PSMD3 - proteasome 26S subunit, non-ATPase 3 Gene

Also Known as S3; P58; RPN3; TSTA2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 5709

About PSMD3

Cytogenetic location: 17q21.1 Genomic coordinates (GRCh38): 17:39,980,807-39,997,959 (from NCBI)

This gene has 5 transcripts (splice variants), 207 orthologues and 1 paralogue. Ubiquitous expression in colon (RPKM 31.7), brain (RPKM 31.3) and 25 other tissues.

Summary

The 26S Proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. This gene encodes a member of the Proteasome subunit S3 family that functions as one of the non-ATPase subunits of the 19S regulator lid. Single nucleotide polymorphisms in this gene are associated with neutrophil count. [provided by RefSeq, Jul 2012]

PSMD3 Products (1)

mRNA Protein Name
NM_002809.4 NP_002800.2 26S proteasome non-ATPase regulatory subunit 3

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
15147878 GOA
Cellular Component GO Annotation Evidence References Source
part of proteasome complex IDA
IDA: Inferred from direct assay
17323924 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PSMD3 Protein Structure

PCI

PCI: PCI domain (359 - 461)

Rpn3_C

Rpn3_C: Proteasome regulatory subunit C-terminal (465 - 531)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 534 a.a.
Protein Preferred Names Protein Names

26S proteasome non-ATPase regulatory subunit 3

  • 26S proteasome regulatory subunit RPN3

PSMD3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
PSMD3 O43242 NFKBIA Homo sapiens P25963
Y2H Prey Pooling
32296183
Intra
PSMD3 O43242 NFKBIA Homo sapiens P25963
Validated Y2H
32296183
Intra
PSMD3 O43242 NFKBIA Homo sapiens P25963
Y2H Array
32296183
Intra
PSMD3 O43242 PSMD2 Homo sapiens Q13200
Anti Tag CoIP
35271311
Intra
PSMD3 O43242 PSMA6 Homo sapiens P60900
Validated Y2H
32296183
Intra
PSMD3 O43242 PSMD4 Homo sapiens P55036
Anti Tag CoIP
35271311
Intra
PSMD3 O43242 HTT Homo sapiens P42858
Validated Y2H
32814053
Intra
PSMD3 O43242 HTT Homo sapiens P42858
Y2H Pooling
32814053
Intra
PSMD3 O43242 HTT Homo sapiens P42858
Y2H Array
32814053
Intra
PSMD3 O43242 ZBTB43 Homo sapiens O43298
Y2H Array
31515488
Intra
PSMD3 O43242 ZBTB43 Homo sapiens O43298
Validated Y2H
32296183
Intra
PSMD3 O43242 ZBTB43 Homo sapiens O43298
Y2H Prey Pooling
32296183
Intra
PSMD3 O43242 ZBTB43 Homo sapiens O43298
Y2H Prey Pooling
25416956
Intra
PSMD3 O43242 ZBTB43 Homo sapiens O43298
Y2H Array
32296183
Intra
PSMD3 O43242 CEP44 Homo sapiens Q9C0F1
Validated Y2H
25416956
Intra
PSMD3 O43242 CEP44 Homo sapiens Q9C0F1
Y2H Array
25416956
Intra
PSMD3 O43242 CEP44 Homo sapiens Q9C0F1
Y2H Prey Pooling
25416956
Intra
PSMD3 O43242 SEM1 Homo sapiens P60896
Y2H Prey Pooling
25416956
Intra
PSMD3 O43242 SEM1 Homo sapiens P60896
Validated Y2H
25416956
Intra
PSMD3 O43242 SEM1 Homo sapiens P60896
Y2H Array
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Hypothyroidism, Congenital, Nongoitrous, 2

  • Thyroid Dysgenesis

  • CHNG2

  • Thyroid Hypoplasia

  • Thyroid Hemiagenesis

  • Thyroid Agenesis

  • Athyreotic Hypothyroidism

  • Rtsh

  • Thyrotropin Resistance

  • Hypothyroidism, Congenital, Due To Thyroid Dysgenesis Or Hypoplasia

  • Congenital Nongoitrous Hypothyroidism 2

  • Thyroid, Ectopic

  • Hypothyroidism, Congenital, Due To Thyroid Dysgenesis

  • Hypothyroidism, Athyreotic

  • Thyrotropin

  • Resistance To Thyrotropin

  • Congenital Hypothyroidism Due To Thyroid Dysgenesis Or Hypoplasia

  • Hypothyroidism, Congenital, Non-Goitrous, 2

  • Congenital Hypothyroidism Due To Thyroid Dysgenesis

  • Thyroid-Stimulating Hormone Resistance

  • Thyroid Ectopic

  • Ectopic Thyroid

  • Hypothyroidism, Congenital, Nongoitrous, 3

  • Thyroid Hormone Resistance Syndrome

  • Hypothyroidism, Congenital, Nongoitrous, 1
Glioblastoma Proneural Subtype
Inflammatory Bowel Disease 22

  • IBD22
Cystic Fibrosis

  • Mucoviscidosis

  • CF

  • Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis

  • Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis

  • Cystic Fibrosis Lung Disease, Modifier Of

  • Cystic Fibrosis Of Pancreas

  • Fibrocystic Disease Of Pancreas

  • Cf - [Cystic Fibrosis]

  • Cystic Fibrosis Nos

  • Fibrocystic Disease

  • Fibrocystic Disease Of The Pancreas

  • Mucoviscidosis Of Pancreas

  • Nonproliferative Fibrocystic Disease

  • Pancreatic Cystic Fibrosis
Angelman Syndrome

  • AS

  • Happy Puppet Syndrome

  • Happy Puppet Syndrome, Formerly

  • Puppetlike Syndrome
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS22750 Psmd3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS11324 PSMD3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29264 Psmd3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus PSMD3 RGD RGD:1311470
Macaca mulatta PSMD3 VGNC VGNC:76452
Mus musculus PSMD3 MGD MGI:98858
Felis catus PSMD3 VGNC VGNC:69124
Bos taurus PSMD3 VGNC VGNC:33467
Canis familiaris PSMD3 VGNC VGNC:45112
Others PSMD3 NCBI