2. Cell Cycle/DNA Damage
  3. Deubiquitinase
  4. 8RK64

8RK64 is a covalent UCHL1 inhibitor (IC50: 0.32 μM). 8RK64 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.

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8RK64 Chemical Structure

8RK64 Chemical Structure

CAS No. : 2705841-52-5

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5 mg USD 560 In-stock
10 mg USD 900 In-stock
25 mg USD 1800 In-stock
50 mg USD 2880 In-stock
100 mg USD 4615 In-stock
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Based on 1 publication(s) in Google Scholar

8RK64 Related Antibodies

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Description

8RK64 is a covalent UCHL1 inhibitor (IC50: 0.32 μM)[1]. 8RK64 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.

IC50 & Target

IC50: 0.32 μM (UCHL1), 216 µM (UCHL3)[1]
Molecular Weight

360.39

Formula

C14H16N8O2S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

N#CN1CC[C@@H](C1)C(NC2=NC3=C(S2)CN(CC3)C(CN=[N+]=[N-])=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (277.48 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7748 mL 13.8739 mL 27.7477 mL
5 mM 0.5550 mL 2.7748 mL 5.5495 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.7748 mL 13.8739 mL 27.7477 mL 69.3693 mL
5 mM 0.5550 mL 2.7748 mL 5.5495 mL 13.8739 mL
10 mM 0.2775 mL 1.3874 mL 2.7748 mL 6.9369 mL
15 mM 0.1850 mL 0.9249 mL 1.8498 mL 4.6246 mL
20 mM 0.1387 mL 0.6937 mL 1.3874 mL 3.4685 mL
25 mM 0.1110 mL 0.5550 mL 1.1099 mL 2.7748 mL
30 mM 0.0925 mL 0.4625 mL 0.9249 mL 2.3123 mL
40 mM 0.0694 mL 0.3468 mL 0.6937 mL 1.7342 mL
50 mM 0.0555 mL 0.2775 mL 0.5550 mL 1.3874 mL
60 mM 0.0462 mL 0.2312 mL 0.4625 mL 1.1562 mL
80 mM 0.0347 mL 0.1734 mL 0.3468 mL 0.8671 mL
100 mM 0.0277 mL 0.1387 mL 0.2775 mL 0.6937 mL
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8RK64 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

8RK642705841-52-5DeubiquitinaseDUBsHEK293TDUB profilingInhibitorinhibitorinhibit

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