CIAO2B - cytosolic iron-sulfur assembly component 2B Gene
Also Known as CIA2B; MIP18; FAM96B; CGI-128
Species: Homo sapiens
Gene Type: protein coding
Gene ID: 51647
Summary
Involved in chromosome segregation and protein maturation. Located in cytosol; nucleoplasm; and spindle. Part of MMXD complex and cytosolic [4Fe-4S] assembly targeting complex. [provided by Alliance of Genome Resources, Jul 2025]
Ubiquitous expression in kidney (RPKM 31.6), heart (RPKM 26.9) and 25 other tissues.
CIAO2B Products (1)
| mRNA | Protein | Name |
|---|---|---|
| NM_016062.4 | NP_057146.1 | cytosolic iron-sulfur assembly component 2B |
| Molecular Function GO Annotation | Evidence | References | Source |
|---|---|---|---|
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
16189514 | GOA |
| Biological Process GO Annotation | Evidence | References | Source |
|---|---|---|---|
| involved in chromosome segregation |
IMP
IMP: Inferred from mutant phenotype
|
20797633 | GOA |
| involved in iron-sulfur cluster assembly |
IMP
IMP: Inferred from mutant phenotype
|
23891004 | GOA |
| involved in protein maturation by iron-sulfur cluster transfer |
IMP
IMP: Inferred from mutant phenotype
|
23891004 | GOA |
| Cellular Component GO Annotation | Evidence | References | Source |
|---|---|---|---|
| part of MMXD complex |
IDA
IDA: Inferred from direct assay
|
20797633 | GOA |
| located in cytoplasm |
IDA
IDA: Inferred from direct assay
|
20797633 | GOA |
| part of cytosolic [4Fe-4S] assembly targeting complex |
IDA
IDA: Inferred from direct assay
|
22678361 | GOA |
| located in nucleus |
IDA
IDA: Inferred from direct assay
|
20797633 | GOA |
| located in spindle |
IDA
IDA: Inferred from direct assay
|
20797633 | GOA |
EXP: Inferred from Experiment
IDA: Inferred from direct assay
IPI: Inferred from physical interaction
IMP: Inferred from mutant phenotype
IGI: Inferred from genetic interaction
IEP: Inferred from expression pattern
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CIAO2B Protein-protein interaction Information
|
Type
|
Protein Name | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | References |
|---|---|---|---|---|---|---|---|
|
Intra
|
CIAO2B | Q9Y3D0 | MMS19 | Homo sapiens | Q96T76 | 23585563 | |
|
Intra
|
CIAO2B | Q9Y3D0 | MMS19 | Homo sapiens | Q96T76 | 28178521 | |
|
Intra
|
CIAO2B | Q9Y3D0 | KIF1B | Homo sapiens | O60333-2 | 32814053 | |
|
Intra
|
CIAO2B | Q9Y3D0 | KIF1B | Homo sapiens | O60333-2 | 32814053 | |
|
Intra
|
CIAO2B | Q9Y3D0 | KIF1B | Homo sapiens | O60333-2 | 32814053 | |
|
Intra
|
CIAO2B | Q9Y3D0 | LAMP2 | Homo sapiens | P13473-2 | 32814053 | |
|
Intra
|
CIAO2B | Q9Y3D0 | LAMP2 | Homo sapiens | P13473-2 | 32814053 | |
|
Intra
|
CIAO2B | Q9Y3D0 | LAMP2 | Homo sapiens | P13473-2 | 32814053 | |
|
Intra
|
CIAO2B | Q9Y3D0 | q9y649_human | Homo sapiens | Q9Y649 | 32814053 | |
|
Intra
|
CIAO2B | Q9Y3D0 | q9y649_human | Homo sapiens | Q9Y649 | 32814053 | |
|
Intra
|
