2. Apoptosis
  3. Survivin
  4. LLP-3

LLP-3 is a potent Survivin inhibitor that disrupts the Survivin-Ran interaction in cancer cells. LLP-3 can be used in the research of Glioblastoma multiforme (GBM).

For research use only. We do not sell to patients.

LLP-3

LLP-3 Chemical Structure

CAS No. : 1453835-43-2

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Based on 1 publication(s) in Google Scholar

LLP-3 Related Antibodies

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  • Biological Activity

  • Purity & Documentation

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Description

LLP-3 is a potent Survivin inhibitor that disrupts the Survivin-Ran interaction in cancer cells. LLP-3 can be used in the research of Glioblastoma multiforme (GBM)[1].

IC50 & Target

Survivin[1]
Cellular Effect
Cell Line Type Value Description References
LN-229 IC50
31.2 μM
Compound: 10; LLP3
Antiproliferative activity against human LN-229 cells assessed as cell growth inhibition
Antiproliferative activity against human LN-229 cells assessed as cell growth inhibition
[PMID: 38092421]
In Vitro

LLP-3 (20 μM, 24 h) impaires the binding of Survivin to Smac/DIABLO (proapoptotic protein), without affecting the interaction of Survivin with other chromosomal passenger complex (CPC) proteins[1].
LLP-3 (20 μM, 24 h) decreases the Survivin-Ran interaction in U87 cells[1].
LLP-3 (20 μM, 24 h) arrests cell in G0-G1 phase and subsequent tumor cell death[1].
LLP-3 (20 μM, 24 h) triggers caspase-dependent apoptosis in HT1080 cells[1].
LLP-3 (0-100 μM, 72 h) inhibits tumor cells survival by p53-mediated inhibition[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

LLP-3 Related Antibodies

Cell Viability Assay[1]

Cell Line: U87E6, U87MG cell
Concentration: 0-100 μM
Incubation Time: 72 h
Result: Inhibited tumor cells survival with IC50 values of 13.6 μM (U87E6) and 38.1 μM (U87MG).

Cell Cycle Analysis[1]

Cell Line: U87 cells
Concentration: 20 μM
Incubation Time: 24 h
Result: Reduced the proportions of cells in the S and G2-M phases (from 9% to 5%, and from 25% to 17%, respectively).
Increased G0-G1 cell population (from 60% to 74%).

Immunofluorescence[1]

Cell Line: U87, HT1080 cells
Concentration: 40 μM
Incubation Time: 24 h
Result: Weakened the colocalization of TPX2 with the acetylated α-tubulin.
In Vivo

LLP-3 (intraperitoneal injection, 25 mg/kg, for 10 days) prolongs survival of GBM sphere-derived tumor mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: GBM sphere-derived tumor models (GBM83 and 1600)[1]
Dosage: 25 mg/kg
Administration: Intraperitoneal injection, for 10 days (days 10–14 and days 17–21)
Result: Prolonged the survival of tumor-burden mice without exhibiting any lethality of mice until day 35.
Molecular Weight

534.99

Formula

C32H23ClN2O4
CAS No.
Appearance

Solid

Color

White to light yellow

SMILES

N#CC1=C(C2=CC(OCC3=CC=CC=C3)=CC(OCC4=CC=CC=C4)=C2)C=C(C5=CC(Cl)=CC=C5O)NC1=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 12.5 mg/mL (23.36 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8692 mL 9.3460 mL 18.6919 mL
5 mM 0.3738 mL 1.8692 mL 3.7384 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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In Vivo Dissolution Calculator
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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.8692 mL 9.3460 mL 18.6919 mL 46.7298 mL
5 mM 0.3738 mL 1.8692 mL 3.7384 mL 9.3460 mL
10 mM 0.1869 mL 0.9346 mL 1.8692 mL 4.6730 mL
15 mM 0.1246 mL 0.6231 mL 1.2461 mL 3.1153 mL
20 mM 0.0935 mL 0.4673 mL 0.9346 mL 2.3365 mL
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LLP-3 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

LLP-31453835-43-2LLP3LLP 3SurvivinGlioblastoma multiformeGBMcancerU87 cellsSurvivin-RanHT1080Inhibitorinhibitorinhibit

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