POLR2L - RNA polymerase II, I and III subunit L Gene

Also Known as RBP10; RPB10; RPABC5; RPB7.6; hRPB7.6; RPB10beta

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 5441

About POLR2L

Cytogenetic location: 11p15.5 Genomic coordinates (GRCh38): 11:839,721-842,529 (from NCBI)

This gene has 2 transcripts (splice variants), 197 orthologues and 1 paralogue. Ubiquitous expression in fat (RPKM 85.5), kidney (RPKM 42.9) and 25 other tissues.

Summary

This gene encodes a subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. The product of this gene contains four conserved cysteines characteristic of an atypical zinc-binding domain. Like its counterpart in yeast, this subunit may be shared by the Other two DNA-directed RNA polymerases. [provided by RefSeq, Jul 2008]

POLR2L Products (1)

mRNA Protein Name
NM_021128.5 NP_066951.1 DNA-directed RNA polymerases I, II, and III subunit RPABC5

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
21988832 GOA
enables zinc ion binding IDA
IDA: Inferred from direct assay
34675218 GOA
Biological Process GO Annotation Evidence References Source
involved in transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
9852112 GOA
Cellular Component GO Annotation Evidence References Source
part of RNA polymerase I complex IDA
IDA: Inferred from direct assay
34671025 GOA
part of RNA polymerase II, core complex IDA
IDA: Inferred from direct assay
9852112 GOA
part of RNA polymerase III complex IDA
IDA: Inferred from direct assay
33335104 GOA
located in nucleus IDA
IDA: Inferred from direct assay
9852112 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

POLR2L Protein Structure

RNA_pol_N

RNA_pol_N: RNA polymerases N / 8 kDa subunit (1 - 60)

  • 0
  • 67 a.a.
Protein Preferred Names Protein Names

DNA-directed RNA polymerases I, II, and III subunit RPABC5

  • DNA-directed RNA polymerase III subunit L

POLR2L Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
POLR2L P62875 TP53BP2 Homo sapiens Q13625-3
Y2H Array
25416956
Intra
POLR2L P62875 ZBTB14 Homo sapiens O43829
Y2H Array
25416956
Intra
POLR2L P62875 RPAP1 Homo sapiens Q9BWH6
Anti Tag CoIP
33961781
Intra
POLR2L P62875 RPAP1 Homo sapiens Q9BWH6
Y2H Array
25416956
Intra
POLR2L P62875 REL Homo sapiens Q04864-2
Validated Y2H
32296183
Intra
POLR2L P62875 REL Homo sapiens Q04864-2
Y2H Prey Pooling
32296183
Intra
POLR2L P62875 REL Homo sapiens Q04864-2
Y2H Array
32296183
Intra
POLR2L P62875 FAM217B Homo sapiens Q9NTX9
Y2H Array
32296183
Intra
POLR2L P62875 FAM217B Homo sapiens Q9NTX9
Y2H Prey Pooling
32296183
Intra
POLR2L P62875 FAM217B Homo sapiens Q9NTX9
Validated Y2H
32296183
Intra
POLR2L P62875 REL Homo sapiens Q04864
Y2H Prey Pooling
25416956
Intra
POLR2L P62875 TRIP13 Homo sapiens Q15645
Y2H Prey Pooling
32296183
Intra
POLR2L P62875 TRIP13 Homo sapiens Q15645
Validated Y2H
32296183
Intra
POLR2L P62875 TRIP13 Homo sapiens Q15645
Y2H Array
32296183
Intra
POLR2L P62875 POLR2D Homo sapiens O15514
Anti Tag CoIP
33961781
Intra
POLR2L P62875 POLR2D Homo sapiens O15514
Y2H
21988832
Intra
POLR2L P62875 SPAG5 Homo sapiens Q96R06
Validated Y2H
25416956
Intra
POLR2L P62875 SPAG5 Homo sapiens Q96R06
Y2H Array
25416956
Intra
POLR2L P62875 AGR2 Homo sapiens O95994
Y2H Prey Pooling
32296183
Intra
POLR2L P62875 AGR2 Homo sapiens O95994
Y2H Array
32296183
Intra
POLR2L P62875 BANP Homo sapiens Q8N9N5
Y2H Prey Pooling
25416956
Intra
POLR2L P62875 BANP Homo sapiens Q8N9N5
Validated Y2H
25416956
Intra
POLR2L P62875 NACC1 Homo sapiens Q96RE7
Y2H Array
32296183
Intra
POLR2L P62875 NACC1 Homo sapiens Q96RE7
Y2H Prey Pooling
32296183
Intra
POLR2L P62875 NACC1 Homo sapiens Q96RE7
Validated Y2H
32296183
Intra
POLR2L P62875 COIL Homo sapiens P38432
Y2H Prey Pooling
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Cockayne Syndrome

  • Cockayne'S Syndrome

  • Dwarfism-Retinal Atrophy-Deafness Syndrome

  • Neill-Dingwall Syndrome

  • Progeria-Like Syndrome

  • Progeroid Nanism

  • Cs
Hyperparathyroidism 2 With Jaw Tumors

  • Hyperparathyroidism-Jaw Tumor Syndrome

  • Hpt-Jt

  • HRPT2

  • Familial Primary Hyperparathyroidism With Multiple Ossifying Jaw Fibromas

  • Parathyroid Adenoma With Cystic Changes

  • Hereditary Hyperparathyroidism-Jaw Tumor Syndrome

  • Hyperparathyroidism 2

  • Hyperparathyroidism, Familial Primary, With Multiple Ossifying Jaw Fibromas

  • Hyperparathyroidism-Jaw Tumor Syndrome, Hereditary

  • Familial Cystic Parathyroid Adenomatosis

  • Hyperparathyroidism-Jaw Tumor Syndrome, Type 2

  • Parathyroid Adenomatosis, Familial Cystic
Hepatitis D

  • Delta Hepatitis

  • Hepatitis Delta

  • Hdv

  • Hepatitis D Virus

  • Hepatitis D Infection
Trichothiodystrophy

  • Ttd

  • Amish Brittle Hair Syndrome

  • Bids Syndrome

  • Brittle Hair-Intellectual Impairment-Decreased Fertility-Short Stature Syndrome

  • Ibids

  • Pibids

  • Trichothiodystrophy Syndromes
Sleeping Sickness

  • African Trypanosomiasis

  • African Sleeping Sickness

  • Trypanosomiasis, Human East-African

  • Trypanosomiasis, East African

  • Trypanosomiasis African

  • Trypanosomiasis, African

  • Human African Trypanosomiasis
Rapp-Hodgkin Syndrome

  • RHS

  • Anhidrotic Ectodermal Dysplasia With Cleft Lip/Palate

  • Ectodermal Dysplasia, Rapp-Hodgkin Type

  • Rapp-Hodgkin Ectodermal Dysplasia Syndrome

  • Ectodermal Dysplasia, Anhidrotic, With Cleft Lip/Palate

  • Ectodermal Dysplasia Syndrome, Rapp-Hodgkin Type

  • Edrh

  • Rapp-Hodgkin Ectodermal Dysplasia

  • Orofacial Cleft 8
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS10854 POLR2L Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus POLR2L MGD MGI:1913741
Rattus norvegicus POLR2L RGD RGD:1566209
Felis catus POLR2L VGNC VGNC:105827
Bos taurus POLR2L VGNC VGNC:33144
Others POLR2L NCBI