CAVIN3 - caveolae associated protein 3 Gene

Also Known as SRBC; HSRBC; PRKCDBP; cavin-3

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 112464

About CAVIN3

Cytogenetic location: 11p15.4 Genomic coordinates (GRCh38): 11:6,318,946-6,320,501 (from NCBI)

This gene has 4 transcripts (splice variants), 266 orthologues and 3 paralogues. Broad expression in fat (RPKM 24.8), testis (RPKM 13.9) and 19 other tissues.

Summary

The protein encoded by this gene was identified as a binding protein of the protein kinase C, delta (PRKCD). The expression of this gene in cultured cell lines is strongly induced by serum starvation. The expression of this protein was found to be down-regulated in various Cancer cell lines, suggesting the possible tumor suppressor function of this protein. [provided by RefSeq, Jul 2008]

CAVIN3 Products (1)

mRNA Protein Name
NM_145040.3 NP_659477.2 caveolae-associated protein 3

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
19262564 GOA
Cellular Component GO Annotation Evidence References Source
located in caveola IDA
IDA: Inferred from direct assay
19525939 GOA
part of protein-containing complex IDA
IDA: Inferred from direct assay
24013648 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CAVIN3 Protein Structure

PTRF_SDPR

PTRF_SDPR: PTRF/SDPR family (19 - 223)

  • 0
  • 100
  • 200
  • 261 a.a.
Protein Preferred Names Protein Names

caveolae-associated protein 3

  • protein kinase C delta binding protein

CAVIN3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
CAVIN3 Q969G5 TIMM8A Homo sapiens O60220
Y2H Array
32296183
Intra
CAVIN3 Q969G5 TIMM8A Homo sapiens O60220
Y2H Prey Pooling
32296183
Intra
CAVIN3 Q969G5 TFIP11 Homo sapiens Q9UBB9
Validated Y2H
32296183
Intra
CAVIN3 Q969G5 TFIP11 Homo sapiens Q9UBB9
Y2H Array
32296183
Intra
CAVIN3 Q969G5 TFIP11 Homo sapiens Q9UBB9
Y2H Prey Pooling
32296183
Intra
CAVIN3 Q969G5 EPS15L1 Homo sapiens Q9UBC2
Anti Tag CoIP
19262564
Intra
CAVIN3 Q969G5 CAVIN1 Homo sapiens Q6NZI2
Anti Tag CoIP
24013648
Intra
CAVIN3 Q969G5 CAVIN1 Homo sapiens Q6NZI2
Y2H Array
32296183
Intra
CAVIN3 Q969G5 CAVIN1 Homo sapiens Q6NZI2
Y2H Prey Pooling
32296183
Intra
CAVIN3 Q969G5 NUP62 Homo sapiens P37198
Y2H Prey Pooling
32296183
Intra
CAVIN3 Q969G5 NUP62 Homo sapiens P37198
Y2H Array
32296183
Intra
CAVIN3 Q969G5 TPM3 Homo sapiens P06753
Y2H Array
32296183
Intra
CAVIN3 Q969G5 TPM3 Homo sapiens P06753
Y2H Prey Pooling
32296183
Intra
CAVIN3 Q969G5 GPRASP2 Homo sapiens Q96D09
Validated Y2H
32296183
Intra
CAVIN3 Q969G5 GPRASP2 Homo sapiens Q96D09
Y2H Array
32296183
Intra
CAVIN3 Q969G5 GPRASP2 Homo sapiens Q96D09
Y2H Prey Pooling
32296183
Intra
CAVIN3 Q969G5 GOLGA6L9 Homo sapiens A6NEM1
Y2H Prey Pooling
32296183
Intra
CAVIN3 Q969G5 GOLGA6L9 Homo sapiens A6NEM1
Y2H Array
32296183
Intra
CAVIN3 Q969G5 CAV1 Homo sapiens Q03135
IF
19262564
Intra
CAVIN3 Q969G5 CAV1 Homo sapiens Q03135
Anti Tag CoIP
19262564
Intra
CAVIN3 Q969G5 CAV1 Homo sapiens Q03135
Anti Tag CoIP
24013648
Intra
CAVIN3 Q969G5 MAGEA11 Homo sapiens P43364
Y2H Prey Pooling
32296183
Intra
CAVIN3 Q969G5 MAGEA11 Homo sapiens P43364
Y2H Array
32296183
Intra
CAVIN3 Q969G5 CEP70 Homo sapiens Q8NHQ1
Y2H Prey Pooling
32296183
Intra
CAVIN3 Q969G5 CEP70 Homo sapiens Q8NHQ1
Y2H Array
32296183
Intra
CAVIN3 Q969G5 CEP76 Homo sapiens Q8TAP6
Y2H Prey Pooling
32296183
Intra
CAVIN3 Q969G5 CEP76 Homo sapiens Q8TAP6
Y2H Array
32296183
Intra
CAVIN3 Q969G5 MRFAP1L1 Homo sapiens Q96HT8
Y2H Array
32296183
Intra
CAVIN3 Q969G5 MRFAP1L1 Homo sapiens Q96HT8
Y2H Prey Pooling
32296183
Intra
CAVIN3 Q969G5 MRFAP1L1 Homo sapiens Q96HT8
Validated Y2H
32296183
Intra
CAVIN3 Q969G5 MRFAP1L1 Homo sapiens Q96HT8
Validated Y2H
25416956
Intra
CAVIN3 Q969G5 MRFAP1 Homo sapiens Q9Y605
Validated Y2H
32296183
Intra
CAVIN3 Q969G5 MRFAP1 Homo sapiens Q9Y605
Y2H Prey Pooling
32296183
Intra
CAVIN3 Q969G5 MRFAP1 Homo sapiens Q9Y605
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Lipodystrophy, Congenital Generalized, Type 4

