UBAP2L - ubiquitin associated protein 2 like Gene

Also Known as NICE4; NICE-4

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 9898

About UBAP2L

Cytogenetic location: 1q21.3 Genomic coordinates (GRCh38): 1:154,220,172-154,271,510 (from NCBI)

This gene has 20 transcripts (splice variants), 212 orthologues and 1 paralogue. Ubiquitous expression in testis (RPKM 26.7), placenta (RPKM 21.3) and 25 other tissues.

Summary

Enables RNA binding activity. Involved in binding activity of sperm to zona pellucida and stress granule assembly. Acts upstream of or within hematopoietic stem cell homeostasis. Part of PcG protein complex. [provided by Alliance of Genome Resources, Apr 2022]

UBAP2L Products (24)

mRNA Protein Name
NM_001127320.3 NP_001120792.1 ubiquitin-associated protein 2-like isoform b
NM_001287815.1 NP_001274744.1 ubiquitin-associated protein 2-like isoform c
NM_001287816.1 NP_001274745.1 ubiquitin-associated protein 2-like isoform d
NM_001330730.1 NP_001317659.1 ubiquitin-associated protein 2-like isoform e
NM_001375612.1 NP_001362541.1 ubiquitin-associated protein 2-like isoform f
NM_001375614.1 NP_001362543.1 ubiquitin-associated protein 2-like isoform g
NM_001375615.1 NP_001362544.1 ubiquitin-associated protein 2-like isoform h
NM_001375616.1 NP_001362545.1 ubiquitin-associated protein 2-like isoform h
NM_001375617.1 NP_001362546.1 ubiquitin-associated protein 2-like isoform i
NM_001375618.1 NP_001362547.1 ubiquitin-associated protein 2-like isoform a
NM_001375619.1 NP_001362548.1 ubiquitin-associated protein 2-like isoform a
NM_001375620.1 NP_001362549.1 ubiquitin-associated protein 2-like isoform j
NM_001375621.1 NP_001362550.1 ubiquitin-associated protein 2-like isoform j
NM_001375622.1 NP_001362551.1 ubiquitin-associated protein 2-like isoform j
NM_001375623.1 NP_001362552.1 ubiquitin-associated protein 2-like isoform k
NM_001375624.1 NP_001362553.1 ubiquitin-associated protein 2-like isoform l
NM_001375625.1 NP_001362554.1 ubiquitin-associated protein 2-like isoform e
NM_001375626.1 NP_001362555.1 ubiquitin-associated protein 2-like isoform m
NM_001375627.1 NP_001362556.1 ubiquitin-associated protein 2-like isoform m
NM_001375628.1 NP_001362557.1 ubiquitin-associated protein 2-like isoform n
NM_001375629.1 NP_001362558.1 ubiquitin-associated protein 2-like isoform b
NM_001375630.1 NP_001362559.1 ubiquitin-associated protein 2-like isoform b
NM_001375631.1 NP_001362560.1 ubiquitin-associated protein 2-like isoform b
NM_014847.4 NP_055662.3 ubiquitin-associated protein 2-like isoform a

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
19945174 GOA
Biological Process GO Annotation Evidence References Source
involved in binding of sperm to zona pellucida IMP
IMP: Inferred from mutant phenotype
19945174 GOA
acts upstream of or within hematopoietic stem cell homeostasis IGI
IGI: Inferred from genetic interaction
25185265 GOA
involved in positive regulation of stress granule assembly IDA
IDA: Inferred from direct assay
32302570 GOA
involved in stress granule assembly IMP
IMP: Inferred from mutant phenotype
29395067 GOA
Cellular Component GO Annotation Evidence References Source
part of PcG protein complex IDA
IDA: Inferred from direct assay
25185265 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

UBAP2L Protein Structure

DUF3697

DUF3697: Ubiquitin-associated protein 2 (495 - 526)

  • 0
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  • 1000
  • 1087 a.a.
Protein Preferred Names Protein Names

ubiquitin-associated protein 2-like

  • protein NICE-4

UBAP2L Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
UBAP2L Q14157 FXR1 Homo sapiens P51114-2
Y2H Array
32296183
Intra
UBAP2L Q14157 FXR1 Homo sapiens P51114-2
Y2H Prey Pooling
32296183
Cross
UBAP2L Q14157 P0DTD1-PRO_0000449629 SARS-CoV-2 P0DTD1-PRO_0000449629
Y2H Array
36217030
Intra
UBAP2L Q14157 FXR2 Homo sapiens P51116
Y2H Prey Pooling
32296183
Intra
UBAP2L Q14157 FXR2 Homo sapiens P51116
Y2H Array
32296183
Intra
UBAP2L Q14157 FXR2 Homo sapiens P51116
TAP
24981860
Cross: Cross-species interaction Intra: Intraspecies interaction

UBAP2L Antibodies

Cat. No. Product Name Application Reactivity
HY-P810964 NICE4 Antibody WB, ICC/IF Human, Mouse, Rat

Related Diseases

Diseases Alias
Spinal Cord Neuroblastoma

  • Neuroblastoma Of The Spinal Cord
Spinal Cord Primitive Neuroectodermal Neoplasm

  • Spinal Cord Pnet

  • Spinal Cord Primitive Neuroectodermal Tumor
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS15330 UBAP2L Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus UBAP2L VGNC VGNC:36573
Mus musculus UBAP2L MGD MGI:1921633
Rattus norvegicus UBAP2L RGD RGD:1308707
Macaca mulatta UBAP2L VGNC VGNC:79825
Canis familiaris UBAP2L VGNC VGNC:48047
Felis catus UBAP2L VGNC VGNC:66754
Others UBAP2L NCBI