RPAP1 - RNA polymerase II associated protein 1 Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 26015

About RPAP1

Cytogenetic location: 15q15.1 Genomic coordinates (GRCh38): 15:41,517,176-41,544,257 (from NCBI)

This gene has 12 transcripts (splice variants) and 198 orthologues. Ubiquitous expression in testis (RPKM 6.0), ovary (RPKM 4.6) and 25 other tissues.

Summary

This protein forms part of the RNA polymerase II (RNAPII) enzyme complex and may recruit RNAPII to chromatin through its interaction with acetylated histones. [provided by RefSeq, Jul 2012]

RPAP1 Products (1)

mRNA Protein Name
NM_015540.4 NP_056355.2 RNA polymerase II-associated protein 1

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
21044950 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RPAP1 Protein Structure

RPAP1_N

RPAP1_N: RPAP1-like, N-terminal (224 - 271)

RPAP1_C

RPAP1_C: RPAP1-like, C-terminal (355 - 423)

  • 0
  • 300
  • 600
  • 900
  • 1200
  • 1393 a.a.
Protein Preferred Names Protein Names

RNA polymerase II-associated protein 1

RPAP1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
RPAP1 Q9BWH6 POLR2L Homo sapiens P62875
Y2H Prey Pooling
25416956
Intra
RPAP1 Q9BWH6 POLR2L Homo sapiens P62875
Validated Y2H
25416956
Intra
RPAP1 Q9BWH6 POT1 Homo sapiens Q9NUX5
Pull Down
21044950
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Myasthenic Syndrome, Congenital, 22

  • CMS22

  • Prepl Deficiency

  • Congenital Myasthenic Syndrome 22
Sporotrichosis

  • Rose Gardener'S Disease
Hypotonia-Cystinuria Syndrome

  • Cystinuria With Mitochondrial Disease

  • 2p21 Microdeletion Syndrome

  • HCS

  • Homozygous 2p16 Deletion Syndrome, Formerly

  • 2p21 Deletion Syndrome

  • Del(2)(P21)

  • Monosomy 2p21

  • Atypical Hypotonia-Cystinuria Syndrome

  • Atypical Hcs
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12147 RPAP1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19033 Rpap1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25522 Rpap1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus RPAP1 VGNC VGNC:34098
Canis familiaris RPAP1 VGNC VGNC:45706
Mus musculus RPAP1 MGD MGI:1916175
Rattus norvegicus RPAP1 RGD RGD:1590891
Macaca mulatta RPAP1 VGNC VGNC:76813
Felis catus RPAP1 VGNC VGNC:64728
Others RPAP1 NCBI