CIAO2B | Q9Y3D0 | q9y649_human | Homo sapiens | Q9Y649 | 32814053 | |
|
Intra
|
CIAO2B | Q9Y3D0 | FGFR3 | Homo sapiens | P22607 | 32814053 | |
|
Intra
|
CIAO2B | Q9Y3D0 | FGFR3 | Homo sapiens | P22607 | 32814053 | |
|
Intra
|
CIAO2B | Q9Y3D0 | FGFR3 | Homo sapiens | P22607 | 32814053 | |
|
Intra
|
CIAO2B | Q9Y3D0 | GSN | Homo sapiens | P06396 | 32814053 | |
|
Intra
|
CIAO2B | Q9Y3D0 | GSN | Homo sapiens | P06396 | 32814053 | |
|
Intra
|
CIAO2B | Q9Y3D0 | GSN | Homo sapiens | P06396 | 32814053 | |
|
Intra
|
CIAO2B | Q9Y3D0 | HSPB1 | Homo sapiens | P04792 | 32814053 | |
|
Intra
|
CIAO2B | Q9Y3D0 | HSPB1 | Homo sapiens | P04792 | 32814053 | |
|
Intra
|
CIAO2B | Q9Y3D0 | HSPB1 | Homo sapiens | P04792 | 32814053 | |
|
Intra
|
CIAO2B | Q9Y3D0 | VIM | Homo sapiens | P08670 | 32814053 | |
|
Intra
|
CIAO2B | Q9Y3D0 | VIM | Homo sapiens | P08670 | 32814053 | |
|
Intra
|
CIAO2B | Q9Y3D0 | VIM | Homo sapiens | P08670 | 32814053 | |
|
Intra
|
CIAO2B | Q9Y3D0 | RAB5A | Homo sapiens | P20339 | 32814053 | |
|
Intra
|
CIAO2B | Q9Y3D0 | RAB5A | Homo sapiens | P20339 | 32814053 | |
|
Intra
|
CIAO2B | Q9Y3D0 | RAB5A | Homo sapiens | P20339 | 32814053 | |
|
Intra
|
CIAO2B | Q9Y3D0 | ERCC2 | Homo sapiens | P18074 | 23585563 | |
|
Intra
|
CIAO2B | Q9Y3D0 | CCK | Homo sapiens | P06307 | 32814053 | |
|
Intra
|
CIAO2B | Q9Y3D0 | CCK | Homo sapiens | P06307 | 32814053 | |
|
Intra
|
CIAO2B | Q9Y3D0 | CCK | Homo sapiens | P06307 | 32814053 | |
|
Intra
|
CIAO2B | Q9Y3D0 | TTR | Homo sapiens | P02766 | 32814053 | |
|
Intra
|
CIAO2B | Q9Y3D0 | TTR | Homo sapiens | P02766 | 32814053 | |
|
Intra
|
CIAO2B | Q9Y3D0 | TTR | Homo sapiens | P02766 | 32814053 | |
|
Intra
|
CIAO2B | Q9Y3D0 | PECAM1 | Homo sapiens | P16284 | 32814053 | |
|
Intra
|
CIAO2B | Q9Y3D0 | PECAM1 | Homo sapiens | P16284 | 32814053 | |
|
Intra
|
CIAO2B | Q9Y3D0 | PECAM1 | Homo sapiens | P16284 | 32814053 | |
|
Intra
|
CIAO2B | Q9Y3D0 | WFS1 | Homo sapiens | O76024 | 32814053 | |
|
Intra
|
CIAO2B | Q9Y3D0 | WFS1 | Homo sapiens | O76024 | 32814053 | |
|
Intra
|
CIAO2B | Q9Y3D0 | WFS1 | Homo sapiens | O76024 | 32814053 | |
|
Intra
|
CIAO2B | Q9Y3D0 | CIAO1 | Homo sapiens | O76071 | 32296183 | |
|
Intra
|
CIAO2B | Q9Y3D0 | CIAO1 | Homo sapiens | O76071 | 23585563 | |
|
Intra
|
CIAO2B | Q9Y3D0 | CIAO1 | Homo sapiens | O76071 | 23585563 | |
|
Intra
|
CIAO2B | Q9Y3D0 | CIAO1 | Homo sapiens | O76071 | 25416956 | |
|
Intra
|
CIAO2B | Q9Y3D0 | CIAO1 | Homo sapiens | O76071 | 25416956 | |
|
Intra
|
CIAO2B | Q9Y3D0 | CIAO1 | Homo sapiens | O76071 | 21516116 | |
|
Intra
|
CIAO2B | Q9Y3D0 | CIAO1 | Homo sapiens | O76071 | 28178521 | |
|
Intra
|
CIAO2B | Q9Y3D0 | CIAO1 | Homo sapiens | O76071 | 32296183 | |
|
Intra
|
CIAO2B | Q9Y3D0 | PRPS1 | Homo sapiens | P60891 | 32814053 | |
|
Intra
|
CIAO2B | Q9Y3D0 | PRPS1 | Homo sapiens | P60891 | 32814053 | |
|
Intra
|
CIAO2B | Q9Y3D0 | PRPS1 | Homo sapiens | P60891 | 32814053 |
Cross: Cross-species interaction
Intra: Intraspecies interaction