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HSPBP1 - HSPA (Hsp70) binding protein 1 Gene

Also Known as FES1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 23640

About HSPBP1

Cytogenetic location: 19q13.42 Genomic coordinates (GRCh38): 19:55,262,223-55,280,383 (from NCBI)

This gene has 9 transcripts (splice variants), 185 orthologues and 1 paralogue. Ubiquitous expression in brain (RPKM 7.8), kidney (RPKM 7.4) and 25 other tissues.

Summary

Enables ubiquitin protein Ligase binding activity. Involved in positive regulation of proteasomal ubiquitin-dependent protein catabolic process and positive regulation of protein ubiquitination. Predicted to be active in endoplasmic reticulum. [provided by Alliance of Genome Resources, Apr 2022]

HSPBP1 Products (3)

mRNA	Protein	Name
NM_001130106.2	NP_001123578.1	hsp70-binding protein 1 isoform 2
NM_001297600.2	NP_001284529.1	hsp70-binding protein 1 isoform 1
NM_012267.5	NP_036399.3	hsp70-binding protein 1 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables molecular sequestering activity	IDA IDA: Inferred from direct assay	21247889	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16169070	GOA
enables ubiquitin protein ligase binding	IPI IPI: Inferred from physical interaction	16207813	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in positive regulation of proteasomal ubiquitin-dependent protein catabolic process	IDA IDA: Inferred from direct assay	16831871	GOA
involved in positive regulation of protein ubiquitination	IDA IDA: Inferred from direct assay	16831871	GOA

Cellular Component GO Annotation	Evidence	References	Source
is active in extracellular space	IDA IDA: Inferred from direct assay	16827227	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
hsp70-binding protein 1	HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1

HSPBP1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	HSPBP1	Q9NZL4	HSPA8	Homo sapiens	Q96IS6	Y2H Array	25416956
Intra	HSPBP1	Q9NZL4	HSPA8	Homo sapiens	Q96IS6	Validated Y2H	25416956
Intra	HSPBP1	Q9NZL4	HSPA8	Homo sapiens	P11142	Y2H Pooling	16189514
Intra	HSPBP1	Q9NZL4	HSPA8	Homo sapiens	P11142	Y2H Pooling	16169070
Intra	HSPBP1	Q9NZL4	HSPA8	Homo sapiens	P11142	Y2H Array	25416956
Intra	HSPBP1	Q9NZL4	HSPA8	Homo sapiens	P11142	Anti Tag CoIP	33961781
Intra	HSPBP1	Q9NZL4	HSPA2	Homo sapiens	P54652	Anti Tag CoIP	33961781
Intra	HSPBP1	Q9NZL4	HSPA2	Homo sapiens	P54652	Anti Tag CoIP	35271311
Intra	HSPBP1	Q9NZL4	HSPA2	Homo sapiens	P54652	Y2H Prey Pooling	25416956
Intra	HSPBP1	Q9NZL4	HSPA2	Homo sapiens	P54652	Y2H Array	16713569
Intra	HSPBP1	Q9NZL4	HSPA2	Homo sapiens	P54652	Y2H Array	25416956
Intra	HSPBP1	Q9NZL4	HSPA2	Homo sapiens	P54652	Anti Tag CoIP	28514442
Intra	HSPBP1	Q9NZL4	ELF1	Homo sapiens	P32519	Anti Tag CoIP	33961781
Intra	HSPBP1	Q9NZL4	NOTCH2NLA	Homo sapiens	Q7Z3S9	Y2H Array	31515488
Intra	HSPBP1	Q9NZL4	NOTCH2NLA	Homo sapiens	Q7Z3S9	Y2H Prey Pooling	25416956
Intra	HSPBP1	Q9NZL4	NOTCH2NLA	Homo sapiens	Q7Z3S9	Validated Y2H	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Spinocerebellar Ataxia, Autosomal Recessive 16	Autosomal Recessive Spinocerebellar Ataxia 16 SCAR16 Autosomal Recessive Cerebellar Ataxia Due To Stub1 Deficiency Spinocerebellar Ataxia Autosomal Recessive Type 16 Spinocerebellar Ataxia, Autosomal Recessive, 16 Ataxia, Spinocerebellar, Autosomal Recessive, Type 16
Parkinson Disease, Late-Onset	Parkinson Disease Parkinson'S Disease PD PARK Parkinson Disease, Susceptibility To Late Onset Parkinson'S Disease Late Onset Parkinson Disease Paralysis Agitans Primary Parkinsonism Idiopathic Parkinson Disease Parkinson'S Parkinson Disease, Late-Onset, Susceptibility To Parkinson Disease, Age Of Onset, Modifier Lewy Body Parkinson Disease Idiopathic Parkinson'S Disease Pd - [Parkinson Disease] Parkinson Disease Nos Parkinson, Nos Primary Parkinson Disease

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06446	HSPBP1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	HSPBP1	MGD	MGI:1913495
Rattus norvegicus	HSPBP1	RGD	RGD:628677
Canis familiaris	HSPBP1	VGNC	VGNC:53527
Others	HSPBP1	NCBI