HspA2 Antibody (YA3056)

Cat. No.: HY-P83311: Data Sheet COA
SDS
User Guide for Antibodies
FAQs
Technical Support

HspA2 Antibody (YA3056) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to HspA2.

For research use only. We do not sell to patients.

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10 μL	In-stock	Estimated Time of Arrival: December 31
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HspA2 Antibody (YA3056) Featured Recommendations:

1 Publications Citing Use of MCE HspA2 Antibody (YA3056)

•J Renin Angiotensin Aldosterone Syst. 2025 Dec 3.

WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Verification Image
Background
Documentation
References

Description

HspA2 Antibody (YA3056) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to HspA2.

Host

Rabbit

Clonality

Recombinant, Monoclonal

Molecular Weight

Predicted band size: 70 kDa;

Observed band size: 70 kDa

Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.

Species Reactivity

Human, Mouse, Rat

SwissProt ID

P54652

Gene ID

3306 [NCBI]

Immunogen

Recombinant protein of human HSPA2 aa488-637.

Application &
Dilution Ratio

Application	Dilution Ratio
WB WB: Western Blot	1:500-1:1000
IHC-P IHC-P: Immunohistochemistry-Paraffin	1:50-1:100

Sensitivity	Endogenous	Purity	Affinity Purified
Conjugation	Non-conjugated	Modification	Unmodified
Isotype	IgG

Appearance

Liquid

Formulation

Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping

Shipping with blue ice.

Verification Image

Western blot analysis of extracts from HeLa (lane 2(20μg)), C6 (lane 3(20μg)) and 3T3 (lane 4(20μg)) using HSPA2 Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (beta Actin, HY-P83730, 1/5000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Rabbit/Mouse IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

Background

Function：Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The affinity for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. It goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release (PubMed:26865365). Plays a role in spermatogenesis. In association with SHCBP1L may participate in the maintenance of spindle integrity during meiosis in male germ cells (By similarity)

Subcellular Localization：Cytoplasm, cytoskeleton, spindle

Subunit：Interacts with FKBP6 (PubMed:18529014). Interacts with ZNF541. Component of the CatSper complex. Interacts with RABL2/RABL2A; binds preferentially to GTP-bound RABL2. Interacts with SHCBP1L; this interaction may promote the recruitment of HSPA2 to the spindle (By similarity)

RRID

AB_3105424

Database

Entrez Gene: 3306 Human ; 15512 Mouse ; 60460 Rat

SwissProt: P54652 Human ; P17156 Mouse ; P14659 Rat

OMIM: 140560 Human

Research Field

Signal Transduction

Synonyms

HSPA2; Heat shock 70kD protein 2; HSP70-2; HSP70-3; Heat shock 70 kDa protein 2; Heat shock 70kDa protein 2

Documentation

Select Batch:

Data Sheet (231 KB) SDS (251 KB)

COA (206 KB)

User Guide for Antibodies (1077 KB)

References

[1]. /biology-dictionary/molt-4-cell.html [Content Brief]

HspA2 Antibody (YA3056) Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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HspA2 Antibody (YA3056)

HspA2 Antibody (YA3056) Featured Recommendations:

1 Publications Citing Use of MCE HspA2 Antibody (YA3056)

Product Detail

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Background

Documentation

References

HspA2 Antibody (YA3056) Related Classifications

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