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PSMA6 - proteasome 20S subunit alpha 6 Gene

Also Known as IOTA; p27K; PROS27

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 5687

About PSMA6

Cytogenetic location: 14q13.2 Genomic coordinates (GRCh38): 14:35,278,558-35,317,493 (from NCBI)

This gene has 17 transcripts (splice variants), 272 orthologues, 18 paralogues and is associated with 1 phenotype. Ubiquitous expression in testis (RPKM 34.7), colon (RPKM 23.0) and 25 other tissues.

Summary

The Proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified Proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the peptidase T1A family, that is a 20S core alpha subunit. Multiple transcript variants encoding several different isoforms have been found for this gene. A pseudogene has been identified on the Y chromosome. [provided by RefSeq, Aug 2013]

PSMA6 Products (4)

mRNA	Protein	Name
NM_001282232.1	NP_001269161.1	proteasome subunit alpha type-6 isoform b
NM_001282233.1	NP_001269162.1	proteasome subunit alpha type-6 isoform b
NM_001282234.1	NP_001269163.1	proteasome subunit alpha type-6 isoform c
NM_002791.3	NP_002782.1	proteasome subunit alpha type-6 isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables NF-kappaB binding	IPI IPI: Inferred from physical interaction	14743216	GOA
enables RNA binding	IDA IDA: Inferred from direct assay	7681138	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	12376572	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in positive regulation of NF-kappaB transcription factor activity	IMP IMP: Inferred from mutant phenotype	16845397	GOA
involved in proteolysis involved in protein catabolic process	IMP IMP: Inferred from mutant phenotype	16845397	GOA

Cellular Component GO Annotation	Evidence	References	Source
is active in cytoplasm	IDA IDA: Inferred from direct assay	34711951	GOA
is active in nucleus	IDA IDA: Inferred from direct assay	34711951	GOA
located in nucleus	IDA IDA: Inferred from direct assay	7681138	GOA
part of proteasome complex	IDA IDA: Inferred from direct assay	17323924	GOA
part of proteasome core complex	IDA IDA: Inferred from direct assay	34711951	GOA
part of proteasome core complex, alpha-subunit complex	IDA IDA: Inferred from direct assay	9096325	GOA
located in ribosome	IDA IDA: Inferred from direct assay	7681138	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PSMA6 Protein Structure

Proteasome_A_N

Proteasome

0
100
200
246 a.a.

Protein Preferred Names	Protein Names
proteasome subunit alpha type-6	27 kDa prosomal protein

