HAUS8 - HAUS augmin like complex subunit 8 Gene

Also Known as DGT4; HICE1; NY-SAR-48

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 93323

About HAUS8

Cytogenetic location: 19p13.11 Genomic coordinates (GRCh38): 19:17,049,729-17,075,533 (from NCBI)

This gene has 8 transcripts (splice variants) and 165 orthologues. Broad expression in testis (RPKM 8.8), lymph node (RPKM 7.3) and 24 other tissues.

Summary

HAUS8 is 1 of 8 subunits of the 390-kD human augmin complex, or HAUS complex. The augmin complex was first identified in Drosophila, and its name comes from the Latin verb 'augmentare,' meaning 'to increase.' The augmin complex is a microtubule-binding complex involved in microtubule generation within the mitotic spindle and is vital to mitotic spindle assembly (Goshima et al., 2008 [PubMed 18443220]; Uehara et al., 2009 [PubMed 19369198]).[supplied by OMIM, Jun 2010]

HAUS8 Products (2)

mRNA	Protein	Name
NM_001011699.1	NP_001011699.1	HAUS augmin-like complex subunit 8 isoform b
NM_033417.2	NP_219485.1	HAUS augmin-like complex subunit 8 isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	19369198	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in centrosome cycle	IMP IMP: Inferred from mutant phenotype	19427217	GOA
involved in spindle assembly	IMP IMP: Inferred from mutant phenotype	19369198	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of HAUS complex	IDA IDA: Inferred from direct assay	19369198	GOA
part of HAUS complex	IPI IPI: Inferred from physical interaction	20360068	GOA
located in centrosome	IDA IDA: Inferred from direct assay	21399614	GOA
located in mitotic spindle microtubule	IDA IDA: Inferred from direct assay	30723163	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
HAUS augmin-like complex subunit 8	HEC1/NDC80 interacting, centrosome associated 1

HAUS8 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	HAUS8	Q9BT25	NRDE2	Homo sapiens	Q9H7Z3	Validated Y2H	32296183
Intra	HAUS8	Q9BT25	HAUS6	Homo sapiens	Q7Z4H7	GMS	25173975
Intra	HAUS8	Q9BT25	HAUS6	Homo sapiens	Q7Z4H7	TAP	24981860
Intra	HAUS8	Q9BT25	HAUS6	Homo sapiens	Q7Z4H7	DLS	25173975
Intra	HAUS8	Q9BT25	HAUS6	Homo sapiens	Q7Z4H7	SLS	25173975
Intra	HAUS8	Q9BT25	q9y649_human	Homo sapiens	Q9Y649	Validated Y2H	32814053
Intra	HAUS8	Q9BT25	q9y649_human	Homo sapiens	Q9Y649	Y2H Array	32814053
Intra	HAUS8	Q9BT25	q9y649_human	Homo sapiens	Q9Y649	Y2H Pooling	32814053
Intra	HAUS8	Q9BT25	FGFR3	Homo sapiens	P22607	Y2H Array	32814053
Intra	HAUS8	Q9BT25	FGFR3	Homo sapiens	P22607	Validated Y2H	32814053
Intra	HAUS8	Q9BT25	FGFR3	Homo sapiens	P22607	Y2H Pooling	32814053
Intra	HAUS8	Q9BT25	HRAS	Homo sapiens	P01112	Y2H Pooling	32814053
Intra	HAUS8	Q9BT25	HRAS	Homo sapiens	P01112	Validated Y2H	32814053
Intra	HAUS8	Q9BT25	HRAS	Homo sapiens	P01112	Y2H Array	32814053
Intra	HAUS8	Q9BT25	NME7	Homo sapiens	Q9Y5B8	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Phosphoglycerate Dehydrogenase Deficiency	Phgdh Deficiency 3-Phosphoglycerate Dehydrogenase Deficiency PHGDHD 3-Pgdh Deficiency 3-Phosphoglycerate Dehydrogenase Deficiency, Infantile/Juvenile Form Phgdh Deficiency, Infantile/Juvenile Form Deficiency, Phosphoglycerate Dehydrogenase

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06020	HAUS8 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	HAUS8	VGNC	VGNC:73259
Bos taurus	HAUS8	VGNC	VGNC:29763
Canis familiaris	HAUS8	VGNC	VGNC:41608
Felis catus	HAUS8	VGNC	VGNC:62760
Mus musculus	HAUS8	MGD	MGI:1923728
Rattus norvegicus	HAUS8	RGD	RGD:1311565
Others	HAUS8	NCBI