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YTHDC1 - YTH domain containing 1 Gene

Also Known as YT521; YT521-B

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 91746

About YTHDC1

Cytogenetic location: 4q13.2 Genomic coordinates (GRCh38): 4:68,310,387-68,350,090 (from NCBI)

This gene has 7 transcripts (splice variants), 1 gene allele, 204 orthologues and 3 paralogues. Ubiquitous expression in bone marrow (RPKM 22.7), ovary (RPKM 15.2) and 25 other tissues.

Summary

Enables N6-methyladenosine-containing RNA binding activity. Involved in mRNA export from nucleus; mRNA splice site selection; and regulation of gene expression. Located in nuclear speck and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

YTHDC1 Products (3)

mRNA	Protein	Name
NM_001031732.4	NP_001026902.1	YTH domain-containing protein 1 isoform 1
NM_001330698.2	NP_001317627.1	YTH domain-containing protein 1 isoform 3
NM_133370.4	NP_588611.2	YTH domain-containing protein 1 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables N6-methyladenosine-containing RNA reader activity	IDA IDA: Inferred from direct assay	25242552	GOA
enables RNA binding	IDA IDA: Inferred from direct assay	20167602	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	15345239	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in dosage compensation by inactivation of X chromosome	IDA IDA: Inferred from direct assay	27602518	GOA
involved in mRNA export from nucleus	IDA IDA: Inferred from direct assay	28984244	GOA
involved in mRNA splice site recognition	IDA IDA: Inferred from direct assay	20167602	GOA
involved in regulation of mRNA splicing, via spliceosome	IDA IDA: Inferred from direct assay	26876937	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in nuclear speck	IDA IDA: Inferred from direct assay	26876937	GOA
located in nucleus	IDA IDA: Inferred from direct assay	20167602	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

YTHDC1 Protein Structure

YTH

0
200
400
600
727 a.a.

Protein Preferred Names	Protein Names
YTH domain-containing protein 1	putative splicing factor YT521

YTHDC1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	YTHDC1	Q96MU7	RBMY1A1	Homo sapiens	P0DJD3-2	Y2H Prey Pooling	32296183
Intra	YTHDC1	Q96MU7	RBMY1A1	Homo sapiens	P0DJD3-2	Y2H Array	32296183
Intra	YTHDC1	Q96MU7	KRTAP10-6	Homo sapiens	P60371	Y2H Array	32296183
Intra	YTHDC1	Q96MU7	KRTAP10-6	Homo sapiens	P60371	Y2H Prey Pooling	32296183
Intra	YTHDC1	Q96MU7	PHF19	Homo sapiens	Q5T6S3	Y2H Prey Pooling	32296183
Intra	YTHDC1	Q96MU7	PHF19	Homo sapiens	Q5T6S3	Y2H Array	32296183
Intra	YTHDC1	Q96MU7	HNRNPK	Homo sapiens	P61978	Y2H Array	25416956
Intra	YTHDC1	Q96MU7	HNRNPK	Homo sapiens	P61978	Y2H Array	29892012
Intra	YTHDC1	Q96MU7	ANKRD28	Homo sapiens	O15084	Y2H Array	32296183
Intra	YTHDC1	Q96MU7	ANKRD28	Homo sapiens	O15084	Y2H Prey Pooling	32296183
Intra	YTHDC1	Q96MU7	SRPK1	Homo sapiens	Q96SB4	BiFC	23602568
Intra	YTHDC1	Q96MU7	SRPK2	Homo sapiens	P78362	Anti Tag CoIP	23602568
Intra	YTHDC1	Q96MU7	HNRNPK	Homo sapiens	P61978-2	Y2H Prey Pooling	32296183
Intra	YTHDC1	Q96MU7	HNRNPK	Homo sapiens	P61978-2	Y2H Array	32296183
Intra	YTHDC1	Q96MU7	KHDRBS3	Homo sapiens	O75525	Y2H Prey Pooling	32296183
Intra	YTHDC1	Q96MU7	KHDRBS3	Homo sapiens	O75525	Y2H Array	32296183
Intra	YTHDC1	Q96MU7	TRA2B	Homo sapiens	P62995	Y2H Array	32296183
Intra	YTHDC1	Q96MU7	TRA2B	Homo sapiens	P62995	Y2H Prey Pooling	32296183
Intra	YTHDC1	Q96MU7	DVL3	Homo sapiens	Q92997	Y2H Prey Pooling	25416956
Intra	YTHDC1	Q96MU7	DVL3	Homo sapiens	Q92997	Validated Y2H	25416956
Intra	YTHDC1	Q96MU7	DVL3	Homo sapiens	Q92997	Y2H Prey Pooling	32296183
Intra	YTHDC1	Q96MU7	DVL3	Homo sapiens	Q92997	Y2H Array	25416956
Intra	YTHDC1	Q96MU7	DVL3	Homo sapiens	Q92997	Y2H Array	32296183
Intra	YTHDC1	Q96MU7	SDCBP2	Homo sapiens	Q9H190	Validated Y2H	32296183
Intra	YTHDC1	Q96MU7	SDCBP2	Homo sapiens	Q9H190	Y2H Array	25416956
Intra	YTHDC1	Q96MU7	SDCBP2	Homo sapiens	Q9H190	Y2H Array	32296183
Intra	YTHDC1	Q96MU7	SDCBP2	Homo sapiens	Q9H190	Y2H Array	31515488
Intra	YTHDC1	Q96MU7	SDCBP2	Homo sapiens	Q9H190	Validated Y2H	25416956
Intra	YTHDC1	Q96MU7	SDCBP2	Homo sapiens	Q9H190	Y2H Prey Pooling	32296183
Intra	YTHDC1	Q96MU7	KHDRBS2	Homo sapiens	Q5VWX1	Y2H Array	32296183
Intra	YTHDC1	Q96MU7	KHDRBS2	Homo sapiens	Q5VWX1	Y2H Prey Pooling	25416956
Intra	YTHDC1	Q96MU7	KHDRBS2	Homo sapiens	Q5VWX1	Validated Y2H	25416956
Intra	YTHDC1	Q96MU7	KHDRBS2	Homo sapiens	Q5VWX1	Y2H Prey Pooling	32296183
Intra	YTHDC1	Q96MU7	CLK2	Homo sapiens	P49760	Y2H Array	32296183
Intra	YTHDC1	Q96MU7	CLK2	Homo sapiens	P49760	Y2H Prey Pooling	32296183
Intra	YTHDC1	Q96MU7	PICK1	Homo sapiens	Q9NRD5	Y2H Prey Pooling	32296183
Intra	YTHDC1	Q96MU7	PICK1	Homo sapiens	Q9NRD5	Validated Y2H	32296183
Intra	YTHDC1	Q96MU7	PICK1	Homo sapiens	Q9NRD5	Y2H Array	32296183
Intra	YTHDC1	Q96MU7	RBMY1F	Homo sapiens	Q15415	Y2H Prey Pooling	25416956
Intra	YTHDC1	Q96MU7	RBMY1F	Homo sapiens	Q15415	Y2H Prey Pooling	32296183
Intra	YTHDC1	Q96MU7	RBMY1F	Homo sapiens	Q15415	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

