POLR2D - RNA polymerase II subunit D Gene

Also Known as RBP4; RPB4; RPB16; HSRBP4; HSRPB4

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 5433

About POLR2D

Cytogenetic location: 2q14.3 Genomic coordinates (GRCh38): 2:127,843,553-127,858,155 (from NCBI)

This gene has 4 transcripts (splice variants) and 205 orthologues. Broad expression in testis (RPKM 27.2), lymph node (RPKM 9.2) and 25 other tissues.

Summary

This gene encodes the fourth largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. In yeast, this polymerase subunit is associated with the polymerase under suboptimal growth conditions and may have a stress protective role. A sequence for a ribosomal pseudogene is contained within the 3' untranslated region of the transcript from this gene. [provided by RefSeq, Jul 2008]

POLR2D Products (1)

mRNA Protein Name
NM_004805.4 NP_004796.1 DNA-directed RNA polymerase II subunit RPB4

POLR2D Protein Structure

RNA_pol_Rpb4

RNA_pol_Rpb4: RNA polymerase Rpb4 (32 - 136)

  • 0
  • 100
  • 142 a.a.
Protein Preferred Names Protein Names

DNA-directed RNA polymerase II subunit RPB4

  • DNA-directed RNA polymerase II 16 kDa polypeptide

POLR2D Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
POLR2D O15514 POLR2L Homo sapiens P62875
Anti Tag CoIP
28514442
Intra
POLR2D O15514 POLR2L Homo sapiens P62875
TAP
24981860
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Nemaline Myopathy 7

  • NEM7

  • Nemaline Myopathy 7, Autosomal Recessive

  • Cfl2-Related Nemaline Myopathy

  • Myopathy, Nemaline, Type 7
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS10845 POLR2D Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris POLR2D VGNC VGNC:44795
Felis catus POLR2D VGNC VGNC:68949
Mus musculus POLR2D MGD MGI:1916491
Macaca mulatta POLR2D VGNC VGNC:76213
Bos taurus POLR2D VGNC VGNC:33138
Rattus norvegicus POLR2D RGD RGD:1308565
Others POLR2D NCBI