants), 213 orthologues and 6 paralogues. Broad expression in fat (RPKM 15.9), lung (RPKM 13.8) and 19 other tissues.

Summary

Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein-coupled receptors. This gene encodes a protein that functions as a specific guanine nucleotide exchange factor for RhoA. It also interacts with ephrin A4 in vascular smooth muscle cells. Two alternatively spliced transcripts variants that encode the same protein have been found for this gene. [provided by RefSeq, Aug 2010]

ARHGEF15 Products(2)

mRNA Protein Name
NM_025014.2 NP_079290.1 rho guanine nucleotide exchange factor 15
NM_173728.4 NP_776089.2 rho guanine nucleotide exchange factor 15

ARHGEF15 Protein Structure

RhoGEF

RhoGEF: RhoGEF domain (422 - 598)

  • 0
  • 200
  • 400
  • 600
  • 841 a.a.
Protein Preferred Names Protein Names

rho guanine nucleotide exchange factor 15

Rho guanine nucleotide exchange factor (GEF) 15

Related Diseases

Diseases Alias
Developmental And Epileptic Encephalopathy

Encephalopathy, Developmental And Epileptic
Ohtahara Syndrome
Spastic Ataxia, Charlevoix-Saguenay Type

Charlevoix-Saguenay Spastic Ataxia

Autosomal Recessive Spastic Ataxia Of Charlevoix-Saguenay

Arsacs

SACS

Spax6

Spastic Ataxia Charlevoix-Saguenay Type

Spastic Ataxia 6, Autosomal Recessive

Autosomal Recessive Spastic Ataxia Type 6

Spastic Ataxia Of Charlevoix-Saguenay

Atx/Hsp-Sacs

Ataxia, Spastic, Charlevoix-Saguenay Type
Early Infantile Epileptic Encephalopathy

Early Infantile Epileptic Encephalopathy With Burst-Suppression

Early Infantile Epileptic Encephalopathy With Suppression Bursts

Eiee

Early Infantile Epileptic Encephalopathy With Suppression-Bursts

Ohtahara Syndrome

Encephalopathy, Epileptic, Early Infantile
Hypophosphatasia, Childhood

Childhood Hypophosphatasia

Childhood-Onset Hypophosphatasia

HPPC

Childhood-Onset Phosphoethanolaminuria

Childhood-Onset Rathburn Disease

Childhood-Onset Rathbun Disease
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS00950 ARHGEF15 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris ARHGEF15 VGNC VGNC:38076
Macaca mulatta ARHGEF15 VGNC VGNC:69832
Rattus norvegicus ARHGEF15 RGD RGD:1306961
Bos taurus ARHGEF15 VGNC VGNC:26107
Mus musculus ARHGEF15 MGD MGI:3045246
Felis catus ARHGEF15 VGNC VGNC:59900