  • Congenital Generalized Lipodystrophy Type 4

  • CGL4

  • Berardinelli-Seip Congenital Lipodystrophy, Type 4, With Muscular Dystrophy

  • Lipodystrophy, Berardinelli-Seip Congenital, Type 4, With Muscular Dystrophy

  • Berardinelli-Seip Congenital Lipodystrophy Type 4 With Muscular Dystrophy

  • Generalized Congenital Lipodystrophy With Myopathy

  • Congenital Generalised Lipodystrophy Type 4

  • Generalised Congenital Lipodystrophy Type 4

  • Generalised Congenital Lipodystrophy With Myopathy

  • Generalized Congenital Lipodystrophy Type 4

  • Gcl4

  • Congenital Generalized Lipodystrophy 4

  • Berardinelli-Seip Congenital Lipodystrophy Type 4
Extracranial Neuroblastoma
Lung Cancer

  • Lung Carcinoma

  • Non-Small Cell Lung Carcinoma

  • Lung Cancer, Susceptibility To

  • Lung Cancer, Protection Against

  • Adenocarcinoma Of Lung, Somatic

  • Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

  • Nonsmall Cell Lung Cancer

  • Lung Neoplasm

  • Carcinoma Of Lung

  • Lung Non-Small Cell Carcinoma

  • Non-Small Cell Lung Cancer

  • Nsclc

  • Lung Neoplasms

  • Malignant Neoplasm Of Lung

  • Alveolar Cell Carcinoma

  • Nonsmall Cell Lung Cancer, Somatic

  • Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

  • Nonsmall Cell Lung Cancer, Susceptibility To

  • Lung Cancer, Somatic

  • Lung Cancer, Resistance To

  • Cancer Of Lung

  • Cancer Of Bronchus

  • Cancer Of The Lung

  • Lung Malignancies

  • Lung Malignant Tumors

  • Malignant Lung Tumor

  • Malignant Tumor Of Lung

  • Pulmonary Cancer

  • Pulmonary Carcinoma

  • Pulmonary Neoplasms

  • Respiratory Carcinoma

  • LNCR

  • Adenocarcinoma Of Lung

  • Neoplasm Of Lung

  • Cancer Lung

  • Carcinoma Non-Small Cell Lung

  • Carcinoma, Non-Small-Cell Lung

  • Lung Cancers

  • Lung Carcinomas

  • Cancer, Lung

  • Cancer, Lung, Non-Small Cell

  • Primary Malignant Neoplasm Of Lung

  • Bronchioloalveolar Adenocarcinoma
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS01990 CAVIN3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21833 Cavin3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta CAVIN3 VGNC VGNC:70693
Rattus norvegicus CAVIN3 RGD RGD:628755
Mus musculus CAVIN3 MGD MGI:1923422
Bos taurus CAVIN3 VGNC VGNC:26804
Felis catus CAVIN3 VGNC VGNC:81912
Canis familiaris CAVIN3 VGNC VGNC:38755
Others CAVIN3 NCBI