2. Gene
  3. POLR2D - RNA polymerase II subunit D Gene

POLR2D - RNA polymerase II subunit D Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as RBP4; RPB4; RPB16; HSRBP4; HSRPB4

Gene ID: 5433 | Gene type: protein coding

About POLR2D

Cytogenetic location: 2q14.3 Genomic coordinates (GRCh38): 2:127,843,553-127,858,155 (from NCBI)

This gene has 4 transcripts (splice variants) and 205 orthologues. Broad expression in testis (RPKM 27.2), lymph node (RPKM 9.2) and 25 other tissues.

Summary

This gene encodes the fourth largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. In yeast, this polymerase subunit is associated with the polymerase under suboptimal growth conditions and may have a stress protective role. A sequence for a ribosomal pseudogene is contained within the 3' untranslated region of the transcript from this gene. [provided by RefSeq, Jul 2008]

POLR2D Products(1)

mRNA Protein Name
NM_004805.4 NP_004796.1 DNA-directed RNA polymerase II subunit RPB4

POLR2D Protein Structure

RNA_pol_Rpb4

RNA_pol_Rpb4: RNA polymerase Rpb4 (32 - 136)

  • 0
  • 100
  • 142 a.a.
Protein Preferred Names Protein Names

DNA-directed RNA polymerase II subunit RPB4

DNA-directed RNA polymerase II 16 kDa polypeptide

Related Diseases

Diseases Alias
Nemaline Myopathy 7

NEM7

Nemaline Myopathy 7, Autosomal Recessive

Cfl2-Related Nemaline Myopathy

Myopathy, Nemaline, Type 7
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS10845 POLR2D Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris POLR2D VGNC VGNC:44795
Felis catus POLR2D VGNC VGNC:68949
Mus musculus POLR2D MGD MGI:1916491
Macaca mulatta POLR2D VGNC VGNC:76213
Bos taurus POLR2D VGNC VGNC:33138
Rattus norvegicus POLR2D RGD RGD:1308565