TNPO1 - transportin 1 Gene

Also Known as MIP; TRN; IPO2; MIP1; KPNB2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 3842

About TNPO1

Cytogenetic location: 5q13.2 Genomic coordinates (GRCh38): 5:72,816,661-72,914,388 (from NCBI)

This gene has 19 transcripts (splice variants), 215 orthologues and 5 paralogues. Ubiquitous expression in thyroid (RPKM 18.9), testis (RPKM 17.9) and 25 other tissues.

Summary

This gene encodes the beta subunit of the karyopherin receptor complex which interacts with nuclear localization signals to target nuclear proteins to the nucleus. The karyopherin receptor complex is a heterodimer of an alpha subunit which recognizes the nuclear localization signal and a beta subunit which docks the complex at nucleoporins. Alternate splicing of this gene results in several transcript variants encoding different proteins. [provided by RefSeq, Jun 2018]

TNPO1 Products (7)

mRNA Protein Name
NM_001364292.3 NP_001351221.1 transportin-1 isoform 2
NM_001364293.3 NP_001351222.1 transportin-1 isoform 2
NM_001364294.3 NP_001351223.1 transportin-1 isoform 3
NM_001364295.3 NP_001351224.1 transportin-1 isoform 4
NM_001364296.2 NP_001351225.1 transportin-1 isoform 5
NM_002270.4 NP_002261.3 transportin-1 isoform 1
NM_153188.4 NP_694858.1 transportin-1 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
10353245 GOA
Biological Process GO Annotation Evidence References Source
involved in protein import into nucleus IDA
IDA: Inferred from direct assay
9144189 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TNPO1 Protein Structure

IBN_N

IBN_N: Importin-beta N-terminal domain (42 - 108)

HEAT_EZ

HEAT_EZ: HEAT-like repeat (419 - 472)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 898 a.a.
Protein Preferred Names Protein Names

transportin-1

  • M9 region interaction protein

TNPO1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
TNPO1 Q92973 RAN Homo sapiens P62826
X-Ray Diffraction
10353245
Intra
TNPO1 Q92973 HNRNPA1 Homo sapiens P09651-2
Pull Down
17435768
Intra
TNPO1 Q92973 HNRNPA1 Homo sapiens P09651-2
ITC
17435768
Intra
TNPO1 Q92973 HNRNPM Homo sapiens P52272
Pull Down
17435768
Intra
TNPO1 Q92973 HNRNPM Homo sapiens P52272
ITC
17435768
Intra
TNPO1 Q92973 HNRNPM Homo sapiens P52272
X-Ray Diffraction
17435768
Intra
TNPO1 Q92973 HNRNPA0 Homo sapiens Q13151
Anti Tag CoIP
35271311
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Retinitis Pigmentosa 2

  • RP2

  • X-Linked Retinitis Pigmentosa 2

  • Xlrp2

  • Xlrp-2

  • Retinitis Pigmentosa-2

  • Retinitis Pigmentosa, Type 2
Multisystem Proteinopathy
Meningoencephalitis

  • Acquired Toxoplasmal Meningoencephalitis

  • Meningoencephalitis Due To Acquired Toxoplasmosis

  • Meningoencephalitis Due To Toxoplasmosis

  • Toxoplasma Meningoencephalitis
Epithelial-Stromal Tgfbi Dystrophy
Lattice Corneal Dystrophy

  • Familial Amyloid Neuropathy, Finnish Type

  • Familial Amyloid Polyneuropathy, Type V
Frontotemporal Dementia

  • Pallidopontonigral Degeneration

  • Frontotemporal Lobar Degeneration

  • Semantic Dementia

  • FTD

  • Frontotemporal Lobe Dementia

  • Multiple System Tauopathy With Presenile Dementia

  • Dementia, Frontotemporal

  • Frontotemporal Dementia With Parkinsonism

  • Mstd

  • Frontotemporal Lobar Degeneration With Tau Inclusions

  • Ftld With Tau Inclusions

  • Dementia, Frontotemporal, With Parkinsonism

  • Fldem

  • Ftdp17

  • Disinhibition-Dementia-Parkinsonism-Amyotrophy Complex

  • Ddpac

  • Wilhelmsen-Lynch Disease

  • Wld

  • Ppnd

  • Dementia, Frontotemporal, With Or Without Parkinsonism

  • Semantic Primary Progressive Aphasia

  • Semantic Variant Ppa

  • Wilhemsen-Lynch Disease

  • Frontotemporal Dementia-Amyotrophic Lateral Sclerosis

  • Frontotemporal Dementia And Parkinsonism Linked To Chromosome 17

  • Ftd-Als

  • Ftld

  • Pick Complex

  • Pick Disease Of The Brain

  • Frontotemporal Dementia With Parkinsonism-17

  • Grn-Related Frontotemporal Dementia

  • Frontotemporal Dementia With Motor Neuron Disease

  • Dementia In Fronto-Temporal Lobar Degeneration

  • Ftd - [Frontotemporal Dementia]

  • Temple Dementia

  • Frontal Lobe Dementia
Amyotrophic Lateral Sclerosis 1

  • Amyotrophic Lateral Sclerosis

  • ALS

  • Lou Gehrig Disease

  • Amyotrophic Lateral Sclerosis Type 1

  • Charcot Disease

  • ALS1

  • Amyotrophic Lateral Sclerosis, Susceptibility To

  • Fals

  • Lou Gehrig'S Disease

  • Mnd

  • Motor Neuron Disease

  • Familial Amyotrophic Lateral Sclerosis

  • Amyotrophic Lateral Sclerosis 1, Familial

  • Amyotrophic Lateral Sclerosis 1, Autosomal Dominant

  • Motor Neuron Disease, Bulbar

  • Motor Neurone Disease

  • Amyotrophic Lateral Sclerosis With Dementia

  • Dementia With Amyotrophic Lateral Sclerosis

  • Motor Neuron Disease, Amyotrophic Lateral Sclerosis

  • Sclerosis, Lateral, Amyotrophic

  • Sclerosis, Lateral, Amyotrophic, Type 1

  • Amyotrophic Sclerosis

  • Als - [Amyotrophic Lateral Sclerosis]

  • Wasting Palsy

  • Amyotrophic Paralysis

  • Amyotrophy Lateral Sclerosis

  • Wasting Paralysis

  • Spinal Progressive Amyotrophy

  • Progressive Atrophic Paralysis
Retinitis Pigmentosa

  • RP

  • Rod-Cone Dystrophy

  • Autosomal Recessive Retinitis Pigmentosa

  • Non-Syndromic Retinitis Pigmentosa

  • Pericentral Pigmentary Retinopathy

  • Pigmentary Retinopathy

  • Tapetoretinal Degeneration

  • Rcd

  • Retinitis Pigmentosa Autosomal Recessive

  • ARRP

  • Retinitis Pigmentosa, Autosomal Recessive

  • Retinitis Pigmentosa 1
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS14859 TNPO1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20118 Tnpo1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26622 Tnpo1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus TNPO1 RGD RGD:1308372
Felis catus TNPO1 VGNC VGNC:67980
Bos taurus TNPO1 VGNC VGNC:36199
Canis familiaris TNPO1 VGNC VGNC:47694
Macaca mulatta TNPO1 VGNC VGNC:79961
Mus musculus TNPO1 MGD MGI:2681523
Others TNPO1 NCBI