PSMA6 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	PSMA6	P60900	KRTAP4-2	Homo sapiens	Q9BYR5	Y2H Prey Pooling	25416956
Intra	PSMA6	P60900	SMCO3	Homo sapiens	A2RU48	Y2H Array	32296183
Intra	PSMA6	P60900	SMCO3	Homo sapiens	A2RU48	Y2H Prey Pooling	32296183
Intra	PSMA6	P60900	RTP5	Homo sapiens	Q14D33	Y2H Prey Pooling	25416956
Intra	PSMA6	P60900	RTP5	Homo sapiens	Q14D33	Y2H Array	25416956
Intra	PSMA6	P60900	UCHL5	Homo sapiens	Q9Y5K5	Anti Tag CoIP	35271311
Intra	PSMA6	P60900	C19orf47	Homo sapiens	Q8N9M1-2	Y2H Prey Pooling	32296183
Intra	PSMA6	P60900	C19orf47	Homo sapiens	Q8N9M1-2	Validated Y2H	32296183
Intra	PSMA6	P60900	C19orf47	Homo sapiens	Q8N9M1-2	Y2H Array	32296183
Intra	PSMA6	P60900	TEPSIN	Homo sapiens	Q96N21	Y2H Prey Pooling	32296183
Intra	PSMA6	P60900	TEPSIN	Homo sapiens	Q96N21	Validated Y2H	32296183
Intra	PSMA6	P60900	TEPSIN	Homo sapiens	Q96N21	Y2H Array	32296183
Intra	PSMA6	P60900	TRIM39	Homo sapiens	Q9HCM9-2	Y2H Prey Pooling	32296183
Intra	PSMA6	P60900	TRIM39	Homo sapiens	Q9HCM9-2	Validated Y2H	32296183
Intra	PSMA6	P60900	TRIM39	Homo sapiens	Q9HCM9-2	Y2H Array	32296183
Intra	PSMA6	P60900	RNF170	Homo sapiens	Q96K19	Validated Y2H	25416956
Intra	PSMA6	P60900	ZKSCAN4	Homo sapiens	Q969J2	Validated Y2H	32296183
Intra	PSMA6	P60900	ZKSCAN4	Homo sapiens	Q969J2	Y2H Array	32296183
Intra	PSMA6	P60900	ZKSCAN4	Homo sapiens	Q969J2	Y2H Prey Pooling	32296183
Intra	PSMA6	P60900	PSMA3	Homo sapiens	P25788	Anti Bait CoIP	17948026
Intra	PSMA6	P60900	PSMA3	Homo sapiens	P25788	Y2H Prey Pooling	32296183
Intra	PSMA6	P60900	PSMA3	Homo sapiens	P25788	Y2H Array	32296183
Intra	PSMA6	P60900	PSMA3	Homo sapiens	P25788	Validated Y2H	25416956
Intra	PSMA6	P60900	PSMA3	Homo sapiens	P25788	Y2H Pooling	16169070
Intra	PSMA6	P60900	PSMD3	Homo sapiens	O43242	Anti Tag CoIP	35271311
Intra	PSMA6	P60900	PSMD3	Homo sapiens	O43242	Y2H Prey Pooling	32296183
Intra	PSMA6	P60900	PSMD3	Homo sapiens	O43242	Y2H Array	32296183
Intra	PSMA6	P60900	PSMA4	Homo sapiens	P25789	Pull Down	15225636
Intra	PSMA6	P60900	PSMA4	Homo sapiens	P25789	Anti Bait CoIP	19581590
Intra	PSMA6	P60900	PSMA4	Homo sapiens	P25789	Anti Bait CoIP	17948026
Intra	PSMA6	P60900	POLR2L	Homo sapiens	P62875	Y2H Prey Pooling	32296183
Intra	PSMA6	P60900	POLR2L	Homo sapiens	P62875	Validated Y2H	32296183
Intra	PSMA6	P60900	POLR2L	Homo sapiens	P62875	Y2H Array	32296183
Intra	PSMA6	P60900	ZNF596	Homo sapiens	Q8TC21	Validated Y2H	32296183
Intra	PSMA6	P60900	ZNF596	Homo sapiens	Q8TC21	Y2H Prey Pooling	32296183
Intra	PSMA6	P60900	ZNF596	Homo sapiens	Q8TC21	Y2H Array	32296183
Intra	PSMA6	P60900	CADM1	Homo sapiens	Q9BY67	Y2H Array	25416956
Intra	PSMA6	P60900	ZBTB44	Homo sapiens	Q8NCP5	Validated Y2H	25416956
Intra	PSMA6	P60900	ZBTB44	Homo sapiens	Q8NCP5	Y2H Array	25416956
Intra	PSMA6	P60900	PSMA2	Homo sapiens	P25787	Anti Tag CoIP	35271311
Intra	PSMA6	P60900	PSMA2	Homo sapiens	P25787	Anti Bait CoIP	17948026
Intra	PSMA6	P60900	PSMA7	Homo sapiens	O14818	Y2H	14733938
Intra	PSMA6	P60900	PSMA7	Homo sapiens	O14818	Pull Down	15225636
Intra	PSMA6	P60900	PSMA7	Homo sapiens	O14818	Anti Tag CoIP	35271311
Intra	PSMA6	P60900	PSMA7	Homo sapiens	O14818	Anti Bait CoIP	17948026
Intra	PSMA6	P60900	PSMA7	Homo sapiens	O14818	Y2H	17948026
Intra	PSMA6	P60900	PSMA7	Homo sapiens	O14818	Y2H	15225636
Intra	PSMA6	P60900	ERH	Homo sapiens	P84090	Validated Y2H	32296183
Intra	PSMA6	P60900	ERH	Homo sapiens	P84090	Y2H Prey Pooling	32296183
Intra	PSMA6	P60900	ERH	Homo sapiens	P84090	Y2H Array	32296183
Intra	PSMA6	P60900	TSPYL	Homo sapiens	Q6FI91	Y2H Prey Pooling	32296183
Intra	PSMA6	P60900	TSPYL	Homo sapiens	Q6FI91	Validated Y2H	32296183
Intra	PSMA6	P60900	TSPYL	Homo sapiens	Q6FI91	Y2H Array	32296183
Intra	PSMA6	P60900	BRME1	Homo sapiens	Q0VDD7	Validated Y2H	25416956
Intra	PSMA6	P60900	BRME1	Homo sapiens	Q0VDD7	Y2H Prey Pooling	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

