ADRM1 - ADRM1 26S proteasome ubiquitin receptor Gene

Homo sapiens

Also known as ARM1; ARM-1; GP110; PSMD16

Gene ID: 11047 | Gene type: protein coding

About ADRM1

Cytogenetic location: 20q13.33 Genomic coordinates (GRCh38): 20:62,302,896-62,308,862 (from NCBI)

This gene has 5 transcripts (splice variants) and 260 orthologues. Ubiquitous expression in testis (RPKM 31.4), fat (RPKM 17.5) and 25 other tissues.

Summary

This gene encodes a member of the adhesion regulating molecule 1 protein family. The encoded protein is a component of the Proteasome where it acts as a ubiquitin receptor and recruits the deubiquitinating Enzyme, ubiquitin carboxyl-terminal hydrolase L5. Increased levels of the encoded protein are associated with increased cell adhesion, which is likely an indirect effect of this intracellular protein. Dysregulation of this gene has been implicated in carcinogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

ADRM1 Products(4)

mRNA	Protein	Name
NM_001281437.1	NP_001268366.1	proteasomal ubiquitin receptor ADRM1 isoform 2
NM_001281438.1	NP_001268367.1	proteasomal ubiquitin receptor ADRM1 isoform 2
NM_007002.4	NP_008933.2	proteasomal ubiquitin receptor ADRM1 isoform 1
NM_175573.2	NP_783163.1	proteasomal ubiquitin receptor ADRM1 isoform 1

ADRM1 Protein Structure

Proteasom_Rpn13

0
100
200
300
407 a.a.

Protein Preferred Names

Protein Names

proteasomal ubiquitin receptor ADRM1

110 kDa cell membrane glycoprotein

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00417	ADRM1 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	ADRM1	VGNC	VGNC:59659
Rattus norvegicus	ADRM1	RGD	RGD:69248
Canis familiaris	ADRM1	VGNC	VGNC:37678
Mus musculus	ADRM1	MGD	MGI:1929289
Macaca mulatta	ADRM1	VGNC	VGNC:69613
Bos taurus	ADRM1	VGNC	VGNC:25699

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