PSMD1 - proteasome 26S subunit, non-ATPase 1 Gene

Homo sapiens

Also known as S1; P112; Rpn2

Gene ID: 5707 | Gene type: protein coding

About PSMD1

Cytogenetic location: 2q37.1 Genomic coordinates (GRCh38): 2:231,056,867-231,172,827 (from NCBI)

This gene has 37 transcripts (splice variants), 212 orthologues and 1 paralogue. Ubiquitous expression in brain (RPKM 24.7), appendix (RPKM 17.2) and 25 other tissues.

Summary

The 26S Proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave Peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified Proteasome, the immunoproteasome, is the processing of class I MHC Peptides. This gene encodes the largest non-ATPase subunit of the 19S regulator lid, which is responsible for substrate recognition and binding. There is evidence that this Proteasome and its subunits interact with Viral Proteins, including those of coronaviruses. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Aug 2020]

PSMD1 Products(2)

mRNA	Protein	Name
NM_001191037.2	NP_001177966.1	26S proteasome non-ATPase regulatory subunit 1 isoform 2
NM_002807.4	NP_002798.2	26S proteasome non-ATPase regulatory subunit 1 isoform 1

PSMD1 Protein Structure

PC_rep

HEAT_2

0
200
400
600
800
953 a.a.

Protein Preferred Names

Protein Names

26S proteasome non-ATPase regulatory subunit 1

26S proteasome regulatory subunit RPN2

Related Diseases

Diseases

Alias

Cystic Fibrosis

Mucoviscidosis	CF
Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis	Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis
Cystic Fibrosis Lung Disease, Modifier Of	Cystic Fibrosis Of Pancreas
Fibrocystic Disease Of Pancreas	Cf - [Cystic Fibrosis]
Cystic Fibrosis Nos	Fibrocystic Disease
Fibrocystic Disease Of The Pancreas	Mucoviscidosis Of Pancreas
Nonproliferative Fibrocystic Disease	Pancreatic Cystic Fibrosis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11317	PSMD1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	PSMD1	RGD	RGD:621669
Mus musculus	PSMD1	MGD	MGI:1917497
Bos taurus	PSMD1	VGNC	VGNC:33461
Macaca mulatta	PSMD1	VGNC	VGNC:76449
Canis familiaris	PSMD1	VGNC	VGNC:45105
Felis catus	PSMD1	VGNC	VGNC:69118
Others	PSMD1	NCBI

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