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284451

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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-136794
    SB-284851-BT

    		p38 MAPK Epigenetic Reader Domain Inflammation/Immunology Cancer
    SB-284851-BT is an inhibitor of BRD4/p38α/BRDT. SB-284851-BT inhibits BRD4-BD1 (IC50=1.7 µM), p38α (Kd=0.47 nM), BRDT (1) (IC50=18 µM) and BRD4 (1)(IC50=3.7 µM). SB-284851-BT reduces IL-8 production by inhibiting p38α, as well as inhibiting BRD4 to down-regulates c-Myc and NF-κB gene pathways in cancer. SB-284851-BT can combined with the bromine domain and extra terminal (BET) .
    SB-284851-BT
  • HY-16275
    Nivocasan

    GS 9450; LB-84451

    		 Caspase Interleukin Related Inflammation/Immunology
    Nivocasan (GS 9450; LB-84451) is a pan-caspase inhibitor that irreversibly arrests caspase-1 activity and inhibits that of caspase-8. Nivocasan inhibits IL-1β cleavage and blocks osteoclast differentiation. Nivocasan inhibits the protein expression of NFATc1 and CSTK .
    Nivocasan

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