ACTR8 - actin related protein 8 Gene

Also Known as ARP8; hArp8; INO80N

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 93973

About ACTR8

Cytogenetic location: 3p21.1 Genomic coordinates (GRCh38): 3:53,858,992-53,882,152 (from NCBI)

This gene has 6 transcripts (splice variants), 197 orthologues and 26 paralogues. Ubiquitous expression in testis (RPKM 6.6), kidney (RPKM 6.1) and 25 other tissues.

Summary

Predicted to enable ATP binding activity. Predicted to be involved in chromatin remodeling; double-strand break repair; and regulation of transcription, DNA-templated. Located in centrosome and nucleoplasm. Part of Ino80 complex. [provided by Alliance of Genome Resources, Apr 2022]

ACTR8 Products (2)

mRNA Protein Name
NM_001410774.1 NP_001397703.1 actin-related protein 8 isoform 2
NM_022899.5 NP_075050.3 actin-related protein 8 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
16230350 GOA
Biological Process GO Annotation Evidence References Source
involved in chromatin remodeling IDA
IDA: Inferred from direct assay
21303910 GOA
involved in positive regulation of DNA-templated transcription IMP
IMP: Inferred from mutant phenotype
27641337 GOA
involved in regulation of DNA replication IMP
IMP: Inferred from mutant phenotype
25016522 GOA
involved in regulation of DNA strand elongation IMP
IMP: Inferred from mutant phenotype
25016522 GOA
involved in regulation of cell cycle IMP
IMP: Inferred from mutant phenotype
26340092 GOA
involved in regulation of chromosome organization IMP
IMP: Inferred from mutant phenotype
26340092 GOA
Cellular Component GO Annotation Evidence References Source
part of Ino80 complex IDA
IDA: Inferred from direct assay
18026119 GOA
located in nucleus IDA
IDA: Inferred from direct assay
18026119 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ACTR8 Protein Structure

Actin

Actin: Actin (48 - 619)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 624 a.a.
Protein Preferred Names Protein Names

actin-related protein 8

  • ARP8 actin related protein 8 homolog

ACTR8 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
ACTR8 Q9H981 UCHL5 Homo sapiens Q9Y5K5
Anti Tag CoIP
18922472
Intra
ACTR8 Q9H981 ACTR5 Homo sapiens Q9H9F9
Anti Bait CoIP
16230350
Intra
ACTR8 Q9H981 ACTR5 Homo sapiens Q9H9F9
Anti Bait CoIP
18163988
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS00235 ACTR8 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18158 Actr8 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24632 Actr8 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta ACTR8 VGNC VGNC:69406
Rattus norvegicus ACTR8 RGD RGD:1311878
Bos taurus ACTR8 VGNC VGNC:25589
Mus musculus ACTR8 MGD MGI:1860775
Felis catus ACTR8 VGNC VGNC:59560
Canis familiaris ACTR8 VGNC VGNC:37557
Others ACTR8 NCBI