PRAM1 - PML-RARA regulated adaptor molecule 1 Gene

Also Known as PRAM-1; PML-RAR

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 84106

About PRAM1

Cytogenetic location: 19p13.2 Genomic coordinates (GRCh38): 19:8,490,056-8,502,640 (from NCBI)

This gene has 4 transcripts (splice variants), 145 orthologues and 2 paralogues. Biased expression in bone marrow (RPKM 29.0), appendix (RPKM 3.8) and 2 other tissues.

Summary

The protein encoded by this gene is similar to Fyn binding protein (FYB/SLAP-130), an adaptor protein involved in T cell receptor mediated signaling. This gene is expressed and regulated during normal myelopoiesis. The expression of this gene is induced by retinoic acid and is inhibited by the expression of PML-RARalpha, a fusion protein of promyelocytic leukemia (PML) and the retinoic acid receptor-alpha (RARalpha). [provided by RefSeq, Jul 2008]

PRAM1 Products (1)

mRNA Protein Name
NM_032152.5 NP_115528.4 PML-RARA-regulated adapter molecule 1

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
21163940 GOA
enables protein kinase binding IPI
IPI: Inferred from physical interaction
20873783 GOA
Cellular Component GO Annotation Evidence References Source
part of protein-containing complex IDA
IDA: Inferred from direct assay
20873783 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PRAM1 Protein Structure

hSH3

hSH3: Helically-extended SH3 domain (576 - 655)

  • 0
  • 200
  • 400
  • 600
  • 670 a.a.
Protein Preferred Names Protein Names

PML-RARA-regulated adapter molecule 1

  • PML-RARA target gene encoding an Adaptor Molecule-1

PRAM1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
PRAM1 Q96QH2 KRT40 Homo sapiens Q6A162
Validated Y2H
25416956
Intra
PRAM1 Q96QH2 KRT40 Homo sapiens Q6A162
Y2H Array
25416956
Intra
PRAM1 Q96QH2 NEK7 Homo sapiens Q8TDX7
Validated Y2H
32814053
Intra
PRAM1 Q96QH2 NEK7 Homo sapiens Q8TDX7
Y2H Array
32814053
Intra
PRAM1 Q96QH2 NEK7 Homo sapiens Q8TDX7
Y2H Pooling
32814053
Intra
PRAM1 Q96QH2 CCDC57 Homo sapiens Q2TAC2-2
Y2H Prey Pooling
32296183
Intra
PRAM1 Q96QH2 CCDC57 Homo sapiens Q2TAC2-2
Y2H Array
32296183
Intra
PRAM1 Q96QH2 FXR1 Homo sapiens P51114-2
Y2H Prey Pooling
32296183
Intra
PRAM1 Q96QH2 FXR1 Homo sapiens P51114-2
Y2H Array
32296183
Intra
PRAM1 Q96QH2 NEDD9 Homo sapiens Q14511-2
Y2H Array
32296183
Intra
PRAM1 Q96QH2 NEDD9 Homo sapiens Q14511-2
Y2H Prey Pooling
32296183
Intra
PRAM1 Q96QH2 TP53BP2 Homo sapiens Q05BL1
Y2H Array
32296183
Intra
PRAM1 Q96QH2 TP53BP2 Homo sapiens Q05BL1
Y2H Prey Pooling
32296183
Intra
PRAM1 Q96QH2 SKAP1 Homo sapiens Q86WV1-2
Y2H Prey Pooling
32296183
Intra
PRAM1 Q96QH2 SKAP1 Homo sapiens Q86WV1-2
Y2H Array
32296183
Intra
PRAM1 Q96QH2 SKAP1 Homo sapiens Q86WV1
Y2H Array
31515488
Intra
PRAM1 Q96QH2 GOLGA2 Homo sapiens Q08379
Y2H Prey Pooling
32296183
Intra
PRAM1 Q96QH2 GOLGA2 Homo sapiens Q08379
Y2H Array
32296183
Intra
PRAM1 Q96QH2 BCAR1 Homo sapiens P56945
Y2H Prey Pooling
32296183
Intra
PRAM1 Q96QH2 BCAR1 Homo sapiens P56945
Y2H Array
32296183
Intra
PRAM1 Q96QH2 TRIM27 Homo sapiens P14373
Validated Y2H
25416956
Intra
PRAM1 Q96QH2 TRIM27 Homo sapiens P14373
Y2H Array
25416956
Intra
PRAM1 Q96QH2 RNF32 Homo sapiens Q9H0A6
Y2H Array
21163940
Intra
PRAM1 Q96QH2 RNF32 Homo sapiens Q9H0A6
Pull Down
21163940
Intra
PRAM1 Q96QH2 CDH1 Homo sapiens P12830
Validated Y2H
32814053
Intra
PRAM1 Q96QH2 CDH1 Homo sapiens P12830
Y2H Array
32814053
Intra
PRAM1 Q96QH2 CDH1 Homo sapiens P12830
Y2H Pooling
32814053
Intra
PRAM1 Q96QH2 FXR2 Homo sapiens P51116
Y2H Prey Pooling
32296183
Intra
PRAM1 Q96QH2 FXR2 Homo sapiens P51116
Y2H Array
25416956
Intra
PRAM1 Q96QH2 FXR2 Homo sapiens P51116
Y2H Array
32296183
Intra
PRAM1 Q96QH2 FXR2 Homo sapiens P51116
Y2H Array
31515488
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Acute Promyelocytic Leukemia

