2705841-52-5
Chemical Structure
8RK64
- CAS No.: 2705841-52-5
- Formula:C14H16N8O2S
- Molecular Weight:360.39
IUPAC Name: (R)-2-(2,6-dioxopiperidin-3-yl)-4-fluoroisoindoline-1,3-dione
InChIKey: KIWKRCCIHSGWQS-VIFPVBQESA-N
SMILES: N#CN1CC[C@@H](C1)C(NC2=NC3=C(S2)CN(CC3)C(CN=[N+]=[N-])=O)=O
Biological Activity: 8RK64 is a UCHL1 inhibitor that covalently binds the active-site cysteine residue to form an isothiourea adduct, with selectivity over UCHL3, UCHL5, and other cysteine DUBs. 8RK64 inhibits human UCHL1 with an IC50 of 0.32 μM. 8RK64 is an azide-containing precursor usable as a two-step activity-based probe via click chemistry. 8RK64 can be used for the research of Parkinson's disease[1].
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8RK64 | 99.50% | 8RK64 is a UCHL1 inhibitor that covalently binds the active-site cysteine residue to form an isothiourea adduct, with selectivity over UCHL3, UCHL5, and other cysteine DUBs. 8RK64 inhibits human UCHL1 with an IC50 of 0.32 μM. 8RK64 is an azide-containing precursor usable as a two-step activity-based probe via click chemistry. 8RK64 can be used for the research of Parkinson's disease. | ||||||||||||||||||||
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