SOCS6 - suppressor of cytokine signaling 6 Gene

Also Known as CIS4; SSI4; CIS-4; SOCS4; STAI4; SOCS-4; SOCS-6; STATI4; HSPC060

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 9306

About SOCS6

Cytogenetic location: 18q22.2 Genomic coordinates (GRCh38): 18:70,289,045-70,330,199 (from NCBI)

This gene has 3 transcripts (splice variants), 226 orthologues and 7 paralogues. Ubiquitous expression in small intestine (RPKM 4.2), colon (RPKM 3.9) and 25 other tissues.

Summary

The protein encoded by this gene contains a SH2 domain and a CIS homolog domain. The protein thus belongs to the cytokine-induced STAT Inhibitor (CIS), also known as suppressor of cytokine signaling (SOCS) or STAT-induced STAT Inhibitor (SSI), protein family. CIS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by GM-CSF and EPO in hematopoietic cells. A high expression level of this gene was found in factor-independent chronic myelogenous leukemia (CML) and erythroleukemia (HEL) cell lines. [provided by RefSeq, Jul 2008]

SOCS6 Products (1)

mRNA Protein Name
NM_004232.4 NP_004223.2 suppressor of cytokine signaling 6

SOCS6 Protein Structure

SH2

SH2: SH2 domain (384 - 460)

SOCS_box

SOCS_box: SOCS box (497 - 531)

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  • 500
  • 535 a.a.
Protein Preferred Names Protein Names

suppressor of cytokine signaling 6

  • STAT induced STAT inhibitor-4

SOCS6 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
SOCS6 O14544 MET Homo sapiens P08581
FPS
24728074
Intra
SOCS6 O14544 YAP1 Homo sapiens P46937
Anti Bait CoIP
25180228
Intra
SOCS6 O14544 YAP1 Homo sapiens P46937
Anti Tag CoIP
25180228
Intra
SOCS6 O14544 KIT Homo sapiens P10721
FPS
24728074
Intra
SOCS6 O14544 ERN1 Homo sapiens O75460-2
Y2H Array
32814053
Intra
SOCS6 O14544 ERN1 Homo sapiens O75460-2
Validated Y2H
32814053
Intra
SOCS6 O14544 ERN1 Homo sapiens O75460-2
Y2H Pooling
32814053
Intra
SOCS6 O14544 FGFR3 Homo sapiens P22607
Validated Y2H
32814053
Intra
SOCS6 O14544 FGFR3 Homo sapiens P22607
Y2H Array
32814053
Intra
SOCS6 O14544 FGFR3 Homo sapiens P22607
Y2H Pooling
32814053
Intra
SOCS6 O14544 GSN Homo sapiens P06396
Y2H Array
32814053
Intra
SOCS6 O14544 GSN Homo sapiens P06396
Y2H Pooling
32814053
Intra
SOCS6 O14544 GSN Homo sapiens P06396
Validated Y2H
32814053
Intra
SOCS6 O14544 TARDBP Homo sapiens Q13148
Y2H Array
32814053
Intra
SOCS6 O14544 TARDBP Homo sapiens Q13148
Y2H Pooling
32814053
Intra
SOCS6 O14544 TARDBP Homo sapiens Q13148
Validated Y2H
32814053
Intra
SOCS6 O14544 GAB1 Homo sapiens Q13480
FPS
24728074
Intra
SOCS6 O14544 AR Homo sapiens P10275
FPS
24728074
Intra
SOCS6 O14544 ARIH2 Homo sapiens O95376
Anti Tag CoIP
33961781
Intra
SOCS6 O14544 ARIH2 Homo sapiens O95376
Anti Tag CoIP
28514442
Intra
SOCS6 O14544 TXK Homo sapiens P42681
Validated Y2H
32296183
Intra
SOCS6 O14544 AIRIM Homo sapiens Q9NX04
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Somatization Disorder

  • Somatoform Disorders

  • Briquet'S Disorder

  • Polysomatising Disorder

  • Somatisation Disorder

  • Somatoform Disorder
Articulation Disorder

  • Phonological Disorder

  • Articulation Disorders

  • Articulation Impairment

  • Speech Sound Disorders
Speech Disorder

  • Speech Disorders
Stuttering

  • Stammering

  • Familial Persistent Stuttering

  • Stuttering, Familial Persistent 1
Myelofibrosis

  • Primary Myelofibrosis

  • Agnogenic Myeloid Metaplasia

  • Idiopathic Myelofibrosis

  • Myeloid Metaplasia

  • Myelofibrosis With Myeloid Metaplasia

  • Osteomyelofibrosis

  • Megakaryocytic Myelosclerosis

  • Myelosclerosis

  • Chronic Idiopathic Myelofibrosis

  • Myelofibrosis, Idiopathic

  • Myelofibrosis With Myeloid Metaplasia, Somatic

  • Myelofibrosis, Somatic

  • Aleukemic Myelosis

  • Bone Marrow Fibrosis

  • MYELOF

  • MMM

  • Agnogenic Myeloid Metaplasia With Myelofibrosis

  • Ammm

  • Myelosclerosis With Myeloid Metaplasia

  • Myelofibrosis Nos
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-156395 MN551 Inducer 98.01% Unkown
HY-RS13557 SOCS6 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta SOCS6 VGNC VGNC:81577
Bos taurus SOCS6 VGNC VGNC:35124
Mus musculus SOCS6 MGD MGI:1924885
Canis familiaris SOCS6 VGNC VGNC:56921
Rattus norvegicus SOCS6 RGD RGD:1304632
Felis catus SOCS6 VGNC VGNC:65565
Others SOCS6 NCBI