2. Apoptosis
  3. Survivin
  4. LLP-3

LLP-3 is a potent Survivin inhibitor that disrupts the Survivin-Ran interaction in cancer cells. LLP-3 can be used in the research of Glioblastoma multiforme (GBM).

For research use only. We do not sell to patients.

LLP-3 Chemical Structure

LLP-3 Chemical Structure

CAS No. : 1453835-43-2

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Based on 1 publication(s) in Google Scholar

LLP-3 Related Antibodies

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Description

LLP-3 is a potent Survivin inhibitor that disrupts the Survivin-Ran interaction in cancer cells. LLP-3 can be used in the research of Glioblastoma multiforme (GBM)[1].

IC50 & Target

Survivin[1]
In Vitro

LLP-3 (20 μM, 24 h) impaires the binding of Survivin to Smac/DIABLO (proapoptotic protein), without affecting the interaction of Survivin with other chromosomal passenger complex (CPC) proteins[1].
LLP-3 (20 μM, 24 h) decreases the Survivin-Ran interaction in U87 cells[1].
LLP-3 (20 μM, 24 h) arrests cell in G0-G1 phase and subsequent tumor cell death[1].
LLP-3 (20 μM, 24 h) triggers caspase-dependent apoptosis in HT1080 cells[1].
LLP-3 (0-100 μM, 72 h) inhibits tumor cells survival by p53-mediated inhibition[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

LLP-3 Related Antibodies

Cell Viability Assay[1]

Cell Line: U87E6, U87MG cell
Concentration: 0-100 μM
Incubation Time: 72 h
Result: Inhibited tumor cells survival with IC50 values of 13.6 μM (U87E6) and 38.1 μM (U87MG).

Cell Cycle Analysis[1]

Cell Line: U87 cells
Concentration: 20 μM
Incubation Time: 24 h
Result: Reduced the proportions of cells in the S and G2-M phases (from 9% to 5%, and from 25% to 17%, respectively).
Increased G0-G1 cell population (from 60% to 74%).

Immunofluorescence[1]

Cell Line: U87, HT1080 cells
Concentration: 40 μM
Incubation Time: 24 h
Result: Weakened the colocalization of TPX2 with the acetylated α-tubulin.
In Vivo

LLP-3 (intraperitoneal injection, 25 mg/kg, for 10 days) prolongs survival of GBM sphere-derived tumor mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: GBM sphere-derived tumor models (GBM83 and 1600)[1]
Dosage: 25 mg/kg
Administration: Intraperitoneal injection, for 10 days (days 10–14 and days 17–21)
Result: Prolonged the survival of tumor-burden mice without exhibiting any lethality of mice until day 35.
Molecular Weight

534.99

Formula

C32H23ClN2O4
CAS No.
SMILES

N#CC1=C(C2=CC(OCC3=CC=CC=C3)=CC(OCC4=CC=CC=C4)=C2)C=C(C5=CC(Cl)=CC=C5O)NC1=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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LLP-3 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

LLP-31453835-43-2LLP3LLP 3SurvivinGlioblastoma multiformeGBMcancerU87 cellsSurvivin-RanHT1080Inhibitorinhibitorinhibit

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