PSMA6 - proteasome 20S subunit alpha 6 Gene

Homo sapiens

Also known as IOTA; p27K; PROS27

Gene ID: 5687 | Gene type: protein coding

About PSMA6

Cytogenetic location: 14q13.2 Genomic coordinates (GRCh38): 14:35,278,558-35,317,493 (from NCBI)

This gene has 17 transcripts (splice variants), 272 orthologues, 18 paralogues and is associated with 1 phenotype. Ubiquitous expression in testis (RPKM 34.7), colon (RPKM 23.0) and 25 other tissues.

Summary

The Proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave Peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified Proteasome, the immunoproteasome, is the processing of class I MHC Peptides. This gene encodes a member of the peptidase T1A family, that is a 20S core alpha subunit. Multiple transcript variants encoding several different isoforms have been found for this gene. A pseudogene has been identified on the Y chromosome. [provided by RefSeq, Aug 2013]

PSMA6 Products(4)

mRNA	Protein	Name
NM_001282232.1	NP_001269161.1	proteasome subunit alpha type-6 isoform b
NM_001282233.1	NP_001269162.1	proteasome subunit alpha type-6 isoform b
NM_001282234.1	NP_001269163.1	proteasome subunit alpha type-6 isoform c
NM_002791.3	NP_002782.1	proteasome subunit alpha type-6 isoform a

PSMA6 Protein Structure

Proteasome_A_N

Proteasome

0
100
200
246 a.a.

Protein Preferred Names

Protein Names

proteasome subunit alpha type-6

27 kDa prosomal protein

Related Diseases

Diseases

Alias

Myocardial Infarction

Heart Attack	Myocardial Infarction, Susceptibility To
Myocardial Infarction 1	Myocardial Infarction, Protection Against
Myocardial Infarction, Decreased Susceptibility To	Myocardial Infarction, Decreased
Myocardial Infarct	MCI1
Premature Myocardial Infarction	Myocardial Infarction, Susceptibility To, Type 1

Combined Oxidative Phosphorylation Deficiency 8

COXPD8	Combined Oxidative Phosphorylation Defect Type 8
Cardiomyopathy, Hypertrophic Mitochondrial, Fatal Infantile	Cardiomyopathy Hypertrophic Mitochondrial Fatal Infantile
Combined Oxidative Phosphorylation Deficiency, Type 8

Renal Wilms' Tumor

Nonanaplastic Renal Wilm'S Tumor	Nonanaplastic Renal Wilm'S Tumour
Nonanaplastic Renal Wilms Tumor	Renal Wilms' Tumour

Arrhythmogenic Right Ventricular Dysplasia, Familial, 11

Arrhythmogenic Right Ventricular Dysplasia 11	ARVD11
Arrhythmogenic Right Ventricular Cardiomyopathy 11	Arvc11
Arrhythmogenic Right Ventricular Dysplasia 11 With Mild Palmoplantar Keratoderma And Woolly Hair	Arrhythmogenic Right Ventricular Dysplasia, Familial, 11, With Mild Palmoplantar Keratoderma And Woolly Hair
Familial Arrhythmogenic Right Ventricular Dysplasia 11	Arrhythmogenic Right Ventricular Dysplasia 11, Familial, And Mild Palmoplantar Keratoderma And Woolly Hair
ARVD11PK	Arvd And Mild Palmoplantar Keratoderma With Or Without Woolly Hair
Dysplasia, Ventricular, Right, Arrhythmogenic, Type 11

Cystic Fibrosis

Mucoviscidosis	CF
Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis	Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis
Cystic Fibrosis Lung Disease, Modifier Of	Cystic Fibrosis Of Pancreas
Fibrocystic Disease Of Pancreas	Cf - [Cystic Fibrosis]
Cystic Fibrosis Nos	Fibrocystic Disease
Fibrocystic Disease Of The Pancreas	Mucoviscidosis Of Pancreas
Nonproliferative Fibrocystic Disease	Pancreatic Cystic Fibrosis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11296	PSMA6 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	PSMA6	RGD	RGD:61849
Felis catus	PSMA6	VGNC	VGNC:80877
Bos taurus	PSMA6	VGNC	VGNC:33441
Mus musculus	PSMA6	MGD	MGI:1347006
Canis familiaris	PSMA6	VGNC	VGNC:45091

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