PSMA6 Antibodies

Cat. No.	상품명	신청	Reactivity
HY-P82004	Proteasome alpha 6 Antibody (YA1749)	WB, ICC/IF	Human, Mouse, Rat
HY-P82004A	Proteasome alpha 6 Antibody (YA1749)(PBS only)	WB, ICC/IF	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Myocardial Infarction	Heart Attack Myocardial Infarction, Susceptibility To Myocardial Infarction 1 Myocardial Infarction, Protection Against Myocardial Infarction, Decreased Susceptibility To Myocardial Infarction, Decreased Myocardial Infarct MCI1 Premature Myocardial Infarction Myocardial Infarction, Susceptibility To, Type 1
Combined Oxidative Phosphorylation Deficiency 8	COXPD8 Combined Oxidative Phosphorylation Defect Type 8 Cardiomyopathy, Hypertrophic Mitochondrial, Fatal Infantile Cardiomyopathy Hypertrophic Mitochondrial Fatal Infantile Combined Oxidative Phosphorylation Deficiency, Type 8
Renal Wilms' Tumor	Nonanaplastic Renal Wilm'S Tumor Nonanaplastic Renal Wilm'S Tumour Nonanaplastic Renal Wilms Tumor Renal Wilms' Tumour
Arrhythmogenic Right Ventricular Dysplasia, Familial, 11	Arrhythmogenic Right Ventricular Dysplasia 11 ARVD11 Arrhythmogenic Right Ventricular Cardiomyopathy 11 Arvc11 Arrhythmogenic Right Ventricular Dysplasia 11 With Mild Palmoplantar Keratoderma And Woolly Hair Arrhythmogenic Right Ventricular Dysplasia, Familial, 11, With Mild Palmoplantar Keratoderma And Woolly Hair Familial Arrhythmogenic Right Ventricular Dysplasia 11 Arrhythmogenic Right Ventricular Dysplasia 11, Familial, And Mild Palmoplantar Keratoderma And Woolly Hair ARVD11PK Arvd And Mild Palmoplantar Keratoderma With Or Without Woolly Hair Dysplasia, Ventricular, Right, Arrhythmogenic, Type 11
Cystic Fibrosis	Mucoviscidosis CF Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis Cystic Fibrosis Lung Disease, Modifier Of Cystic Fibrosis Of Pancreas Fibrocystic Disease Of Pancreas Cf - [Cystic Fibrosis] Cystic Fibrosis Nos Fibrocystic Disease Fibrocystic Disease Of The Pancreas Mucoviscidosis Of Pancreas Nonproliferative Fibrocystic Disease Pancreatic Cystic Fibrosis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	상품명	효과	Purity	Rare Diseases
HY-P11485	JR11-PEG3-HBED-CC-PSMA-03		/	Unkown
HY-P11488	JR11-PEG3-DOTA-PSMA-03	Ligand	/	Unkown
HY-RS11296	PSMA6 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	PSMA6	RGD	RGD:61849
Felis catus	PSMA6	VGNC	VGNC:80877
Bos taurus	PSMA6	VGNC	VGNC:33441
Mus musculus	PSMA6	MGD	MGI:1347006
Canis familiaris	PSMA6	VGNC	VGNC:45091
Others	PSMA6	NCBI