YTHDC1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P87148	YTHDC1 Antibody (YA6841)	WB, ICC/IF, FC	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Hepatoblastoma
Wilms Tumor 1	Nephroblastoma Wilms Tumor WT1 Wilms' Tumor Bilateral Wilms Tumor Wilms Tumor, Type 1 Wilms Tumor, Somatic Adult Nephroblastoma Wt1 Disorder Renal Embryonic Tumor Adult Kidney Wilms Tumor Childhood Kidney Wilms Tumor Nonanaplastic Kidney Wilms Tumor
Autism Spectrum Disorder	Asd Autism Spectrum Disorders Autistic Continuum Pervasive Developmental Disorder Pervasive Development Disorder Autistic Behavior Autistic Disorder Autistic Autistic Disorder Of Childhood Onset Infantile Autism Childhood Autism Kanner Syndrome Pervasive Developmental Delay Nos Pervasive Developmental Disorder, Not Otherwise Specified
Leukemia, Acute Myeloid	Acute Myeloid Leukemia Leukemia, Acute Myelogenous Acute Myelogenous Leukemia AML Leukemia, Acute Myeloid, Susceptibility To Acute Myeloblastic Leukemia Leukemia, Acute Myeloid, Reduced Survival In, Somatic Acute Myeloid Leukaemia Leukemia, Myelocytic, Acute Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome Secondary Aml Acute Myelocytic Leukemia Acute Myeloid Leukemia, Somatic Leukemia, Acute Myeloid, Somatic Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic Acute Myeloblastic Leukaemia Acute Myelogenous Leukaemia Aml - Acute Myeloid Leukemia Acute Myeloid Leukemia With Cebpa Somatic Mutations Aml With Cebpa Somatic Mutations Inherited Acute Myeloid Leukemia Familial Aml Inherited Aml Pure Familial Aml Pure Familial Acute Myeloid Leukemia Secondary Acute Myeloid Leukemia Therapy-Related Aml And Myelodysplastic Syndrome Acute Myeloid Leukemia, Secondary Acute Non-Lymphoblastic Leukemia Acute Non-Lymphocytic Leukemia Acute Biphenotypic Leukemia Acute Undifferentiated Leukemia Acute Myeloblastic Leukaemia With Multilineage Dysplasia Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission Acute Myeloid Leukaemia With Myelodysplasia-Related Features
Retinitis Pigmentosa	RP Rod-Cone Dystrophy Autosomal Recessive Retinitis Pigmentosa Non-Syndromic Retinitis Pigmentosa Pericentral Pigmentary Retinopathy Pigmentary Retinopathy Tapetoretinal Degeneration Rcd Retinitis Pigmentosa Autosomal Recessive ARRP Retinitis Pigmentosa, Autosomal Recessive Retinitis Pigmentosa 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-168610	YTH-IN-1	Inhibitor	98.66%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	YTHDC1	MGD	MGI:2443713
Rattus norvegicus	YTHDC1	RGD	RGD:621706
Canis familiaris	YTHDC1	VGNC	VGNC:48503
Felis catus	YTHDC1	VGNC	VGNC:67150
Macaca mulatta	YTHDC1	VGNC	VGNC:79860
Bos taurus	YTHDC1	VGNC	VGNC:37039
Others	YTHDC1	NCBI