2. Epigenetics
  3. Histone Methyltransferase
  4. UNC7242

UNC7242 is an antagonist that binds to the Tudor domains of PHF1 and PHF19, with a Kd of 1.13 μM for PHF1 and 0.64 μM for PHF19. UNC7242 fails to displace full-length PHF1 or PHF19 from H3K36me3 nucleosomes or chromatin. UNC7242 can be used in studies related to multiple myeloma, endometrial stromal sarcoma, and ossifying fibromyxoid tumor.

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UNC7242

UNC7242 Chemical Structure

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UNC7242 Related Antibodies

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EZH1 EZH2 DOT1L SMYD2 SMYD3 SUV39H2/KMT1B EHMT2/G9a/KMT1C EHMT1/GLP/KMT1D ASH1L/KMT2H SETDB1/KMT2G SETD2/KMT3A NSD2/MMSET/WHSC1 NSD3/WHSC1L1 SETD7/KMT7 SETD8/KMT5A PRMT1 PRMT3 PRMT4 PRMT5 PRMT6 PRMT7 PRMT8

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Description

UNC7242 is an antagonist that binds to the Tudor domains of PHF1 and PHF19, with a Kd of 1.13 μM for PHF1 and 0.64 μM for PHF19. UNC7242 fails to displace full-length PHF1 or PHF19 from H3K36me3 nucleosomes or chromatin. UNC7242 can be used in studies related to multiple myeloma, endometrial stromal sarcoma, and ossifying fibromyxoid tumor[1].

In Vitro

UNC7242 binds to the isolated PHF1 Tudor domain with a Kd value of 1.13 ± 0.04 μM, and binds to the isolated PHF19 Tudor domain with a Kd value of 0.64 ± 0.14 μM[1].
UNC7242 (100 μM; 2 h) does not significantly displace endogenous PHF19 from chromatin in Jurkat N6 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

UNC7242 Related Antibodies
Molecular Weight

376.88

Formula

C19H25ClN4O2
SMILES

COC1=CC2=NC(Cl)=NC(N3CCCN(CC3)CC4CC4)=C2C=C1OC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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UNC7242 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

UNC7242UNC 7242UNC-7242Histone MethyltransferaseCBX7 chromodomainPHF19 Tudor domainMPP8 chromodomainH3K36me3 nucleosomesPHF1 Tudor domainMTF2 Tudor domainUHRF1 Tudor domainchromatinmultiple myelomaSETDB1 Tudor domainInhibitorinhibitorinhibit

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