CHMP7 - charged multivesicular body protein 7 Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 91782

About CHMP7

Cytogenetic location: 8p21.3 Genomic coordinates (GRCh38): 8:23,243,637-23,261,999 (from NCBI)

This gene has 10 transcripts (splice variants), 203 orthologues and 4 paralogues. Ubiquitous expression in lymph node (RPKM 21.0), appendix (RPKM 14.0) and 25 other tissues.

Summary

Involved in several processes, including late endosome to vacuole transport; midbody abscission; and mitotic nuclear division. Located in cytosol; nuclear envelope; and nucleoplasm. Part of ESCRT III complex. Colocalizes with chromatin. [provided by Alliance of Genome Resources, Apr 2022]

CHMP7 Products (3)

mRNA Protein Name
NM_001317899.2 NP_001304828.1 charged multivesicular body protein 7 isoform 2
NM_001363183.2 NP_001350112.1 charged multivesicular body protein 7 isoform 3
NM_152272.5 NP_689485.1 charged multivesicular body protein 7 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
16856878 GOA
Biological Process GO Annotation Evidence References Source
involved in autophagosome maturation IMP
IMP: Inferred from mutant phenotype
17984323 GOA
involved in autophagy IMP
IMP: Inferred from mutant phenotype
17984323 GOA
involved in exit from mitosis IMP
IMP: Inferred from mutant phenotype
26040712 GOA
involved in late endosome to lysosome transport IMP
IMP: Inferred from mutant phenotype
17984323 GOA
involved in late endosome to vacuole transport IMP
IMP: Inferred from mutant phenotype
16856878 GOA
involved in midbody abscission IMP
IMP: Inferred from mutant phenotype
20616062 GOA
involved in mitotic metaphase chromosome alignment IMP
IMP: Inferred from mutant phenotype
20616062 GOA
involved in multivesicular body sorting pathway IDA
IDA: Inferred from direct assay
16554368 GOA
involved in nuclear membrane reassembly IMP
IMP: Inferred from mutant phenotype
26040712 GOA
involved in nucleus organization IMP
IMP: Inferred from mutant phenotype
20616062 GOA
involved in plasma membrane repair IDA
IDA: Inferred from direct assay
24482116 GOA
involved in protein localization to chromatin IMP
IMP: Inferred from mutant phenotype
28242692 GOA
involved in regulation of mitotic spindle assembly IMP
IMP: Inferred from mutant phenotype
20616062 GOA
involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway IDA
IDA: Inferred from direct assay
17984323 GOA
involved in viral budding from plasma membrane IDA
IDA: Inferred from direct assay
24878737 GOA
involved in viral budding via host ESCRT complex IDA
IDA: Inferred from direct assay
24878737 GOA
Cellular Component GO Annotation Evidence References Source
part of ESCRT III complex IDA
IDA: Inferred from direct assay
16856878 GOA
located in amphisome membrane IDA
IDA: Inferred from direct assay
17984323 GOA
located in autophagosome membrane IDA
IDA: Inferred from direct assay
17984323 GOA
located in chromatin IDA
IDA: Inferred from direct assay
28242692 GOA
located in kinetochore IDA
IDA: Inferred from direct assay
26040712 GOA
located in kinetochore microtubule IDA
IDA: Inferred from direct assay
26040712 GOA
located in lysosomal membrane IDA
IDA: Inferred from direct assay
17984323 GOA
located in midbody IDA
IDA: Inferred from direct assay
26040712 GOA
located in multivesicular body membrane IDA
IDA: Inferred from direct assay
16554368 GOA
located in nuclear envelope IDA
IDA: Inferred from direct assay
26040712 GOA
part of nuclear pore IDA
IDA: Inferred from direct assay
26040713 GOA
located in plasma membrane IDA
IDA: Inferred from direct assay
24878737 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CHMP7 Protein Structure

Snf7

Snf7: Snf7 (243 - 404)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 453 a.a.
Protein Preferred Names Protein Names

charged multivesicular body protein 7

  • CHMP family, member 7

CHMP7 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
CHMP7 Q8WUX9 FGFR3 Homo sapiens P22607
Validated Y2H
32814053
Intra
CHMP7 Q8WUX9 FGFR3 Homo sapiens P22607
Y2H Pooling
32814053
Intra
CHMP7 Q8WUX9 FGFR3 Homo sapiens P22607
Y2H Array
32814053
Intra
CHMP7 Q8WUX9 HRAS Homo sapiens P01112
Y2H Pooling
32814053
Intra
CHMP7 Q8WUX9 HRAS Homo sapiens P01112
Validated Y2H
32814053
Intra
CHMP7 Q8WUX9 HRAS Homo sapiens P01112
Y2H Array
32814053
Intra
CHMP7 Q8WUX9 GSN Homo sapiens P06396
Y2H Array
32814053
Intra
CHMP7 Q8WUX9 GSN Homo sapiens P06396
Validated Y2H
32814053
Intra
CHMP7 Q8WUX9 GSN Homo sapiens P06396
Y2H Pooling
32814053
Intra
CHMP7 Q8WUX9 PMP22 Homo sapiens A0A6Q8PF08
Validated Y2H
32814053
Intra
CHMP7 Q8WUX9 PMP22 Homo sapiens A0A6Q8PF08
Y2H Array
32814053
Intra
CHMP7 Q8WUX9 PMP22 Homo sapiens A0A6Q8PF08
Y2H Pooling
32814053
Intra
CHMP7 Q8WUX9 SPRED1 Homo sapiens Q7Z699
Validated Y2H
32814053
Intra
CHMP7 Q8WUX9 SPRED1 Homo sapiens Q7Z699
Y2H Pooling
32814053
Intra
CHMP7 Q8WUX9 SPRED1 Homo sapiens Q7Z699
Y2H Array
32814053
Intra
CHMP7 Q8WUX9 CHMP4B Homo sapiens Q9H444
Y2H
16856878
Intra
CHMP7 Q8WUX9 CHMP4B Homo sapiens Q9H444
Pull Down
16856878
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS02648 CHMP7 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus CHMP7 VGNC VGNC:60866
Rattus norvegicus CHMP7 RGD RGD:1308779
Bos taurus CHMP7 VGNC VGNC:27306
Mus musculus CHMP7 MGD MGI:1913922
Canis familiaris CHMP7 VGNC VGNC:54933
Macaca mulatta CHMP7 VGNC VGNC:71122
Others CHMP7 NCBI