2. Gene
  3. UCHL5 - ubiquitin C-terminal hydrolase L5 Gene

UCHL5 - ubiquitin C-terminal hydrolase L5 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as UCH37; CGI-70; INO80R; UCH-L5

Gene ID: 51377 | Gene type: protein coding

About UCHL5

Cytogenetic location: 1q31.2 Genomic coordinates (GRCh38): 1:193,012,254-193,060,076 (from NCBI)

This gene has 13 transcripts (splice variants), 213 orthologues and 3 paralogues. Ubiquitous expression in brain (RPKM 5.2), esophagus (RPKM 3.6) and 25 other tissues.

Summary

Enables endopeptidase inhibitor activity; Proteasome binding activity; and thiol-dependent Deubiquitinase. Involved in negative regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of smoothened signaling pathway; and protein deubiquitination. Located in cytosol; nucleolus; and nucleoplasm. Colocalizes with Ino80 complex. [provided by Alliance of Genome Resources, Apr 2022]

UCHL5 Products(17)

mRNA Protein Name
NM_001199261.3 NP_001186190.1 ubiquitin carboxyl-terminal hydrolase isozyme L5 isoform 2
NM_001199262.3 NP_001186191.1 ubiquitin carboxyl-terminal hydrolase isozyme L5 isoform 3
NM_001199263.3 NP_001186192.1 ubiquitin carboxyl-terminal hydrolase isozyme L5 isoform 4
NM_001350840.2 NP_001337769.1 ubiquitin carboxyl-terminal hydrolase isozyme L5 isoform 5
NM_001350841.2 NP_001337770.1 ubiquitin carboxyl-terminal hydrolase isozyme L5 isoform 6
NM_001350842.2 NP_001337771.1 ubiquitin carboxyl-terminal hydrolase isozyme L5 isoform 7
NM_001350843.2 NP_001337772.1 ubiquitin carboxyl-terminal hydrolase isozyme L5 isoform 8
NM_001350844.2 NP_001337773.1 ubiquitin carboxyl-terminal hydrolase isozyme L5 isoform 9
NM_001350845.2 NP_001337774.1 ubiquitin carboxyl-terminal hydrolase isozyme L5 isoform 10
NM_001350846.2 NP_001337775.1 ubiquitin carboxyl-terminal hydrolase isozyme L5 isoform 11
NM_001350847.2 NP_001337776.1 ubiquitin carboxyl-terminal hydrolase isozyme L5 isoform 12
NM_001350848.2 NP_001337777.1 ubiquitin carboxyl-terminal hydrolase isozyme L5 isoform 13
NM_001350849.2 NP_001337778.1 ubiquitin carboxyl-terminal hydrolase isozyme L5 isoform 13
NM_001350850.2 NP_001337779.1 ubiquitin carboxyl-terminal hydrolase isozyme L5 isoform 14
NM_001350851.2 NP_001337780.1 ubiquitin carboxyl-terminal hydrolase isozyme L5 isoform 14
NM_001350852.2 NP_001337781.1 ubiquitin carboxyl-terminal hydrolase isozyme L5 isoform 15
NM_015984.5 NP_057068.1 ubiquitin carboxyl-terminal hydrolase isozyme L5 isoform 1

UCHL5 Protein Structure

Peptidase_C12

Peptidase_C12: Ubiquitin carboxyl-terminal hydrolase, family 1 (7 - 211)

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  • 329 a.a.
Protein Preferred Names Protein Names

ubiquitin carboxyl-terminal hydrolase isozyme L5

INO80 complex subunit R

Related Diseases

Diseases Alias
Machado-Joseph Disease

SCA3

MJD

Spinocerebellar Ataxia 3

Azorean Disease

Spinocerebellar Ataxia Type 3

Spinocerebellar Atrophy

Azorean Neurologic Disease

Spinopontine Atrophy

Nigrospinodentatal Degeneration

Spinocerebellar Atrophy Iii

Spinocerebellar Atrophy Type 3

Azorean Ataxia

Azorean Disease Of The Nervous System

Machado Disease

Nigro-Spino-Dentatal Degeneration With Nuclear Ophthalmoplegia

Disease, Machado-Joseph

Ataxia, Spinocerebellar
Autosomal Dominant Cerebellar Ataxia

Spinocerebellar Ataxia

Adca

Pierre Marie Cerebellar Ataxia

Ataxia, Spinocerebellar

Sca

Autosomal Dominant Spinocerebellar Ataxia

Spinocerebellar Ataxias
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (5)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-13989 b-AP15 98.57% Unkown
HY-149228 USP28-IN-2 Inhibitor / Unkown
HY-149229 USP28-IN-3 Inhibitor / Unkown
HY-149230 USP28-IN-4 Inhibitor / Unkown
HY-RS15402 UCHL5 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus UCHL5 VGNC VGNC:97678
Canis familiaris UCHL5 VGNC VGNC:48105
Mus musculus UCHL5 MGD MGI:1914848
Bos taurus UCHL5 VGNC VGNC:36633
Rattus norvegicus UCHL5 RGD RGD:1305414
Macaca mulatta UCHL5 VGNC VGNC:79197
Others UCHL5 NCBI