ELF1 - E74 like ETS transcription factor 1 Gene

Also Known as RIA1; EFTUD1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 1997

About ELF1

Cytogenetic location: 13q14.11 Genomic coordinates (GRCh38): 13:40,931,919-41,061,386 (from NCBI)

This gene has 5 transcripts (splice variants), 194 orthologues and 28 paralogues. Ubiquitous expression in bone marrow (RPKM 46.7), lymph node (RPKM 34.5) and 25 other tissues.

Summary

This gene encodes an E26 transformation-specific related transcription factor. The encoded protein is primarily expressed in lymphoid cells and acts as both an enhancer and a repressor to regulate transcription of various genes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2009]

ELF1 Products (6)

mRNA Protein Name
NM_001145353.1 NP_001138825.1 ETS-related transcription factor Elf-1 isoform b
NM_001370329.1 NP_001357258.1 ETS-related transcription factor Elf-1 isoform c
NM_001370330.1 NP_001357259.1 ETS-related transcription factor Elf-1 isoform a
NM_001370331.1 NP_001357260.1 ETS-related transcription factor Elf-1 isoform a
NM_001370332.1 NP_001357261.1 ETS-related transcription factor Elf-1 isoform a
NM_172373.4 NP_758961.1 ETS-related transcription factor Elf-1 isoform a

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
8756667 GOA
enables DNA-binding transcription factor activity IDA
IDA: Inferred from direct assay
14970218 GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
8756667 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
10207087 GOA
enables sequence-specific double-stranded DNA binding IDA
IDA: Inferred from direct assay
28473536 GOA
Biological Process GO Annotation Evidence References Source
involved in positive regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
19674970 GOA
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
8756667 GOA
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
19674970 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ELF1 Protein Structure

Elf-1_N

Elf-1_N: Transcription factor protein N terminal (1 - 111)

Ets

Ets: Ets-domain (208 - 291)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 619 a.a.
Protein Preferred Names Protein Names

ETS-related transcription factor Elf-1

  • E74-like factor 1 (ets domain transcription factor)

ELF1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
ELF1 P32519 NFYC Homo sapiens Q13952-2
Validated Y2H
32296183
Intra
ELF1 P32519 HOXC13 Homo sapiens P31276
Pull Down
18692240
Intra
ELF1 P32519 HOXC13 Homo sapiens P31276
Anti Tag CoIP
18692240
Intra
ELF1 P32519 SP1 Homo sapiens P08047
Pull Down
10976766
Intra
ELF1 P32519 HSPBP1 Homo sapiens Q9NZL4
Anti Tag CoIP
28514442
Cross: Cross-species interaction Intra: Intraspecies interaction

ELF1 Antibodies

Cat. No. Product Name Application Reactivity
HY-P811109 ELF1 Antibody WB, IHC-P, ICC/IF Human, Mouse

Related Diseases

Diseases Alias
Retinoblastoma

  • RB

  • Trilateral Retinoblastoma

  • RB1

  • Retinoblastoma, Trilateral

  • Neuroblastoma Of Retina

  • Rb - Retinoblastoma

  • Eye Cancer, Retinoblastoma

  • Retinal Cancer

  • Retinal Tumor

  • Glioma, Retinal

  • Non-Hereditary Retinoblastoma

  • Childhood Cancer Retinoblastoma

  • Malignant Neoplasm Of Retina

  • Retinal Neoplasms
Intramuscular Hemangioma

  • Intramuscular Angioma

  • Hemangioma Intramuscular

  • Hemangioma, Intramuscular
Systemic Lupus Erythematosus

  • Lupus Nephritis

  • SLE

  • Disseminated Lupus Erythematosus

  • Systemic Lupus Erythematosus, Susceptibility To

  • Lupus Erythematosus, Systemic

  • Lupus Nephritis, Susceptibility To

  • Libman-Sacks Disease

  • Systemic Lupus Erythematosus Susceptibility To

  • Sle - Lupus Erythematosus, Systemic

  • Le Syndrome

  • Lupus

  • Lupus Erythematosus Systemic

  • Lupus Erythematosus, Systemic, Susceptibility To

  • Lupus Vulgaris

  • Lupus Erythematosus, Discoid

  • Lupus Erythematosus

  • Systemic Lupus Erythematosus Nos

  • Sle - [Systemic Lupus Erythematosus]
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (7)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS04193 EFNA2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS04298 ELF1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS04320 ELOF1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17828 Efna2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19817 Sptbn1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21333 Elf1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27852 Elf1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus ELF1 VGNC VGNC:28426
Felis catus ELF1 VGNC VGNC:61805
Canis familiaris ELF1 VGNC VGNC:40298
Rattus norvegicus ELF1 RGD RGD:620697
Macaca mulatta ELF1 VGNC VGNC:72205
Mus musculus ELF1 MGD MGI:107180
Others ELF1 NCBI