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PRAP1 - proline rich acidic protein 1 Gene

Also Known as UPA; PRO1195

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 118471

About PRAP1

Cytogenetic location: 10q26.3 Genomic coordinates (GRCh38): 10:133,347,373-133,352,683 (from NCBI)

This gene has 2 transcripts (splice variants) and 70 orthologues. Biased expression in small intestine (RPKM 388.5), duodenum (RPKM 348.9) and 3 other tissues.

Summary

Predicted to enable triglyceride binding activity. Involved in DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; deactivation of mitotic spindle assembly checkpoint; and negative regulation of apoptotic process. Predicted to be located in endoplasmic reticulum and extracellular region. [provided by Alliance of Genome Resources, Apr 2022]

PRAP1 Products (2)

mRNA	Protein	Name
NM_001145201.2	NP_001138673.1	proline-rich acidic protein 1 isoform 2 precursor
NM_145202.5	NP_660203.3	proline-rich acidic protein 1 isoform 1 precursor

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	24374861	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in DNA damage response	IDA IDA: Inferred from direct assay	23235459	GOA
involved in DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	IMP IMP: Inferred from mutant phenotype	23235459	GOA
involved in deactivation of mitotic spindle assembly checkpoint	IDA IDA: Inferred from direct assay	24374861	GOA
involved in negative regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	23235459	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PRAP1 Protein Structure

PRAP

0
100
151 a.a.

Protein Preferred Names	Protein Names
proline-rich acidic protein 1	epididymis secretory sperm binding protein

PRAP1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	PRAP1	Q96NZ9	UBQLN1	Homo sapiens	Q9UMX0-2	Y2H Prey Pooling	25416956
Intra	PRAP1	Q96NZ9	UBQLN1	Homo sapiens	Q9UMX0-2	Y2H Array	25416956
Intra	PRAP1	Q96NZ9	UBQLN1	Homo sapiens	Q9UMX0-2	Validated Y2H	25416956
Intra	PRAP1	Q96NZ9	MEOX2	Homo sapiens	Q6FHY5	Y2H Array	32296183
Intra	PRAP1	Q96NZ9	MEOX2	Homo sapiens	Q6FHY5	Y2H Prey Pooling	32296183
Intra	PRAP1	Q96NZ9	SGTA	Homo sapiens	O43765	Y2H Prey Pooling	32296183
Intra	PRAP1	Q96NZ9	SGTA	Homo sapiens	O43765	Y2H Prey Pooling	25416956
Intra	PRAP1	Q96NZ9	SGTA	Homo sapiens	O43765	Y2H Array	32296183
Intra	PRAP1	Q96NZ9	HSPA6	Homo sapiens	P17066	Y2H Prey Pooling	32296183
Intra	PRAP1	Q96NZ9	HSPA6	Homo sapiens	P17066	Y2H Array	32296183
Intra	PRAP1	Q96NZ9	UBQLN1	Homo sapiens	Q9UMX0	Y2H Prey Pooling	32296183
Intra	PRAP1	Q96NZ9	UBQLN1	Homo sapiens	Q9UMX0	Validated Y2H	32296183
Intra	PRAP1	Q96NZ9	UBQLN1	Homo sapiens	Q9UMX0	Y2H Array	25416956
Intra	PRAP1	Q96NZ9	UBQLN1	Homo sapiens	Q9UMX0	Y2H Array	32296183
Intra	PRAP1	Q96NZ9	UBQLN2	Homo sapiens	Q9UHD9	Y2H Prey Pooling	32296183
Intra	PRAP1	Q96NZ9	UBQLN2	Homo sapiens	Q9UHD9	Validated Y2H	32296183
Intra	PRAP1	Q96NZ9	UBQLN2	Homo sapiens	Q9UHD9	Y2H Array	32296183
Intra	PRAP1	Q96NZ9	MRFAP1	Homo sapiens	Q9Y605	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant PRAP1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71004	PRAP1 Protein, Human (HEK293, His)	AAL16670.1 (V21-Q151)	≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases	Alias
Hepatocellular Carcinoma	Liver Cancer Primary Liver Cancer HCC Hepatoma Malignant Neoplasm Of Liver Liver Neoplasms Cancer, Hepatocellular Liver Cell Carcinoma Lcc Hepatoblastoma, Somatic Hepatic Cancer Primary Malignant Neoplasm Of Liver Rare Tumor Of Liver And Intrahepatic Biliary Tract Hepatocellular Carcinoma, Somatic Hepatocellular Carcinoma, Childhood Type, Somatic Hepatocellular Cancer, Somatic Ca Liver - Primary Hepatic Neoplasm Malignant Hepato-Biliary Neoplasm Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary Malignant Neoplasm Of Liver, Primary Malignant Tumor Of Liver Neoplasm Of Liver Non-Resectable Primary Hepatic Malignant Neoplasm Resectable Malignant Neoplasm Of Liver Resectable Malignant Neoplasm Of The Liver Primary Liver Carcinoma Primary Malignant Liver Neoplasm Primary Cancer Of Liver Primary Tumor Of The Liver Rare Tumor Of Liver And Ibt Hepatocellular Cancer Neoplasm Of The Liver Carcinoma, Hepatocellular Hepatomas Liver Neoplasm Liver Carcinoma Liver And Intrahepatic Biliary Tract Carcinoma Malignant Hepatobiliary Neoplasm Adult Primary Hepatocellular Carcinoma Hepatoblastoma Carcinoma Of Liver Malignant Liver Tumour Malignant Hepatic Tumour

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11050	PRAP1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19028	Prap1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25517	Prap1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	PRAP1	RGD	RGD:61876
Canis familiaris	PRAP1	VGNC	VGNC:53010
Mus musculus	PRAP1	MGD	MGI:893573
Bos taurus	PRAP1	VGNC	VGNC:55965