HSPBP1 - HSPA (Hsp70) binding protein 1 Gene

Homo sapiens

Also known as FES1

Gene ID: 23640 | Gene type: protein coding

About HSPBP1

Cytogenetic location: 19q13.42 Genomic coordinates (GRCh38): 19:55,262,223-55,280,383 (from NCBI)

This gene has 9 transcripts (splice variants), 185 orthologues and 1 paralogue. Ubiquitous expression in brain (RPKM 7.8), kidney (RPKM 7.4) and 25 other tissues.

Summary

Enables ubiquitin protein ligase binding activity. Involved in positive regulation of proteasomal ubiquitin-dependent protein catabolic process and positive regulation of protein ubiquitination. Predicted to be active in endoplasmic reticulum. [provided by Alliance of Genome Resources, Apr 2022]

HSPBP1 Products(3)

mRNA	Protein	Name
NM_001130106.2	NP_001123578.1	hsp70-binding protein 1 isoform 2
NM_001297600.2	NP_001284529.1	hsp70-binding protein 1 isoform 1
NM_012267.5	NP_036399.3	hsp70-binding protein 1 isoform 2

Protein Preferred Names

Protein Names

hsp70-binding protein 1

HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1

Related Diseases

Diseases

Alias

Spinocerebellar Ataxia, Autosomal Recessive 16

Autosomal Recessive Spinocerebellar Ataxia 16	SCAR16
Autosomal Recessive Cerebellar Ataxia Due To Stub1 Deficiency	Spinocerebellar Ataxia Autosomal Recessive Type 16
Spinocerebellar Ataxia, Autosomal Recessive, 16	Ataxia, Spinocerebellar, Autosomal Recessive, Type 16

Parkinson Disease, Late-Onset

Parkinson Disease	Parkinson'S Disease
PD	PARK
Parkinson Disease, Susceptibility To	Late Onset Parkinson'S Disease
Late Onset Parkinson Disease	Paralysis Agitans
Primary Parkinsonism	Idiopathic Parkinson Disease
Parkinson'S	Parkinson Disease, Late-Onset, Susceptibility To
Parkinson Disease, Age Of Onset, Modifier	Lewy Body Parkinson Disease
Idiopathic Parkinson'S Disease	Pd - [Parkinson Disease]
Parkinson Disease Nos	Parkinson, Nos
Primary Parkinson Disease

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06446	HSPBP1 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	HSPBP1	MGD	MGI:1913495
Rattus norvegicus	HSPBP1	RGD	RGD:628677
Canis familiaris	HSPBP1	VGNC	VGNC:53527
Others	HSPBP1	NCBI

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