  • Leukemia, Acute Promyelocytic

  • Acute Myeloblastic Leukemia Type 3

  • Aml M3

  • APL

  • Leukemia, Acute Promyelocytic, Somatic

  • Aml With T(15

  • 17)(Q22

  • Q12)

  • (Pml/Raralpha) And Variants

  • Apml

  • Acute Myeloblastic Leukemia 3

  • Acute Myeloid Leukemia With T(15

  • 17)(Q22

  • Q12)

  • (Pml/Raralpha) And Variants

  • Acute Myeloblastic Leukaemia Type 3

  • Acute Myeloid Leukaemia M3

  • Acute Myeloid Leukemia M3

  • Acute Promyelocytic Leukaemia

  • M3 Anll

  • Myeloid Leukemia, Acute, M3

  • Leukemia Promyelocytic Acute

  • Leukemia, Promyelocytic, Acute

  • Leukemia, Acute, Promyelocytic
Leukemia

  • Leukemias

  • Leukaemia, Unspecified, Without Mention Of Remission

  • Aleukemic Leukaemia

  • Chronic Leukaemia

  • Subacute Leukaemia

  • Leukaemia Disorder

  • Leukaemia Nos
Leukemia, Acute Myeloid

  • Acute Myeloid Leukemia

  • Leukemia, Acute Myelogenous

  • Acute Myelogenous Leukemia

  • AML

  • Leukemia, Acute Myeloid, Susceptibility To

  • Acute Myeloblastic Leukemia

  • Leukemia, Acute Myeloid, Reduced Survival In, Somatic

  • Acute Myeloid Leukaemia

  • Leukemia, Myelocytic, Acute

  • Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome

  • Secondary Aml

  • Acute Myelocytic Leukemia

  • Acute Myeloid Leukemia, Somatic

  • Leukemia, Acute Myeloid, Somatic

  • Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic

  • Acute Myeloblastic Leukaemia

  • Acute Myelogenous Leukaemia

  • Aml - Acute Myeloid Leukemia

  • Acute Myeloid Leukemia With Cebpa Somatic Mutations

  • Aml With Cebpa Somatic Mutations

  • Inherited Acute Myeloid Leukemia

  • Familial Aml

  • Inherited Aml

  • Pure Familial Aml

  • Pure Familial Acute Myeloid Leukemia

  • Secondary Acute Myeloid Leukemia

  • Therapy-Related Aml And Myelodysplastic Syndrome

  • Acute Myeloid Leukemia, Secondary

  • Acute Non-Lymphoblastic Leukemia

  • Acute Non-Lymphocytic Leukemia

  • Acute Biphenotypic Leukemia

  • Acute Undifferentiated Leukemia

  • Acute Myeloblastic Leukaemia With Multilineage Dysplasia

  • Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission

  • Acute Myeloid Leukaemia With Myelodysplasia-Related Features
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS11048 PRAM1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus PRAM1 MGD MGI:3576625
Canis familiaris PRAM1 VGNC VGNC:44940
Bos taurus PRAM1 VGNC VGNC:33284
Rattus norvegicus PRAM1 RGD RGD:1564330
Macaca mulatta PRAM1 VGNC VGNC:76344
Others PRAM1 NCBI