2. Gene
  3. NFRKB - nuclear factor related to kappaB binding protein Gene

NFRKB - nuclear factor related to kappaB binding protein Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as INO80G

Gene ID: 4798 | Gene type: protein coding

About NFRKB

Cytogenetic location: 11q24.3 Genomic coordinates (GRCh38): 11:129,863,636-129,895,578 (from NCBI)

This gene has 12 transcripts (splice variants) and 203 orthologues. Ubiquitous expression in testis (RPKM 11.1), ovary (RPKM 7.8) and 25 other tissues.

Summary

Enables protease binding activity. Predicted to be involved in DNA recombination and DNA repair. Located in nucleoplasm. Colocalizes with Ino80 complex. [provided by Alliance of Genome Resources, Apr 2022]

NFRKB Products(2)

mRNA Protein Name
NM_001143835.2 NP_001137307.1 nuclear factor related to kappa-B-binding protein isoform 1
NM_006165.4 NP_006156.2 nuclear factor related to kappa-B-binding protein isoform 2

NFRKB Protein Structure

NFRKB_winged

NFRKB_winged: NFRKB Winged Helix-like (379 - 478)

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  • 1299 a.a.
Protein Preferred Names Protein Names

nuclear factor related to kappa-B-binding protein

DNA-binding protein R kappa B

Related Diseases

Diseases Alias
Jacobsen Syndrome

Chromosome 11q Deletion Syndrome

Partial 11q Monosomy Syndrome

Jacobsen Distal 11q Deletion Syndrome

JBS

11q Partial Monosomy Syndrome

Chromosome 11q Deletion

11q Deletion

11q Monosomy

Deletion 11q

Monosomy 11q

Partial Monosomy 11q

11q Deletion Disorder

11q Deletion Syndrome

11q Terminal Deletion Disorder

11q- Deletion Syndrome

11q23 Deletion Disorder

Jacobsen Thrombocytopenia

11q Terminal Deletion Syndrome

Del(11)(Q23.3)

Del(11)(Qter)

Distal Deletion 11q

Distal Monosomy 11q

Monosomy 11qter

Telomeric Deletion 11q

Paris-Trousseau Thrombocytopenia
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS09266 NFRKB Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus NFRKB RGD RGD:1310558
Bos taurus NFRKB VGNC VGNC:32051
Felis catus NFRKB VGNC VGNC:68489
Mus musculus NFRKB MGD MGI:2442410
Macaca mulatta NFRKB VGNC VGNC:75343
Canis familiaris NFRKB VGNC VGNC:43786